MID1 [The Human Chemical-Genetic Interaction Map Project]

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======= MID1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MID1
  * **<color #00a2e8>Official Name</color>**: midline 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4281|4281]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O15344|O15344]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MID1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MID1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/300552|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a member of the tripartite motif (TRIM) family, also known as the 'RING-B box-coiled coil' (RBCC) subgroup of RING finger proteins. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein forms homodimers which associate with microtubules in the cytoplasm. The protein is likely involved in the formation of multiprotein structures acting as anchor points to microtubules. Mutations in this gene have been associated with the X-linked form of Opitz syndrome, which is characterized by midline abnormalities such as cleft lip, laryngeal cleft, heart defects, hypospadias, and agenesis of the corpus callosum. This gene was also the first example of a gene subject to X inactivation in human while escaping it in mouse. Alternative promoter use, alternative splicing and alternative polyadenylation result in multiple transcript variants that have different tissue specificities. [provided by RefSeq, Dec 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Has E3 ubiquitin ligase activity towards IGBP1, promoting its monoubiquitination, which results in deprotection of the catalytic subunit of protein phosphatase PP2A, and its subsequent degradation by polyubiquitination. {ECO:0000269|PubMed:10400985, ECO:0000269|PubMed:11685209, ECO:0000269|PubMed:22613722}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|zf-B box|
|zf-C3HC4|
|fn3|
|SPRY|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|protein localization to microtubule|
|negative regulation of microtubule depolymerization|
|regulation of microtubule depolymerization|
|microtubule associated complex|
|protein localization to microtubule cytoskeleton|
|phosphoprotein binding|
|negative regulation of microtubule polymerization or depolymerization|
|protein localization to cytoskeleton|
|cytoplasmic microtubule|
|transferase activity|
|negative regulation of protein depolymerization|
|negative regulation of protein complex disassembly|
|interferon-gamma-mediated signaling pathway|
|regulation of microtubule polymerization or depolymerization|
|regulation of protein depolymerization|
|regulation of protein complex disassembly|
|spindle|
|negative regulation of supramolecular fiber organization|
|negative regulation of cytoskeleton organization|
|cellular response to interferon-gamma|
|positive regulation of stress-activated MAPK cascade|
|positive regulation of stress-activated protein kinase signaling cascade|
|response to interferon-gamma|
|regulation of microtubule cytoskeleton organization|
|regulation of microtubule-based process|
|regulation of stress-activated MAPK cascade|
|regulation of stress-activated protein kinase signaling cascade|
|microtubule binding|
|ubiquitin protein ligase binding|
|microtubule|
|regulation of supramolecular fiber organization|
|negative regulation of organelle organization|
|pattern specification process|
|microtubule cytoskeleton organization|
|protein heterodimerization activity|
|regulation of cytoskeleton organization|
|positive regulation of MAPK cascade|
|microtubule-based process|
|cytokine-mediated signaling pathway|
|negative regulation of cellular component organization|
|protein localization to organelle|
|regulation of cellular response to stress|
|regulation of MAPK cascade|
|innate immune response|
|zinc ion binding|
|protein homodimerization activity|
|defense response to other organism|
|cellular response to cytokine stimulus|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|positive regulation of phosphorylation|
|identical protein binding|
|response to cytokine|
|cytoskeleton organization|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|positive regulation of protein modification process|
|regulation of organelle organization|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|regulation of protein phosphorylation|
|regulation of response to stress|
|cellular protein localization|
|regulation of phosphorylation|
|cellular macromolecule localization|
|positive regulation of cellular protein metabolic process|
|positive regulation of signal transduction|
|positive regulation of protein metabolic process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|immune response|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|-2.2|
|[[:results:exp111|R-DABN 8μM R03 exp111]]|-1.87|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|1.8|
|[[:results:exp233|EPZ-5676 30μM R05 exp233]]|1.81|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/694
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/26|
|bone|0/26|
|breast|0/30|
|central nervous system|0/49|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/11|
|fibroblast|0/1|
|gastric|0/14|
|kidney|0/18|
|liver|0/19|
|lung|0/72|
|lymphocyte|0/16|
|ovary|0/25|
|pancreas|0/22|
|peripheral nervous system|0/15|
|plasma cell|0/12|
|prostate|0/1|
|skin|0/20|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/28|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 18678
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.47 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MID1 Expression in NALM6 Cells: 1.47'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>