MIS18BP1 [The Human Chemical-Genetic Interaction Map Project]

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======= MIS18BP1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MIS18BP1
  * **<color #00a2e8>Official Name</color>**: MIS18 binding protein 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=55320|55320]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q6P0N0|Q6P0N0]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MIS18BP1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MIS18BP1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/618139|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis. {ECO:0000269|PubMed:17199038, ECO:0000269|PubMed:17339379}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|SANTA|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|condensed nuclear chromosome kinetochore|
|CENP-A containing chromatin organization|
|CENP-A containing nucleosome assembly|
|chromatin remodeling at centromere|
|centromere complex assembly|
|DNA replication-independent nucleosome assembly|
|DNA replication-independent nucleosome organization|
|histone exchange|
|ATP-dependent chromatin remodeling|
|nucleosome assembly|
|chromatin assembly|
|chromatin assembly or disassembly|
|nucleosome organization|
|chromatin remodeling|
|DNA packaging|
|protein-DNA complex assembly|
|protein-DNA complex subunit organization|
|DNA conformation change|
|cell division|
|chromatin organization|
|cellular protein-containing complex assembly|
|chromosome organization|
|cell cycle|
|DNA binding|
|protein-containing complex assembly|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp232|Epothilone-D 0.004 to 0.006μM on day4 R05 exp232]]|-1.93|
|[[:results:exp494|Isoniazid 100μM R08 exp494]]|-1.81|
|[[:results:exp95|BI-2536 0.0042μM R03 exp95]]|-1.8|
|[[:results:exp160|Ribavirin 10 to 15μM on day4 R04 exp160]]|-1.78|
|[[:results:exp8|Brefeldin A 0.02μM R00 exp8]]|1.94|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 636/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|23/28|
|blood|25/28|
|bone|21/25|
|breast|29/33|
|central nervous system|53/56|
|cervix|4/4|
|colorectal|17/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|9/15|
|kidney|19/21|
|liver|17/20|
|lung|68/75|
|lymphocyte|9/14|
|ovary|25/26|
|pancreas|24/24|
|peripheral nervous system|12/16|
|plasma cell|14/15|
|prostate|0/1|
|skin|20/24|
|soft tissue|6/7|
|thyroid|2/2|
|upper aerodigestive|21/22|
|urinary tract|24/29|
|uterus|3/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 860
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.17 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MIS18BP1 Expression in NALM6 Cells: 7.17'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>