MPL [The Human Chemical-Genetic Interaction Map Project]

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======= MPL =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MPL
  * **<color #00a2e8>Official Name</color>**: MPL proto-oncogene, thrombopoietin receptor
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4352|4352]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P40238|P40238]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MPL&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MPL|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/159530|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  In 1990 an oncogene, v-mpl, was identified from the murine myeloproliferative leukemia virus that was capable of immortalizing bone marrow hematopoietic cells from different lineages. In 1992 the human homologue, named, c-mpl, was cloned. Sequence data revealed that c-mpl encoded a protein that was homologous with members of the hematopoietic receptor superfamily. Presence of anti-sense oligodeoxynucleotides of c-mpl inhibited megakaryocyte colony formation. The ligand for c-mpl, thrombopoietin, was cloned in 1994. Thrombopoietin was shown to be the major regulator of megakaryocytopoiesis and platelet formation. The protein encoded by the c-mpl gene, CD110, is a 635 amino acid transmembrane domain, with two extracellular cytokine receptor domains and two intracellular cytokine receptor box motifs . TPO-R deficient mice were severely thrombocytopenic, emphasizing the important role of CD110 and thrombopoietin in megakaryocyte and platelet formation. Upon binding of thrombopoietin CD110 is dimerized and the JAK family of non-receptor tyrosine kinases, as well as the STAT family, the MAPK family, the adaptor protein Shc and the receptors themselves become tyrosine phosphorylated. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Receptor for thrombopoietin. May represent a regulatory molecule specific for TPO-R-dependent immune responses.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|EpoR lig-bind|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|thrombopoietin receptor activity|
|eosinophil homeostasis|
|positive regulation of platelet formation|
|basophil homeostasis|
|regulation of platelet formation|
|monocyte homeostasis|
|thrombopoietin-mediated signaling pathway|
|neutrophil homeostasis|
|platelet aggregation|
|homotypic cell-cell adhesion|
|leukocyte homeostasis|
|chemokine-mediated signaling pathway|
|cellular response to chemokine|
|response to chemokine|
|positive regulation of myeloid cell differentiation|
|myeloid cell homeostasis|
|positive regulation of lymphocyte proliferation|
|positive regulation of mononuclear cell proliferation|
|positive regulation of leukocyte proliferation|
|platelet activation|
|positive regulation of cell morphogenesis involved in differentiation|
|positive regulation of hemopoiesis|
|cellular response to hypoxia|
|cellular response to decreased oxygen levels|
|homeostasis of number of cells|
|regulation of lymphocyte proliferation|
|regulation of mononuclear cell proliferation|
|cellular response to oxygen levels|
|regulation of leukocyte proliferation|
|regulation of myeloid cell differentiation|
|blood coagulation|
|coagulation|
|hemostasis|
|regulation of cell morphogenesis involved in differentiation|
|neuron projection|
|response to hypoxia|
|response to decreased oxygen levels|
|positive regulation of lymphocyte activation|
|neuronal cell body|
|response to oxygen levels|
|positive regulation of leukocyte activation|
|positive regulation of cell activation|
|regulation of hemopoiesis|
|wound healing|
|regulation of cell morphogenesis|
|regulation of body fluid levels|
|cell-cell adhesion|
|regulation of lymphocyte activation|
|positive regulation of cell development|
|response to wounding|
|regulation of leukocyte activation|
|cell surface|
|regulation of cell activation|
|cytokine-mediated signaling pathway|
|positive regulation of cell population proliferation|
|cell adhesion|
|regulation of cell development|
|biological adhesion|
|positive regulation of cell differentiation|
|Golgi apparatus|
|cellular response to cytokine stimulus|
|regulation of anatomical structure morphogenesis|
|cell activation|
|response to cytokine|
|positive regulation of immune system process|
|response to abiotic stimulus|
|positive regulation of cellular component organization|
|positive regulation of developmental process|
|regulation of cell population proliferation|
|homeostatic process|
|regulation of immune system process|
|cellular response to stress|
|positive regulation of multicellular organismal process|
|regulation of cell differentiation|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 2/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|2/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3466
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -3.59 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MPL Expression in NALM6 Cells: -3.59'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>