MOGS [The Human Chemical-Genetic Interaction Map Project]

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======= MOGS =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MOGS
  * **<color #00a2e8>Official Name</color>**: mannosyl-oligosaccharide glucosidase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=7841|7841]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q13724|Q13724]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MOGS&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MOGS|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601336|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes the first enzyme in the N-linked oligosaccharide processing pathway. The enzyme cleaves the distal alpha-1,2-linked glucose residue from the Glc(3)-Man(9)-GlcNAc(2) oligosaccharide precursor. This protein is located in the lumen of the endoplasmic reticulum. Defects in this gene are a cause of type IIb congenital disorder of glycosylation (CDGIIb). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Cleaves the distal alpha 1,2-linked glucose residue from the Glc(3)Man(9)GlcNAc(2) oligosaccharide precursor in a highly specific manner.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Glyco hydro 63|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|mannosyl-oligosaccharide glucosidase activity|
|glucosidase activity|
|oligosaccharide metabolic process|
|protein N-linked glycosylation|
|protein folding|
|macromolecule glycosylation|
|protein glycosylation|
|glycosylation|
|glycoprotein biosynthetic process|
|glycoprotein metabolic process|
|carbohydrate metabolic process|
|carbohydrate derivative biosynthetic process|
|endoplasmic reticulum membrane|
|endoplasmic reticulum|
|carbohydrate derivative metabolic process|
|organonitrogen compound biosynthetic process|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp413|THZ531 0.11 to 0.175μM on day4 R07 exp413]]|-1.9|
|[[:results:exp449|Arsenic trioxide 60μM R08 exp449]]|1.7|
|[[:results:exp164|Q15 1 to 2μM on day4 R04 exp164]]|1.79|
|[[:results:exp400|Senexin-A 25μM R07 exp400]]|1.81|
|[[:results:exp1|5-Fluorouracil 2μM R00 exp1]]|1.89|
|[[:results:exp306|Rapamycin 2μM R07 exp306]]|1.89|
|[[:results:exp47|Lapatinib 5μM R01 exp47]]|1.94|
|[[:results:exp58|UM131593 0.1μM R01 exp58]]|1.99|
|[[:results:exp291|LLY-284 2.6μM R06 exp291]]|2.07|
|[[:results:exp222|Betulinic acid 10 to 15μM on day4 R05 exp222]]|2.15|
|[[:results:exp68|Clomiphene 4.4μM R02 exp68]]|2.17|
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|2.3|
|[[:results:exp320|ABT-702 5μM plus CoCl2 18μM R07 exp320]]|2.68|
|[[:results:exp346|CoCl2 18μM R07 exp346]]|2.69|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:prkcsh|PRKCSH]]|0.407|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1833
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.8 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MOGS Expression in NALM6 Cells: 6.8'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>