MIER3 [The Human Chemical-Genetic Interaction Map Project]

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======= MIER3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MIER3
  * **<color #00a2e8>Official Name</color>**: MIER family member 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=166968|166968]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q7Z3K6|Q7Z3K6]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MIER3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MIER3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/620100|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Transcriptional repressor. {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|ELM2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|histone deacetylase activity|
|RNA polymerase II repressing transcription factor binding|
|histone deacetylation|
|protein deacetylation|
|protein deacylation|
|macromolecule deacylation|
|histone deacetylase binding|
|transcription corepressor activity|
|histone modification|
|covalent chromatin modification|
|protein-containing complex|
|chromatin organization|
|negative regulation of transcription by RNA polymerase II|
|chromosome organization|
|negative regulation of transcription, DNA-templated|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of RNA metabolic process|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|DNA binding|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|negative regulation of biosynthetic process|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|negative regulation of gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp211|AICAR 240μM R05 exp211]]|-2.16|
|[[:results:exp349|Cytochalasin-B 5μM R07 exp349]]|-1.98|
|[[:results:exp414|Tozasertib 0.1μM R07 exp414]]|-1.92|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|-1.89|
|[[:results:exp527|Tanespimycin 14μM R08 exp527]]|-1.86|
|[[:results:exp510|Nicotine 3000μM R08 exp510]]|1.7|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|1.72|
|[[:results:exp124|GSK343 3μM R03 exp124]]|1.73|
|[[:results:exp30|Rapamycin 10μM R00 exp30]]|1.73|
|[[:results:exp79|Q15 2.7μM R02 exp79]]|1.74|
|[[:results:exp70|INK128 0.2μM R02 exp70]]|1.75|
|[[:results:exp114|A-196 10μM R03 exp114]]|1.76|
|[[:results:exp99|NFN1 0.4μM R03 exp99]]|1.77|
|[[:results:exp8|Brefeldin A 0.02μM R00 exp8]]|1.78|
|[[:results:exp426|FBS-Wisent 0.1 R07 exp426]]|1.82|
|[[:results:exp16|DABN 2μM R00 exp16]]|2.02|
|[[:results:exp159|Docetaxel 0.001 to 0.002μM on day4 R04 exp159]]|2.02|
|[[:results:exp190|Vincristine 0.0005μM R04 exp190]]|2.24|
|[[:results:exp340|BN82002 4μM R07 exp340]]|2.42|
|[[:results:exp89|Vemurafenib 6.6μM R02 exp89]]|2.65|
|[[:results:exp1|5-Fluorouracil 2μM R00 exp1]]|2.73|
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|2.81|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:b:bcl2l1|BCL2L1]]|0.409|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8614
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.2 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MIER3 Expression in NALM6 Cells: 6.2'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>