MOV10 [The Human Chemical-Genetic Interaction Map Project]

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======= MOV10 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MOV10
  * **<color #00a2e8>Official Name</color>**: Mov10 RISC complex RNA helicase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4343|4343]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9HCE1|Q9HCE1]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MOV10&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MOV10|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/610742|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Probable RNA helicase. Required for miRNA-mediated gene silencing by the RNA-induced silencing complex (RISC). Required for both miRNA-mediated translational repression and miRNA- mediated cleavage of complementary mRNAs by RISC. {ECO:0000269|PubMed:16289642, ECO:0000269|PubMed:17507929, ECO:0000269|PubMed:22791714}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|5-3 RNA helicase activity|
|negative regulation of transposition, RNA-mediated|
|regulation of transposition, RNA-mediated|
|mRNA cleavage involved in gene silencing by miRNA|
|mRNA cleavage involved in gene silencing|
|regulation of neuron projection arborization|
|3-UTR-mediated mRNA destabilization|
|P granule|
|negative regulation of transposition|
|regulation of transposition|
|mRNA cleavage|
|mRNA destabilization|
|RNA destabilization|
|Wnt signaling pathway, calcium modulating pathway|
|gene silencing by miRNA|
|positive regulation of mRNA catabolic process|
|regulation of megakaryocyte differentiation|
|posttranscriptional gene silencing by RNA|
|posttranscriptional gene silencing|
|cytoplasmic stress granule|
|cytoplasmic ribonucleoprotein granule|
|positive regulation of mRNA metabolic process|
|P-body|
|gene silencing by RNA|
|negative regulation of translation|
|non-canonical Wnt signaling pathway|
|negative regulation of cellular amide metabolic process|
|gene silencing|
|RNA phosphodiester bond hydrolysis|
|regulation of mRNA stability|
|regulation of RNA stability|
|regulation of mRNA catabolic process|
|regulation of myeloid cell differentiation|
|regulation of gene expression, epigenetic|
|nucleic acid phosphodiester bond hydrolysis|
|regulation of mRNA metabolic process|
|regulation of translation|
|cell-cell signaling by wnt|
|Wnt signaling pathway|
|positive regulation of cellular catabolic process|
|regulation of cellular amide metabolic process|
|cell surface receptor signaling pathway involved in cell-cell signaling|
|positive regulation of catabolic process|
|regulation of hemopoiesis|
|regulation of cell morphogenesis|
|regulation of neuron projection development|
|posttranscriptional regulation of gene expression|
|regulation of neuron differentiation|
|mRNA metabolic process|
|regulation of plasma membrane bounded cell projection organization|
|regulation of cell projection organization|
|regulation of neurogenesis|
|regulation of cellular catabolic process|
|regulation of nervous system development|
|regulation of cell development|
|regulation of catabolic process|
|negative regulation of cellular protein metabolic process|
|regulation of anatomical structure morphogenesis|
|negative regulation of protein metabolic process|
|cell-cell signaling|
|negative regulation of cellular macromolecule biosynthetic process|
|RNA binding|
|negative regulation of macromolecule biosynthetic process|
|ATP binding|
|negative regulation of cellular biosynthetic process|
|generation of neurons|
|negative regulation of biosynthetic process|
|extracellular space|
|neurogenesis|
|regulation of immune system process|
|RNA metabolic process|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|regulation of cell differentiation|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4588
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.45 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MOV10 Expression in NALM6 Cells: 6.45'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>