MED6 [The Human Chemical-Genetic Interaction Map Project]

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======= MED6 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MED6
  * **<color #00a2e8>Official Name</color>**: mediator complex subunit 6
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10001|10001]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O75586|O75586]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MED6&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MED6|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602984|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Med6|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|core mediator complex|
|RNA polymerase II preinitiation complex assembly|
|transcription preinitiation complex assembly|
|mediator complex|
|transcription initiation from RNA polymerase II promoter|
|protein-DNA complex assembly|
|DNA-templated transcription, initiation|
|protein-DNA complex subunit organization|
|transcription coactivator activity|
|transcription factor binding|
|transcription by RNA polymerase II|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|RNA biosynthetic process|
|cellular protein-containing complex assembly|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|positive regulation of transcription by RNA polymerase II|
|organic cyclic compound biosynthetic process|
|positive regulation of transcription, DNA-templated|
|protein-containing complex assembly|
|cellular nitrogen compound biosynthetic process|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|positive regulation of RNA metabolic process|
|macromolecule biosynthetic process|
|protein-containing complex subunit organization|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|membrane|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp191|Hypoxia 5%O2 R04 exp191]]|-1.79|
|[[:results:exp462|Cadmium 60μM R08 exp462]]|-1.75|
|[[:results:exp326|CCT251545 20μM R07 exp326]]|1.73|
|[[:results:exp303|39°C R06 exp303]]|1.83|
|[[:results:exp487|Hinokiflavone 12μM R08 exp487]]|2.37|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 571/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|24/28|
|blood|27/28|
|bone|23/25|
|breast|23/33|
|central nervous system|45/56|
|cervix|3/4|
|colorectal|16/17|
|esophagus|8/13|
|fibroblast|1/1|
|gastric|9/15|
|kidney|19/21|
|liver|14/20|
|lung|55/75|
|lymphocyte|10/14|
|ovary|18/26|
|pancreas|18/24|
|peripheral nervous system|14/16|
|plasma cell|14/15|
|prostate|1/1|
|skin|22/24|
|soft tissue|5/7|
|thyroid|2/2|
|upper aerodigestive|13/22|
|urinary tract|23/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2899
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.11 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MED6 Expression in NALM6 Cells: 5.11'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>