MEF2C [The Human Chemical-Genetic Interaction Map Project]

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======= MEF2C =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MEF2C
  * **<color #00a2e8>Official Name</color>**: myocyte enhancer factor 2C
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4208|4208]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q06413|Q06413]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MEF2C&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MEF2C|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600662|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This locus encodes a member of the MADS box transcription enhancer factor 2 (MEF2) family of proteins, which play a role in myogenesis. The encoded protein, MEF2 polypeptide C, has both trans-activating and DNA binding activities. This protein may play a role in maintaining the differentiated state of muscle cells. Mutations and deletions at this locus have been associated with severe cognitive disability, stereotypic movements, epilepsy, and cerebral malformation. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle- specific genes. Controls cardiac morphogenesis and myogenesis, and is also involved in vascular development. Plays an essential role in hippocampal-dependent learning and memory by suppressing the number of excitatory synapses and thus regulating basal and evoked synaptic transmission. Crucial for normal neuronal development, distribution, and electrical activity in the neocortex. Necessary for proper development of megakaryocytes and platelets and for bone marrow B-lymphopoiesis. Required for B-cell survival and proliferation in response to BCR stimulation, efficient IgG1 antibody responses to T-cell-dependent antigens and for normal induction of germinal center B-cells. May also be involved in neurogenesis and in the development of cortical architecture (By similarity). Isoform 3 and isoform 4, which lack the repressor domain, are more active than isoform 1 and isoform 2. {ECO:0000250|UniProtKB:Q8CFN5, ECO:0000269|PubMed:11904443, ECO:0000269|PubMed:15340086, ECO:0000269|PubMed:15831463, ECO:0000269|PubMed:15834131, ECO:0000269|PubMed:9069290, ECO:0000269|PubMed:9384584}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|HJURP C|
|SRF-TF|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|sinoatrial valve morphogenesis|
|primary heart field specification|
|sinoatrial valve development|
|nephron tubule epithelial cell differentiation|
|muscle cell fate determination|
|cellular response to trichostatin A|
|positive regulation of macrophage apoptotic process|
|response to trichostatin A|
|regulation of synaptic activity|
|epithelial cell proliferation involved in renal tubule morphogenesis|
|negative regulation of vascular endothelial cell proliferation|
|positive regulation of alkaline phosphatase activity|
|positive regulation of skeletal muscle cell differentiation|
|negative regulation of vascular associated smooth muscle cell migration|
|positive regulation of fear response|
|positive regulation of cell proliferation in bone marrow|
|positive regulation of behavioral fear response|
|regulation of sarcomere organization|
|regulation of cell proliferation in bone marrow|
|positive regulation of myeloid cell apoptotic process|
|glomerulus morphogenesis|
|germinal center formation|
|secondary heart field specification|
|AT DNA binding|
|regulation of germinal center formation|
|regulation of behavioral fear response|
|cellular response to parathyroid hormone stimulus|
|regulation of fear response|
|regulation of alkaline phosphatase activity|
|sarcoplasm|
|heart field specification|
|embryonic viscerocranium morphogenesis|
|regulation of macrophage apoptotic process|
|cardiac ventricle formation|
|positive regulation of protein homodimerization activity|
|cardiac chamber formation|
|response to parathyroid hormone|
|heart formation|
|cardiac muscle hypertrophy in response to stress|
|cardiac muscle adaptation|
|muscle hypertrophy in response to stress|
|specification of animal organ identity|
|muscle cell fate commitment|
|ventricular cardiac muscle cell differentiation|
|HMG box domain binding|
|mononuclear cell differentiation|
|monocyte differentiation|
|cellular response to fluid shear stress|
|negative regulation of vascular smooth muscle cell proliferation|
|positive regulation of cardiac muscle cell differentiation|
|regulation of vascular endothelial cell proliferation|
|platelet formation|
|regulation of skeletal muscle cell differentiation|
|platelet morphogenesis|
|melanocyte differentiation|
