MMS22L [The Human Chemical-Genetic Interaction Map Project]

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======= MMS22L =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MMS22L
  * **<color #00a2e8>Official Name</color>**: MMS22 like, DNA repair protein
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=253714|253714]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q6ZRQ5|Q6ZRQ5]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MMS22L&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MMS22L|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/615614|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Component of the MMS22L-TONSL complex, a complex that stimulates the recombination-dependent repair of stalled or collapsed replication forks. The MMS22L-TONSL complex is required to maintain genome integrity during DNA replication by promoting homologous recombination-mediated repair of replication fork- associated double-strand breaks. It may act by mediating the assembly of RAD51 filaments on ssDNA. {ECO:0000269|PubMed:21055983, ECO:0000269|PubMed:21055984, ECO:0000269|PubMed:21055985}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|FACT complex|
|nuclear replication fork|
|MCM complex|
|replication fork processing|
|DNA-dependent DNA replication maintenance of fidelity|
|double-strand break repair via homologous recombination|
|recombinational repair|
|DNA-dependent DNA replication|
|double-strand break repair|
|DNA replication|
|DNA recombination|
|DNA repair|
|DNA metabolic process|
|cellular response to DNA damage stimulus|
|cellular response to stress|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp199|Etoposide 0.3μM R05 exp199]]|-1.72|
|[[:results:exp51|Nifuroxazide 1μM R01 exp51]]|1.8|
|[[:results:exp421|VHL-ligand-1 20μM R07 exp421]]|1.84|
|[[:results:exp183|IU1-C 25μM R04 exp183]]|1.9|
|[[:results:exp49|NFN1 0.1μM R01 exp49]]|1.91|
|[[:results:exp347|Cyclosporin-A 0.8μM R07 exp347]]|1.94|
|[[:results:exp233|EPZ-5676 30μM R05 exp233]]|2|
|[[:results:exp165|RO-3306 3 to 4μM on day4 R04 exp165]]|2.07|
|[[:results:exp169|BH1 1μM R04 exp169]]|2.12|
|[[:results:exp112|S-DABN 8μM R03 exp112]]|2.19|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:polr2j3|POLR2J3]]|0.537|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.498|
|[[:human genes:p:psma6|PSMA6]]|0.494|
|[[:human genes:c:ccna2|CCNA2]]|0.475|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.473|
|[[:human genes:t:tbc1d3|TBC1D3]]|0.457|
|[[:human genes:p:psmc2|PSMC2]]|0.456|
|[[:human genes:p:psmc1|PSMC1]]|0.445|
|[[:human genes:c:cln6|CLN6]]|0.444|
|[[:human genes:s:slc4a1|SLC4A1]]|0.439|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.437|
|[[:human genes:c:chd4|CHD4]]|0.434|
|[[:human genes:t:tbc1d3c|TBC1D3C]]|0.432|
|[[:human genes:a:atp6v1c1|ATP6V1C1]]|0.431|
|[[:human genes:t:tonsl|TONSL]]|0.428|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.425|
|[[:human genes:s:sh3bp1|SH3BP1]]|0.425|
|[[:human genes:d:dtl|DTL]]|0.424|
|[[:human genes:v:vasn|VASN]]|0.424|
|[[:human genes:p:pole|POLE]]|0.424|
|[[:human genes:f:fam86b2|FAM86B2]]|0.422|
|[[:human genes:n:napa|NAPA]]|0.422|
|[[:human genes:m:myo1h|MYO1H]]|0.421|
|[[:human genes:t:tceb3c|TCEB3C]]|0.42|
|[[:human genes:z:zfand5|ZFAND5]]|0.418|
|[[:human genes:r:rrp7a|RRP7A]]|0.417|
|[[:human genes:f:fam160a1|FAM160A1]]|0.416|
|[[:human genes:m:mt1e|MT1E]]|0.414|
|[[:human genes:p:prpf19|PRPF19]]|0.412|
|[[:human genes:g:golga8o|GOLGA8O]]|0.412|
|[[:human genes:c:cdca3|CDCA3]]|0.41|
|[[:human genes:s:supt5h|SUPT5H]]|0.407|
|[[:human genes:u:utp3|UTP3]]|0.407|
|[[:human genes:t:tfip11|TFIP11]]|0.407|
|[[:human genes:c:c14orf93|C14orf93]]|0.406|
|[[:human genes:z:znf106|ZNF106]]|0.406|
|[[:human genes:r:rad51|RAD51]]|0.406|
|[[:human genes:c:cdc45|CDC45]]|0.405|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.405|
|[[:human genes:s:snrpa1|SNRPA1]]|0.404|
|[[:human genes:r:rpl6|RPL6]]|0.403|
|[[:human genes:t:tbc1d3i|TBC1D3I]]|0.403|
|[[:human genes:s:ssh2|SSH2]]|0.402|
|[[:human genes:e:exosc5|EXOSC5]]|0.402|
|[[:human genes:t:tbc1d3e|TBC1D3E]]|0.402|
|[[:human genes:t:tbc1d3l|TBC1D3L]]|0.402|
|[[:human genes:t:tbc1d3k|TBC1D3K]]|0.402|
|[[:human genes:c:cdh24|CDH24]]|0.401|
|[[:human genes:c:ccdc64b|CCDC64B]]|0.401|
|[[:human genes:m:mylk3|MYLK3]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 734/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|28/28|
|blood|28/28|
|bone|26/26|
|breast|32/33|
|central nervous system|56/56|
|cervix|4/4|
|colorectal|17/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|16/16|
|kidney|21/21|
|liver|20/20|
|lung|75/75|
|lymphocyte|16/16|
|ovary|26/26|
|pancreas|24/24|
|peripheral nervous system|16/16|
|plasma cell|15/15|
|prostate|1/1|
|skin|24/24|
|soft tissue|9/9|
|thyroid|2/2|
|upper aerodigestive|22/22|
|urinary tract|29/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 924
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.14 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MMS22L Expression in NALM6 Cells: 7.14'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>