MEOX2 [The Human Chemical-Genetic Interaction Map Project]

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======= MEOX2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MEOX2
  * **<color #00a2e8>Official Name</color>**: mesenchyme homeobox 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4223|4223]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P50222|P50222]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MEOX2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MEOX2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600535|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of a subfamily of non-clustered, diverged, antennapedia-like homeobox-containing genes. The encoded protein may play a role in the regulation of vertebrate limb myogenesis. Mutations in the related mouse protein may be associated with craniofacial and/or skeletal abnormalities, in addition to neurovascular dysfunction observed in Alzheimer's disease. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Mesodermal transcription factor that plays a key role in somitogenesis and is required for sclerotome development (By similarity). Activates expression of CDKN1A and CDKN2A in endothelial cells, acting as a regulator of vascular cell proliferation. While it activates CDKN1A in a DNA-dependent manner, it activates CDKN2A in a DNA-independent manner (PubMed:22206000). May have a regulatory role when quiescent vascular smooth muscle cells reenter the cell cycle. {ECO:0000250|UniProtKB:P32443, ECO:0000269|PubMed:22206000}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Homeobox|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|somite specification|
|negative regulation of cell migration involved in sprouting angiogenesis|
|segment specification|
|negative regulation of sprouting angiogenesis|
|negative regulation of blood vessel endothelial cell migration|
|regulation of cell migration involved in sprouting angiogenesis|
|negative regulation of endothelial cell migration|
|embryonic pattern specification|
|somitogenesis|
|negative regulation of epithelial cell migration|
|regulation of sprouting angiogenesis|
|somite development|
|regulation of blood vessel endothelial cell migration|
|roof of mouth development|
|segmentation|
|RNA polymerase II distal enhancer sequence-specific DNA binding|
|negative regulation of angiogenesis|
|negative regulation of blood vessel morphogenesis|
|negative regulation of vasculature development|
|skeletal muscle tissue development|
|skeletal muscle organ development|
|regulation of endothelial cell migration|
|appendage development|
|limb development|
|anterior/posterior pattern specification|
|regulation of epithelial cell migration|
|negative regulation of cell migration|
|negative regulation of cell motility|
|striated muscle tissue development|
|regulation of angiogenesis|
|muscle organ development|
|muscle tissue development|
|negative regulation of cellular component movement|
|angiogenesis|
|regulation of vasculature development|
|negative regulation of locomotion|
|regionalization|
|blood circulation|
|circulatory system process|
|nuclear speck|
|blood vessel morphogenesis|
|sequence-specific DNA binding|
|pattern specification process|
|DNA-binding transcription activator activity, RNA polymerase II-specific|
|muscle structure development|
|blood vessel development|
|RNA polymerase II proximal promoter sequence-specific DNA binding|
|vasculature development|
|cardiovascular system development|
|chordate embryonic development|
|embryo development ending in birth or egg hatching|
|tube morphogenesis|
|DNA-binding transcription factor activity|
|tube development|
|regulation of cell migration|
|circulatory system development|
|anatomical structure formation involved in morphogenesis|
|regulation of cell motility|
|negative regulation of developmental process|
|embryo development|
|regulation of locomotion|
|regulation of cellular component movement|
|regulation of anatomical structure morphogenesis|
|epithelium development|
|negative regulation of multicellular organismal process|
|positive regulation of transcription by RNA polymerase II|
|positive regulation of transcription, DNA-templated|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|positive regulation of RNA metabolic process|
|tissue development|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|system process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp222|Betulinic acid 10 to 15μM on day4 R05 exp222]]|-2|
|[[:results:exp277|Curcumin 6.5μM R06 exp277]]|-1.76|
|[[:results:exp244|SB743921 0.001μM R05 exp244]]|2.02|
|[[:results:exp94|Nocodazole 0.1μM R03 exp94]]|2.04|
|[[:results:exp33|Rotenone 2μM R00 exp33]]|2.16|
|[[:results:exp24|Nocodazole 0.2μM R00 exp24]]|2.33|
|[[:results:exp208|Vinblastine 0.015μM R05 exp208]]|2.52|
|[[:results:exp256|HMS-I1 10μM R06 exp256]]|3.09|
|[[:results:exp93|DABN racemic mixture R03 exp93]]|3.32|
|[[:results:exp111|R-DABN 8μM R03 exp111]]|3.75|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 16197
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -4.27 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MEOX2 Expression in NALM6 Cells: -4.27'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>