MFF [The Human Chemical-Genetic Interaction Map Project]

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======= MFF =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MFF
  * **<color #00a2e8>Official Name</color>**: mitochondrial fission factor
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=56947|56947]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9GZY8|Q9GZY8]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MFF&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MFF|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/614785|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This is a nuclear gene encoding a protein that functions in mitochondrial and peroxisomal fission. The encoded protein recruits dynamin-1-like protein (DNM1L) to mitochondria. There are multiple pseudogenes for this gene on chromosomes 1, 5, and X. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2013]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Plays a role in mitochondrial and peroxisomal fission. Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface. May be involved in regulation of synaptic vesicle membrane dynamics by recruitment of DNM1L to clathrin-containing vesicles. {ECO:0000269|PubMed:18353969, ECO:0000269|PubMed:23530241}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DUF800|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of peroxisome organization|
|peroxisome fission|
|integral component of mitochondrial membrane|
|mitochondrial fragmentation involved in apoptotic process|
|positive regulation of mitochondrial fission|
|mitochondrial fusion|
|mitochondrial fission|
|mitochondrion morphogenesis|
|release of cytochrome c from mitochondria|
|regulation of mitochondrial fission|
|positive regulation of release of cytochrome c from mitochondria|
|positive regulation of protein targeting to membrane|
|regulation of protein targeting to membrane|
|regulation of release of cytochrome c from mitochondria|
|protein targeting to mitochondrion|
|apoptotic mitochondrial changes|
|establishment of protein localization to mitochondrion|
|protein localization to mitochondrion|
|peroxisome organization|
|regulation of protein targeting|
|organelle fusion|
|peroxisome|
|positive regulation of mitochondrion organization|
|synaptic vesicle|
|positive regulation of protein localization to membrane|
|positive regulation of intracellular protein transport|
|mitochondrial outer membrane|
|positive regulation of apoptotic signaling pathway|
|regulation of mitochondrion organization|
|regulation of protein localization to membrane|
|positive regulation of intracellular transport|
|mitochondrial transport|
|regulation of intracellular protein transport|
|apoptotic signaling pathway|
|organelle fission|
|positive regulation of cellular protein localization|
|protein homooligomerization|
|regulation of intracellular transport|
|protein targeting|
|regulation of apoptotic signaling pathway|
|positive regulation of protein transport|
|establishment of protein localization to organelle|
|mitochondrion organization|
|positive regulation of establishment of protein localization|
|cell part morphogenesis|
|protein complex oligomerization|
|regulation of cellular protein localization|
|cell junction|
|positive regulation of organelle organization|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|positive regulation of cell death|
|regulation of protein transport|
|protein localization to organelle|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|cellular component morphogenesis|
|protein homodimerization activity|
|regulation of cellular localization|
|apoptotic process|
|positive regulation of transport|
|intracellular protein transport|
|regulation of protein localization|
|programmed cell death|
|regulation of anatomical structure morphogenesis|
|cell death|
|positive regulation of cellular component organization|
|mitochondrion|
|regulation of organelle organization|
|positive regulation of developmental process|
|protein transport|
|intracellular transport|
|peptide transport|
|regulation of apoptotic process|
|protein-containing complex assembly|
|regulation of programmed cell death|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|positive regulation of signal transduction|
|regulation of cell death|
|positive regulation of cell communication|
|positive regulation of signaling|
|establishment of localization in cell|
|nitrogen compound transport|
|protein-containing complex subunit organization|
|regulation of transport|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17357
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.56 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MFF Expression in NALM6 Cells: 5.56'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>