MORC2 [The Human Chemical-Genetic Interaction Map Project]

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======= MORC2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MORC2
  * **<color #00a2e8>Official Name</color>**: MORC family CW-type zinc finger 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=22880|22880]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y6X9|Q9Y6X9]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MORC2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MORC2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/616661|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the Microrchidia (MORC) protein superfamily. The encoded protein is known to regulate the condensation of heterochromatin in response to DNA damage and play a role in repressing transcription. The protein has been found to regulate the activity of ATP citrate lyase via specific interaction with this enzyme in the cytosol of lipogenic breast cancer cells. The protein also plays a role in lipogenesis and adipocyte differentiation. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Exhibits a cytosolic function in lipogenesis, adipogenic differentiation, and lipid homeostasis by increasing the activity of ACLY, possibly preventing its dephosphorylation (PubMed:24286864). May act as a transcriptional repressor (PubMed:20225202). Down-regulates CA9 expression (PubMed:20110259). {ECO:0000269|PubMed:20110259, ECO:0000269|PubMed:20225202, ECO:0000269|PubMed:24286864}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|zf-CW|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of methylation-dependent chromatin silencing|
|regulation of methylation-dependent chromatin silencing|
|negative regulation of single stranded viral RNA replication via double stranded DNA intermediate|
|positive regulation of chromatin silencing|
|regulation of single stranded viral RNA replication via double stranded DNA intermediate|
|heterochromatin|
|regulation of chromatin silencing|
|negative regulation of viral genome replication|
|negative regulation of gene expression, epigenetic|
|negative regulation of viral life cycle|
|regulation of viral genome replication|
|negative regulation of viral process|
|positive regulation of chromatin organization|
|nuclear matrix|
|regulation of gene silencing|
|regulation of viral life cycle|
|chromatin remodeling|
|positive regulation of chromosome organization|
|regulation of chromatin organization|
|regulation of viral process|
|magnesium ion binding|
|negative regulation of multi-organism process|
|regulation of symbiosis, encompassing mutualism through parasitism|
|ATPase activity|
|regulation of gene expression, epigenetic|
|fatty acid metabolic process|
|regulation of chromosome organization|
|chromatin binding|
|monocarboxylic acid metabolic process|
|positive regulation of organelle organization|
|chromatin organization|
|cellular response to DNA damage stimulus|
|regulation of multi-organism process|
|zinc ion binding|
|protein homodimerization activity|
|carboxylic acid metabolic process|
|cellular lipid metabolic process|
|oxoacid metabolic process|
|organic acid metabolic process|
|chromosome organization|
|positive regulation of cellular component organization|
|lipid metabolic process|
|regulation of organelle organization|
|ATP binding|
|cellular response to stress|
|negative regulation of gene expression|
|small molecule metabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp330|5-Azacytidine 2μM R07 exp330]]|-2|
|[[:results:exp485|GSK626616 14μM R08 exp485]]|-1.75|
|[[:results:exp374|Latrunculin-B 10μM R07 exp374]]|-1.74|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|1.91|
|[[:results:exp230|Epigallocatechin gallate 20μM R05 exp230]]|2.1|
|[[:results:exp162|BI-D1870 2μM R04 exp162]]|2.21|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:f:fam208a|FAM208A]]|0.49|
|[[:human genes:c:cbwd3|CBWD3]]|0.418|
|[[:human genes:z:zfand5|ZFAND5]]|0.417|
|[[:human genes:f:fbxw9|FBXW9]]|0.416|
|[[:human genes:m:med14|MED14]]|0.406|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1952
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.26 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MORC2 Expression in NALM6 Cells: 5.26'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>