|regulation of protein homodimerization activity|
|regulation of vascular associated smooth muscle cell migration|
|positive regulation of myoblast differentiation|
|negative regulation of smooth muscle cell migration|
|positive regulation of cardiac muscle cell proliferation|
|regulation of AMPA receptor activity|
|positive regulation of skeletal muscle tissue development|
|B cell homeostasis|
|striated muscle adaptation|
|endochondral ossification|
|positive regulation of cardiocyte differentiation|
|positive regulation of behavior|
|replacement ossification|
|positive regulation of leukocyte apoptotic process|
|cardiac muscle hypertrophy|
|cartilage morphogenesis|
|regulation of myeloid cell apoptotic process|
|striated muscle hypertrophy|
|epithelial cell differentiation involved in kidney development|
|pigment cell differentiation|
|muscle adaptation|
|muscle hypertrophy|
|blood vessel remodeling|
|negative regulation of blood vessel endothelial cell migration|
|smooth muscle cell differentiation|
|activating transcription factor binding|
|positive regulation of cardiac muscle tissue growth|
|response to fluid shear stress|
|positive regulation of phosphatase activity|
|animal organ formation|
|regulation of cardiac muscle cell differentiation|
|regulation of NMDA receptor activity|
|negative regulation of endothelial cell proliferation|
|positive regulation of heart growth|
|positive regulation of bone mineralization|
|cell fate determination|
|developmental pigmentation|
|regulation of cardiac muscle cell proliferation|
|cell differentiation involved in kidney development|
|positive regulation of B cell proliferation|
|B cell proliferation|
|positive regulation of cardiac muscle tissue development|
|negative regulation of smooth muscle cell proliferation|
|embryonic cranial skeleton morphogenesis|
|positive regulation of biomineral tissue development|
|positive regulation of biomineralization|
|positive regulation of organ growth|
|negative regulation of endothelial cell migration|
|regulation of skeletal muscle tissue development|
|regulation of cardiocyte differentiation|
|skeletal muscle cell differentiation|
|regulation of vascular smooth muscle cell proliferation|
|glomerulus development|
|heart valve morphogenesis|
|lymphocyte homeostasis|
|regulation of myoblast differentiation|
|regulation of megakaryocyte differentiation|
|myotube differentiation|
|positive regulation of dephosphorylation|
|positive regulation of osteoblast differentiation|
|positive regulation of striated muscle cell differentiation|
|regulation of cardiac muscle tissue growth|
|regulation of smooth muscle cell migration|
|heart looping|
|heart valve development|
|regulation of B cell proliferation|
|excitatory postsynaptic potential|
|regulation of heart growth|
|regulation of glutamate receptor signaling pathway|
|cranial skeletal system development|
|determination of heart left/right asymmetry|
|negative regulation of epithelial cell migration|
|embryonic heart tube morphogenesis|
|chemical synaptic transmission, postsynaptic|
|renal tubule morphogenesis|
|regulation of synaptic transmission, glutamatergic|
|positive regulation of muscle organ development|
|leukocyte homeostasis|
|positive regulation of striated muscle tissue development|
|positive regulation of muscle tissue development|
|regulation of behavior|
|endochondral bone morphogenesis|
|regulation of dendritic spine development|
|outflow tract morphogenesis|
|cardiac ventricle morphogenesis|
|negative regulation of ossification|
|regulation of neurotransmitter receptor activity|
|regulation of bone mineralization|
|embryonic heart tube development|
|nephron tubule development|
|regulation of cardiac muscle tissue development|
|renal tubule development|
|chondrocyte differentiation|
|regulation of leukocyte apoptotic process|
|lymphocyte proliferation|
|cellular response to calcium ion|
|postsynapse|
|positive regulation of ossification|
|mononuclear cell proliferation|
|positive regulation of muscle cell differentiation|
|epithelial cell proliferation|
|cardiac muscle cell differentiation|
|neural crest cell differentiation|
|regulation of actomyosin structure organization|
|regulation of blood vessel endothelial cell migration|
|roof of mouth development|
|pigmentation|
|regulation of biomineral tissue development|
|regulation of biomineralization|
|positive regulation of protein binding|
|embryonic skeletal system morphogenesis|
|regulation of organ growth|
|nephron epithelium development|
|leukocyte proliferation|
|RNA polymerase II distal enhancer sequence-specific DNA binding|
