MMP16 [The Human Chemical-Genetic Interaction Map Project]

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======= MMP16 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MMP16
  * **<color #00a2e8>Official Name</color>**: matrix metallopeptidase 16
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4325|4325]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P51512|P51512]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MMP16&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MMP16|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602262|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Endopeptidase that degrades various components of the extracellular matrix, such as collagen type III and fibronectin. Activates progelatinase A. Involved in the matrix remodeling of blood vessels. Isoform short cleaves fibronectin and also collagen type III, but at lower rate. It has no effect on type I, II, IV and V collagen. However, upon interaction with CSPG4, it may be involved in degradation and invasion of type I collagen by melanoma cells. {ECO:0000269|PubMed:11278606}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Hemopexin|
|PG binding 1|
|DUF3377|
|Peptidase M10|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|chondrocyte proliferation|
|craniofacial suture morphogenesis|
|metalloaminopeptidase activity|
|endochondral ossification|
|replacement ossification|
|collagen catabolic process|
|embryonic cranial skeleton morphogenesis|
|enzyme activator activity|
|extracellular matrix disassembly|
|collagen metabolic process|
|cranial skeletal system development|
|endochondral bone morphogenesis|
|embryonic skeletal system morphogenesis|
|Golgi lumen|
|metalloendopeptidase activity|
|bone morphogenesis|
|embryonic skeletal system development|
|protein processing|
|bone development|
|protein maturation|
|extracellular matrix|
|skeletal system morphogenesis|
|ossification|
|embryonic organ morphogenesis|
|extracellular matrix organization|
|extracellular structure organization|
|cellular component disassembly|
|embryonic organ development|
|skeletal system development|
|cell population proliferation|
|embryonic morphogenesis|
|cell surface|
|chordate embryonic development|
|embryo development ending in birth or egg hatching|
|zinc ion binding|
|animal organ morphogenesis|
|embryo development|
|proteolysis|
|integral component of plasma membrane|
|positive regulation of catalytic activity|
|extracellular space|
|positive regulation of molecular function|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp11|CCCP 1μM R00 exp11]]|1.88|
|[[:results:exp122|Golgicide-A 4μM R03 exp122]]|1.97|
|[[:results:exp15|Cycloheximide 0.2μM R00 exp15]]|2.11|
|[[:results:exp133|MKC9989 10μM R03 exp133]]|2.27|
|[[:results:exp7|Bortezomib 0.05μM R00 exp7]]|2.49|
|[[:results:exp37|Wortmannin 0.5μM R00 exp37]]|2.53|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13327
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -2.51 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MMP16 Expression in NALM6 Cells: -2.51'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>