MFAP1 [The Human Chemical-Genetic Interaction Map Project]

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======= MFAP1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MFAP1
  * **<color #00a2e8>Official Name</color>**: microfibril associated protein 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4236|4236]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P55081|P55081]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MFAP1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MFAP1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600215|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  May be required for pre-mRNA splicing. {ECO:0000250|UniProtKB:Q9W062}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|MFAP1 C|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|microfibril|
|U2-type precatalytic spliceosome|
|RNA splicing, via transesterification reactions with bulged adenosine as nucleophile|
|mRNA splicing, via spliceosome|
|RNA splicing, via transesterification reactions|
|RNA splicing|
|mRNA processing|
|mRNA metabolic process|
|RNA processing|
|RNA binding|
|RNA metabolic process|
|extracellular region|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp93|DABN racemic mixture R03 exp93]]|-2.08|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|-2|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|-1.81|
|[[:results:exp342|Calcium Ionophore 0.4μM R07 exp342]]|1.7|
|[[:results:exp242|Radicicol 0.16μM R05 exp242]]|1.7|
|[[:results:exp209|Deguelin 0.15μM R05 exp209]]|1.72|
|[[:results:exp230|Epigallocatechin gallate 20μM R05 exp230]]|1.8|
|[[:results:exp152|SGC2043 10μM R03 exp152]]|1.88|
|[[:results:exp146|Quinacrine 2.5μM R03 exp146]]|1.91|
|[[:results:exp101|Nicotinamide 1000μM R03 exp101]]|1.95|
|[[:results:exp51|Nifuroxazide 1μM R01 exp51]]|1.96|
|[[:results:exp455|Benzoate 10000μM R08 exp455]]|2.16|
|[[:results:exp458|Bisphenol S 100μM R08 exp458]]|2.43|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hgc6.3|HGC6.3]]|0.507|
|[[:human genes:p:polr2j3|POLR2J3]]|0.483|
|[[:human genes:r:rpl35|RPL35]]|0.411|
|[[:human genes:r:rps12|RPS12]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 620/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|19/28|
|blood|22/28|
|bone|26/26|
|breast|25/33|
|central nervous system|49/56|
|cervix|2/4|
|colorectal|15/17|
|esophagus|12/13|
|fibroblast|1/1|
|gastric|16/16|
|kidney|15/21|
|liver|18/20|
|lung|64/75|
|lymphocyte|9/16|
|ovary|25/26|
|pancreas|20/24|
|peripheral nervous system|13/16|
|plasma cell|14/15|
|prostate|1/1|
|skin|20/24|
|soft tissue|8/9|
|thyroid|2/2|
|upper aerodigestive|14/22|
|urinary tract|24/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1762
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.7 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MFAP1 Expression in NALM6 Cells: 5.7'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>