|regulation of postsynaptic membrane potential|
|tissue remodeling|
|regulation of striated muscle cell differentiation|
|regulation of neurotransmitter secretion|
|regulation of synapse assembly|
|myeloid leukocyte differentiation|
|histone deacetylase binding|
|regulation of osteoblast differentiation|
|bone morphogenesis|
|cardiocyte differentiation|
|determination of left/right symmetry|
|cellular response to antibiotic|
|neuron migration|
|skeletal muscle tissue development|
|determination of bilateral symmetry|
|negative regulation of epithelial cell proliferation|
|specification of symmetry|
|nephron development|
|osteoblast differentiation|
|embryonic skeletal system development|
|cardiac chamber morphogenesis|
|cardiac ventricle development|
|B cell receptor signaling pathway|
|regulation of endothelial cell proliferation|
|kidney epithelium development|
|positive regulation of lymphocyte proliferation|
|positive regulation of mononuclear cell proliferation|
|regulation of striated muscle tissue development|
|skeletal muscle organ development|
|regulation of smooth muscle cell proliferation|
|regulation of muscle tissue development|
|regulation of muscle organ development|
|positive regulation of leukocyte proliferation|
|regulation of neurotransmitter transport|
|regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|negative regulation of neuron apoptotic process|
|regulation of dendrite development|
|response to calcium ion|
|regulation of muscle cell differentiation|
|B cell activation|
|cellular response to transforming growth factor beta stimulus|
|mesenchymal cell differentiation|
|stem cell differentiation|
|regulation of endothelial cell migration|
|regulation of adaptive immune response|
|response to transforming growth factor beta|
|cardiac muscle tissue development|
|positive regulation of B cell activation|
|cardiac chamber development|
|positive regulation of developmental growth|
|regulation of cation channel activity|
|cartilage development|
|regulation of signaling receptor activity|
|regulation of phosphatase activity|
|positive regulation of binding|
|cellular response to lipopolysaccharide|
|regulation of synaptic plasticity|
|regulation of ossification|
|cellular response to metal ion|
|cellular response to molecule of bacterial origin|
|bone development|
|homeostasis of number of cells|
|striated muscle cell differentiation|
|negative regulation of neuron death|
|regulation of neuron apoptotic process|
|regulation of B cell activation|
|regulation of lymphocyte proliferation|
|regulation of mononuclear cell proliferation|
|regulation of dephosphorylation|
|cellular response to biotic stimulus|
|regulation of synapse organization|
|transcription regulatory region DNA binding|
|regulation of protein binding|
|myeloid cell differentiation|
|regulation of organelle assembly|
|regulation of epithelial cell migration|
|cellular response to inorganic substance|
|mesenchyme development|
|regulation of leukocyte proliferation|
|connective tissue development|
|regulation of myeloid cell differentiation|
|regulation of synapse structure or activity|
|nuclear chromatin|
|skeletal system morphogenesis|
|muscle cell differentiation|
|cell fate commitment|
|heart morphogenesis|
|regulation of ion transmembrane transporter activity|
|negative regulation of cell migration|
|positive regulation of growth|
|learning or memory|
|ossification|
|regulation of transmembrane transporter activity|
|kidney development|
|negative regulation of cell motility|
|regulation of transporter activity|
|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|striated muscle tissue development|
|renal system development|
|embryonic organ morphogenesis|
|antigen receptor-mediated signaling pathway|
|muscle organ development|
|muscle tissue development|
|cognition|
|muscle system process|
|response to antibiotic|
|epithelial tube morphogenesis|
|negative regulation of cellular component movement|
|regulation of neuron death|
|RNA polymerase II regulatory region sequence-specific DNA binding|
|response to lipopolysaccharide|
|urogenital system development|
|negative regulation of locomotion|
|response to molecule of bacterial origin|
|regulation of developmental growth|
|leukocyte differentiation|
|regionalization|
|regulation of cation transmembrane transport|
|regulation of epithelial cell proliferation|
|regulation of actin cytoskeleton organization|
|humoral immune response|
|regulation of supramolecular fiber organization|
|regulation of neurotransmitter levels|
|positive regulation of lymphocyte activation|
|positive regulation of neuron differentiation|
