MPI [The Human Chemical-Genetic Interaction Map Project]

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======= MPI =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MPI
  * **<color #00a2e8>Official Name</color>**: mannose phosphate isomerase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4351|4351]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P34949|P34949]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MPI&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MPI|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/154550|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Phosphomannose isomerase catalyzes the interconversion of fructose-6-phosphate and mannose-6-phosphate and plays a critical role in maintaining the supply of D-mannose derivatives, which are required for most glycosylation reactions. Mutations in the MPI gene were found in patients with carbohydrate-deficient glycoprotein syndrome, type Ib. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PMI typeI|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cell wall mannoprotein biosynthetic process|
|mannoprotein metabolic process|
|cell wall biogenesis|
|cellular component macromolecule biosynthetic process|
|mannose-6-phosphate isomerase activity|
|cell wall macromolecule biosynthetic process|
|cell wall glycoprotein biosynthetic process|
|mannose to fructose-6-phosphate metabolic process|
|mannoprotein biosynthetic process|
|cell wall macromolecule metabolic process|
|GDP-mannose biosynthetic process|
|cell wall organization or biogenesis|
|GDP-mannose metabolic process|
|mannose metabolic process|
|nucleotide-sugar biosynthetic process|
|nucleotide-sugar metabolic process|
|hexose metabolic process|
|monosaccharide metabolic process|
|macromolecule glycosylation|
|protein glycosylation|
|glycosylation|
|glycoprotein biosynthetic process|
|glycoprotein metabolic process|
|carbohydrate metabolic process|
|nucleobase-containing small molecule metabolic process|
|carbohydrate derivative biosynthetic process|
|zinc ion binding|
|carbohydrate derivative metabolic process|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|organic cyclic compound biosynthetic process|
|organonitrogen compound biosynthetic process|
|cellular nitrogen compound biosynthetic process|
|cellular macromolecule biosynthetic process|
|small molecule metabolic process|
|macromolecule biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp452|Azithromycin 100μM R08 exp452]]|-2.11|
|[[:results:exp214|2-Deoxy-D-glucose 800μM R05 exp214]]|-2.01|
|[[:results:exp464|Calcipotriol 5μM R08 exp464]]|-1.97|
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|-1.81|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|1.84|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|1/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6414
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.11 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MPI Expression in NALM6 Cells: 6.11'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>