MICA [The Human Chemical-Genetic Interaction Map Project]

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======= MICA =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MICA
  * **<color #00a2e8>Official Name</color>**: MHC class I polypeptide-related sequence A
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=100507436|100507436]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q29983|Q29983]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MICA&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MICA|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600169|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes the highly polymorphic major histocompatability complex class I chain-related protein A. The protein product is expressed on the cell surface, although unlike canonical class I molecules it does not seem to associate with beta-2-microglobulin. It is a ligand for the NKG2-D type II integral membrane protein receptor. The protein functions as a stress-induced antigen that is broadly recognized by intestinal epithelial gamma delta T cells. Variations in this gene have been associated with susceptibility to psoriasis 1 and psoriatic arthritis, and the shedding of MICA-related antibodies and ligands is involved in the progression from monoclonal gammopathy of undetermined significance to multiple myeloma. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2014]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Seems to have no role in antigen presentation. Acts as a stress-induced self-antigen that is recognized by gamma delta T- cells. Ligand for the KLRK1/NKG2D receptor. Binding to KLRK1 leads to cell lysis. {ECO:0000269|PubMed:10426993, ECO:0000269|PubMed:11224526, ECO:0000269|PubMed:11491531, ECO:0000269|PubMed:11777960, ECO:0000269|PubMed:9497295}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|C1-set|
|MHC I|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|immune response to tumor cell|
|gamma-delta T cell activation|
|beta-2-microglobulin binding|
|negative regulation of natural killer cell activation|
|natural killer cell lectin-like receptor binding|
|response to tumor cell|
|susceptibility to natural killer cell mediated cytotoxicity|
|negative regulation of natural killer cell mediated cytotoxicity|
|negative regulation of natural killer cell mediated immunity|
|T cell mediated cytotoxicity|
|negative regulation of leukocyte mediated cytotoxicity|
|negative regulation of cell killing|
|cytolysis|
|natural killer cell mediated cytotoxicity|
|natural killer cell mediated immunity|
|positive regulation of natural killer cell mediated cytotoxicity|
|regulation of natural killer cell activation|
|positive regulation of natural killer cell mediated immunity|
|negative regulation of lymphocyte mediated immunity|
|leukocyte mediated cytotoxicity|
|T cell mediated immunity|
|regulation of natural killer cell mediated cytotoxicity|
|regulation of natural killer cell mediated immunity|
|negative regulation of leukocyte mediated immunity|
|positive regulation of leukocyte mediated cytotoxicity|
|negative regulation of innate immune response|
|natural killer cell activation|
|positive regulation of cell killing|
|regulation of leukocyte mediated cytotoxicity|
|cell killing|
|negative regulation of response to biotic stimulus|
|regulation of cell killing|
|positive regulation of lymphocyte mediated immunity|
|response to heat|
|negative regulation of immune effector process|
|positive regulation of leukocyte mediated immunity|
|negative regulation of lymphocyte activation|
|negative regulation of immune response|
|regulation of lymphocyte mediated immunity|
|negative regulation of leukocyte activation|
|response to temperature stimulus|
|defense response to virus|
|negative regulation of cell activation|
|regulation of leukocyte mediated immunity|
|negative regulation of defense response|
|negative regulation of multi-organism process|
|positive regulation of immune effector process|
|T cell activation|
|lymphocyte mediated immunity|
|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|response to virus|
|defense response to bacterium|
|positive regulation of innate immune response|
|positive regulation of response to biotic stimulus|
|negative regulation of response to external stimulus|
|lymphocyte activation|
|external side of plasma membrane|
|negative regulation of immune system process|
|regulation of innate immune response|
|regulation of immune effector process|
|positive regulation of defense response|
|positive regulation of multi-organism process|
|regulation of lymphocyte activation|
|regulation of response to biotic stimulus|
|positive regulation of response to external stimulus|
|regulation of leukocyte activation|
|adaptive immune response|
|cell surface|
|regulation of cell activation|
|response to bacterium|
|viral process|
|regulation of defense response|
|innate immune response|
|leukocyte mediated immunity|
|regulation of multi-organism process|
|cellular response to DNA damage stimulus|
|symbiotic process|
|interspecies interaction between organisms|
|positive regulation of immune response|
|leukocyte activation|
|defense response to other organism|
|cell activation|
|immune effector process|
|regulation of response to external stimulus|
|regulation of immune response|
|positive regulation of immune system process|
|response to abiotic stimulus|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|integral component of plasma membrane|
|regulation of response to stress|
|extracellular space|
|negative regulation of response to stimulus|
|regulation of immune system process|
|cellular response to stress|
|immune response|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp283|Glyphosate 1000μM R06 exp283]]|1.72|
|[[:results:exp521|Salinomycin 3.5μM R08 exp521]]|2.03|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8786
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.58 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MICA Expression in NALM6 Cells: 4.58'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>