|response to metal ion|
|MAPK cascade|
|regulation of binding|
|lymphocyte activation|
|regulation of actin filament-based process|
|signal transduction by protein phosphorylation|
|chromatin binding|
|nuclear speck|
|cellular response to drug|
|positive regulation of leukocyte activation|
|positive regulation of cell activation|
|anterograde trans-synaptic signaling|
|chemical synaptic transmission|
|cell surface receptor signaling pathway involved in cell-cell signaling|
|regulation of membrane potential|
|cell morphogenesis involved in neuron differentiation|
|morphogenesis of an epithelium|
|embryonic organ development|
|pattern specification process|
|trans-synaptic signaling|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|DNA-binding transcription activator activity, RNA polymerase II-specific|
|immune response-activating cell surface receptor signaling pathway|
|regulation of hemopoiesis|
|synaptic signaling|
|positive regulation of neurogenesis|
|positive regulation of defense response|
|muscle structure development|
|regulation of ion transmembrane transport|
|immune response-regulating cell surface receptor signaling pathway|
|blood vessel development|
|protein heterodimerization activity|
|skeletal system development|
|regulation of neuron projection development|
|cellular response to growth factor stimulus|
|RNA polymerase II proximal promoter sequence-specific DNA binding|
|vasculature development|
|regulation of lymphocyte activation|
|cardiovascular system development|
|cellular response to lipid|
|heart development|
|response to growth factor|
|response to inorganic substance|
|positive regulation of nervous system development|
|regulation of cytoskeleton organization|
|cellular response to organic cyclic compound|
|positive regulation of cell development|
|cell population proliferation|
|cell morphogenesis involved in differentiation|
|hemopoiesis|
|immune response-activating signal transduction|
|regulation of transmembrane transport|
|tissue morphogenesis|
|embryonic morphogenesis|
|behavior|
|immune response-regulating signaling pathway|
|protein-containing complex|
|cellular response to organonitrogen compound|
|regulation of leukocyte activation|
|cellular response to hormone stimulus|
|hematopoietic or lymphoid organ development|
|adaptive immune response|
|activation of immune response|
|chordate embryonic development|
|regulation of cell activation|
|positive regulation of apoptotic process|
|immune system development|
|positive regulation of programmed cell death|
|embryo development ending in birth or egg hatching|
|tube morphogenesis|
|regulation of neuron differentiation|
|cellular response to nitrogen compound|
|regulation of growth|
|DNA-binding transcription factor activity|
|negative regulation of cell population proliferation|
|epithelial cell differentiation|
|intracellular membrane-bounded organelle|
|response to bacterium|
|regulation of plasma membrane bounded cell projection organization|
|positive regulation of cell death|
|regulation of ion transport|
|regulation of cell projection organization|
|cell morphogenesis|
|regulation of secretion by cell|
|regulation of defense response|
|positive regulation of hydrolase activity|
|regulation of secretion|
|neuron development|
|regulation of neurogenesis|
|cellular component morphogenesis|
|tube development|
|regulation of cell migration|
|response to lipid|
|negative regulation of transcription by RNA polymerase II|
|positive regulation of immune response|
|circulatory system development|
|negative regulation of apoptotic process|
|anatomical structure formation involved in morphogenesis|
|negative regulation of programmed cell death|
|response to hormone|
|regulation of cell motility|
|positive regulation of cell population proliferation|
|regulation of cellular localization|
|response to organic cyclic compound|
|apoptotic process|
|regulation of nervous system development|
|leukocyte activation|
|regulation of cell development|
|animal organ morphogenesis|
|regulation of cellular component biogenesis|
|cell migration|
|positive regulation of cell differentiation|
|protein phosphorylation|
|embryo development|
|regulation of locomotion|
|negative regulation of cell death|
|regulation of cellular component movement|
|response to organonitrogen compound|
|neuron differentiation|
|response to drug|
|programmed cell death|
|cellular response to oxygen-containing compound|
|regulation of anatomical structure morphogenesis|
|cell activation|
|localization of cell|
|cell motility|
|response to nitrogen compound|
|cell death|
|epithelium development|
