MLLT6 [The Human Chemical-Genetic Interaction Map Project]

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======= MLLT6 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MLLT6
  * **<color #00a2e8>Official Name</color>**: MLLT6, PHD finger containing
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4302|4302]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P55198|P55198]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MLLT6&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MLLT6|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600328|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PHD|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of histone H3-K79 methylation|
|renal potassium excretion|
|renal sodium excretion|
|regulation of histone H3-K79 methylation|
|negative regulation of urine volume|
|negative regulation of histone methylation|
|regulation of urine volume|
|nucleosome binding|
|sodium ion homeostasis|
|positive regulation of sodium ion transport|
|negative regulation of histone modification|
|excretion|
|negative regulation of chromatin organization|
|regulation of histone methylation|
|regulation of sodium ion transport|
|renal system process|
|histone binding|
|negative regulation of chromosome organization|
|monovalent inorganic cation homeostasis|
|regulation of histone modification|
|regulation of chromatin organization|
|positive regulation of ion transport|
|regulation of chromosome organization|
|negative regulation of organelle organization|
|regulation of metal ion transport|
|regulation of body fluid levels|
|negative regulation of protein modification process|
|metal ion homeostasis|
|regulation of ion transport|
|negative regulation of cellular component organization|
|cation homeostasis|
|inorganic ion homeostasis|
|ion homeostasis|
|positive regulation of transport|
|negative regulation of cellular protein metabolic process|
|negative regulation of protein metabolic process|
|chemical homeostasis|
|positive regulation of transcription by RNA polymerase II|
|regulation of organelle organization|
|positive regulation of transcription, DNA-templated|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|homeostatic process|
|positive regulation of RNA metabolic process|
|regulation of protein modification process|
|regulation of transport|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|system process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp156|UNC2400 2μM R03 exp156]]|1.76|
|[[:results:exp182|IU1-47 25μM R04 exp182]]|1.86|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2660
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.92 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MLLT6 Expression in NALM6 Cells: 7.92'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>