MICALL2 [The Human Chemical-Genetic Interaction Map Project]

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======= MICALL2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MICALL2
  * **<color #00a2e8>Official Name</color>**: MICAL like 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=79778|79778]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8IY33|Q8IY33]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MICALL2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MICALL2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/620912|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Effector of small Rab GTPases which is involved in junctional complexes assembly through the regulation of cell adhesion molecules transport to the plasma membrane and actin cytoskeleton reorganization. Regulates the endocytic recycling of occludins, claudins and E-cadherin to the plasma membrane and may thereby regulate the establishment of tight junctions and adherens junctions. In parallel, may regulate actin cytoskeleton reorganization directly through interaction with F-actin or indirectly through actinins and filamins. Most probably involved in the processes of epithelial cell differentiation, cell spreading and neurite outgrowth (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|LIM|
|CAMSAP CH|
|CH|
|DUF3585|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|actin filament bundle|
|actinin binding|
|filamin binding|
|actin filament polymerization|
|positive regulation of protein targeting to mitochondrion|
|bicellular tight junction assembly|
|tight junction assembly|
|endocytic recycling|
|tight junction organization|
|regulation of protein targeting to mitochondrion|
|apical junction assembly|
|actin polymerization or depolymerization|
|substrate adhesion-dependent cell spreading|
|positive regulation of establishment of protein localization to mitochondrion|
|actin cytoskeleton reorganization|
|stress fiber|
|regulation of establishment of protein localization to mitochondrion|
|regulation of protein targeting|
|protein polymerization|
|cell-cell junction assembly|
|positive regulation of mitochondrion organization|
|recycling endosome|
|bicellular tight junction|
|cell-cell junction organization|
|Rab GTPase binding|
|positive regulation of intracellular protein transport|
|cell junction assembly|
|cell-cell junction|
|regulation of mitochondrion organization|
|cell-substrate adhesion|
|actin filament binding|
|positive regulation of intracellular transport|
|cell junction organization|
|endosomal transport|
|regulation of intracellular protein transport|
|actin filament organization|
|neuron projection|
|positive regulation of cellular protein localization|
|regulation of intracellular transport|
|positive regulation of protein transport|
|supramolecular fiber organization|
|positive regulation of establishment of protein localization|
|actin cytoskeleton organization|
|regulation of cellular protein localization|
|cell morphogenesis involved in differentiation|
|actin filament-based process|
|positive regulation of organelle organization|
|neuron projection development|
|regulation of protein transport|
|cell morphogenesis|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|neuron development|
|cellular component morphogenesis|
|cellular protein-containing complex assembly|
|regulation of cellular localization|
|cell adhesion|
|biological adhesion|
|positive regulation of transport|
|neuron differentiation|
|regulation of protein localization|
|cytoskeleton organization|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|positive regulation of cellular component organization|
|regulation of organelle organization|
|intracellular transport|
|generation of neurons|
|protein-containing complex assembly|
|neurogenesis|
|cell development|
|establishment of localization in cell|
|protein-containing complex subunit organization|
|regulation of transport|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp60|Vinblastine 0.002μM R01 exp60]]|-1.98|
|[[:results:exp492|iCRT14 30μM R08 exp492]]|-1.7|
|[[:results:exp80|RO-3307 4.7μM R02 exp80]]|2.34|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rrm1|RRM1]]|0.406|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2707
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -1.37 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MICALL2 Expression in NALM6 Cells: -1.37'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>