|cell-cell signaling|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|positive regulation of immune system process|
|regulation of immune response|
|negative regulation of transcription, DNA-templated|
|negative regulation of multicellular organismal process|
|positive regulation of transcription by RNA polymerase II|
|cellular response to endogenous stimulus|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|regulation of hydrolase activity|
|phosphorylation|
|regulation of organelle organization|
|response to other organism|
|response to external biotic stimulus|
|locomotion|
|response to biotic stimulus|
|negative regulation of RNA metabolic process|
|positive regulation of developmental process|
|nervous system process|
|negative regulation of cellular macromolecule biosynthetic process|
|positive regulation of catalytic activity|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|response to endogenous stimulus|
|regulation of response to stress|
|negative regulation of cellular biosynthetic process|
|generation of neurons|
|regulation of apoptotic process|
|positive regulation of transcription, DNA-templated|
|negative regulation of biosynthetic process|
|movement of cell or subcellular component|
|response to oxygen-containing compound|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|regulation of programmed cell death|
|regulation of cell population proliferation|
|neurogenesis|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|homeostatic process|
|cell development|
|regulation of immune system process|
|regulation of cell death|
|intracellular signal transduction|
|cellular response to stress|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|tissue development|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|regulation of transport|
|immune response|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|system process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp245|UM0011500 5μM R05 exp245]]|-3.29|
|[[:results:exp497|Lead acetate 2000μM R08 exp497]]|-2.83|
|[[:results:exp30|Rapamycin 10μM R00 exp30]]|-2.63|
|[[:results:exp29|Rapamycin 1μM R00 exp29]]|-2.42|
|[[:results:exp159|Docetaxel 0.001 to 0.002μM on day4 R04 exp159]]|-2.17|
|[[:results:exp429|Rapamycin 0.001μM R08 exp429]]|-2.15|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|-2.11|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|-2.11|
|[[:results:exp391|Pomalidomide 20μM R07 exp391]]|-2.05|
|[[:results:exp89|Vemurafenib 6.6μM R02 exp89]]|-1.95|
|[[:results:exp37|Wortmannin 0.5μM R00 exp37]]|-1.95|
|[[:results:exp189|Temozolomide 200μM R04 exp189]]|-1.92|
|[[:results:exp280|Daidzin 10μM R06 exp280]]|-1.9|
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|-1.9|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|-1.77|
|[[:results:exp498|Lead acetate 2000μM R08 exp498 no dilution day6]]|-1.77|
|[[:results:exp530|Thioridazine 5μM R08 exp530]]|-1.77|
|[[:results:exp333|All-trans-Retinoic-Acid 8μM R07 exp333]]|-1.71|
|[[:results:exp107|UMK57 0.6μM R03 exp107]]|1.71|
|[[:results:exp59|UMK57 1μM R01 exp59]]|1.72|
|[[:results:exp135|MS023 7μM R03 exp135]]|1.73|
|[[:results:exp228|Demecolcine 0.03μM R05 exp228]]|1.79|
|[[:results:exp98|BI-6727 0.04μM R03 exp98]]|1.88|
|[[:results:exp95|BI-2536 0.0042μM R03 exp95]]|1.95|
|[[:results:exp97|BI-6727 0.0125μM R03 exp97]]|2.05|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|2.51|
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|2.78|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:z:zfx|ZFX]]|0.528|
|[[:human genes:m:maml1|MAML1]]|0.483|
|[[:human genes:i:irf2bp2|IRF2BP2]]|0.481|
|[[:human genes:x:xpo6|XPO6]]|0.48|
|[[:human genes:a:asxl2|ASXL2]]|0.469|
|[[:human genes:z:znf319|ZNF319]]|0.448|
|[[:human genes:f:fli1|FLI1]]|0.446|
|[[:human genes:c:ctdspl2|CTDSPL2]]|0.441|
|[[:human genes:i:id3|ID3]]|0.438|
|[[:human genes:a:asb7|ASB7]]|0.438|
|[[:human genes:s:scaf8|SCAF8]]|0.418|
|[[:human genes:t:trim33|TRIM33]]|0.416|
|[[:human genes:z:zmym2|ZMYM2]]|0.411|
|[[:human genes:e:erg|ERG]]|0.409|
|[[:human genes:b:brpf1|BRPF1]]|0.409|
|[[:human genes:m:med23|MED23]]|0.408|
|[[:human genes:c:cbfb|CBFB]]|0.406|
|[[:human genes:l:ldb1|LDB1]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 12/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|3/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|7/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5192
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.15 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MEF2C Expression in NALM6 Cells: 7.15'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>