MPC2 [The Human Chemical-Genetic Interaction Map Project]

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======= MPC2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MPC2
  * **<color #00a2e8>Official Name</color>**: mitochondrial pyruvate carrier 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=25874|25874]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O95563|O95563]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MPC2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MPC2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/614737|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Mediates the uptake of pyruvate into mitochondria. {ECO:0000269|PubMed:22628558}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|UPF0041|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|mitochondrial pyruvate transmembrane transport|
|pyruvate transport|
|pyruvate transmembrane transporter activity|
|pyruvate transmembrane transport|
|mitochondrial acetyl-CoA biosynthetic process from pyruvate|
|acetyl-CoA biosynthetic process from pyruvate|
|acetyl-CoA biosynthetic process|
|acetyl-CoA metabolic process|
|positive regulation of insulin secretion involved in cellular response to glucose stimulus|
|integral component of mitochondrial inner membrane|
|acyl-CoA biosynthetic process|
|thioester biosynthetic process|
|regulation of insulin secretion involved in cellular response to glucose stimulus|
|ribonucleoside bisphosphate biosynthetic process|
|nucleoside bisphosphate biosynthetic process|
|purine nucleoside bisphosphate biosynthetic process|
|pyruvate metabolic process|
|positive regulation of insulin secretion|
|mitochondrial transmembrane transport|
|thioester metabolic process|
|positive regulation of peptide hormone secretion|
|acyl-CoA metabolic process|
|carboxylic acid transmembrane transport|
|positive regulation of hormone secretion|
|organic acid transmembrane transport|
|nucleoside bisphosphate metabolic process|
|purine nucleoside bisphosphate metabolic process|
|ribonucleoside bisphosphate metabolic process|
|coenzyme biosynthetic process|
|monocarboxylic acid transport|
|purine ribonucleotide biosynthetic process|
|purine nucleotide biosynthetic process|
|ribonucleotide biosynthetic process|
|ribose phosphate biosynthetic process|
|purine-containing compound biosynthetic process|
|regulation of insulin secretion|
|sulfur compound biosynthetic process|
|regulation of peptide hormone secretion|
|cofactor biosynthetic process|
|mitochondrial transport|
|nucleotide biosynthetic process|
|nucleoside phosphate biosynthetic process|
|coenzyme metabolic process|
|regulation of hormone secretion|
|positive regulation of protein secretion|
|anion transmembrane transport|
|positive regulation of peptide secretion|
|organic acid transport|
|carboxylic acid transport|
|purine ribonucleotide metabolic process|
|ribonucleotide metabolic process|
|purine nucleotide metabolic process|
|ribose phosphate metabolic process|
|sulfur compound metabolic process|
|purine-containing compound metabolic process|
|positive regulation of secretion by cell|
|positive regulation of protein transport|
|positive regulation of secretion|
|cofactor metabolic process|
|nucleotide metabolic process|
|nucleoside phosphate metabolic process|
|organic anion transport|
|positive regulation of establishment of protein localization|
|regulation of protein secretion|
|regulation of peptide secretion|
|amide biosynthetic process|
|monocarboxylic acid metabolic process|
|regulation of hormone levels|
|organophosphate biosynthetic process|
|nucleobase-containing small molecule metabolic process|
|anion transport|
|carbohydrate derivative biosynthetic process|
|regulation of protein transport|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|cellular amide metabolic process|
|regulation of secretion|
|organophosphate metabolic process|
|carboxylic acid metabolic process|
|regulation of cellular localization|
|ion transmembrane transport|
|positive regulation of transport|
|oxoacid metabolic process|
|organic acid metabolic process|
|regulation of protein localization|
|carbohydrate derivative metabolic process|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|mitochondrion|
|transmembrane transport|
|organic cyclic compound biosynthetic process|
|ion transport|
|organonitrogen compound biosynthetic process|
|cellular nitrogen compound biosynthetic process|
|small molecule metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp410|THZ531 0.11 to 0.125μM on day4 R07 exp410]]|1.71|
|[[:results:exp224|CB-839 10μM R05 exp224]]|1.74|
|[[:results:exp346|CoCl2 18μM R07 exp346]]|1.91|
|[[:results:exp15|Cycloheximide 0.2μM R00 exp15]]|2.17|
|[[:results:exp38|Wortmannin 5μM R00 exp38]]|2.63|
|[[:results:exp102|Nifuroxazide 5μM R03 exp102]]|5.15|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:m:mpc1|MPC1]]|0.536|
|[[:human genes:p:pdhb|PDHB]]|0.449|
|[[:human genes:h:hgc6.3|HGC6.3]]|0.434|
|[[:human genes:p:pdp1|PDP1]]|0.433|
|[[:human genes:p:pdha1|PDHA1]]|0.417|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7703
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.77 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MPC2 Expression in NALM6 Cells: 4.77'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>