MPO [The Human Chemical-Genetic Interaction Map Project]

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======= MPO =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MPO
  * **<color #00a2e8>Official Name</color>**: myeloperoxidase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4353|4353]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P05164|P05164]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MPO&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MPO|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606989|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Myeloperoxidase (MPO) is a heme protein synthesized during myeloid differentiation that constitutes the major component of neutrophil azurophilic granules. Produced as a single chain precursor, myeloperoxidase is subsequently cleaved into a light and heavy chain. The mature myeloperoxidase is a tetramer composed of 2 light chains and 2 heavy chains. This enzyme produces hypohalous acids central to the microbicidal activity of neutrophils. [provided by RefSeq, Nov 2014]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Part of the host defense system of polymorphonuclear leukocytes. It is responsible for microbicidal activity against a wide range of organisms. In the stimulated PMN, MPO catalyzes the production of hypohalous acids, primarily hypochlorous acid in physiologic situations, and other toxic intermediates that greatly enhance PMN microbicidal activity. {ECO:0000269|PubMed:9922160}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|An peroxidase|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|hypochlorous acid biosynthetic process|
|response to gold nanoparticle|
|hypochlorous acid metabolic process|
|response to transition metal nanoparticle|
|response to yeast|
|phagocytic vesicle lumen|
|respiratory burst involved in defense response|
|azurophil granule|
|removal of superoxide radicals|
|low-density lipoprotein particle remodeling|
|cellular response to superoxide|
|cellular response to oxygen radical|
|response to superoxide|
|response to oxygen radical|
|respiratory burst|
|response to food|
|reactive oxygen species biosynthetic process|
|hydrogen peroxide catabolic process|
|plasma lipoprotein particle remodeling|
|protein-lipid complex remodeling|
|protein-containing complex remodeling|
|peroxidase activity|
|defense response to fungus|
|hydrogen peroxide metabolic process|
|superoxide metabolic process|
|plasma lipoprotein particle organization|
|protein-lipid complex subunit organization|
|response to fungus|
|antibiotic catabolic process|
|cofactor catabolic process|
|regulation of plasma lipoprotein particle levels|
|cell redox homeostasis|
|secretory granule|
|cellular oxidant detoxification|
|azurophil granule lumen|
|cellular detoxification|
|antibiotic metabolic process|
|reactive oxygen species metabolic process|
|detoxification|
|cellular response to reactive oxygen species|
|heme binding|
|drug catabolic process|
|heparin binding|
|response to reactive oxygen species|
|response to mechanical stimulus|
|cellular response to toxic substance|
|cellular response to oxidative stress|
|lysosome|
|aging|
|response to lipopolysaccharide|
|response to molecule of bacterial origin|
|defense response to bacterium|
|extracellular structure organization|
|response to oxidative stress|
|chromatin binding|
|cofactor metabolic process|
|neutrophil degranulation|
|neutrophil activation involved in immune response|
|response to nutrient levels|
|neutrophil mediated immunity|
|drug metabolic process|
|neutrophil activation|
|granulocyte activation|
|response to toxic substance|
|leukocyte degranulation|
|myeloid leukocyte mediated immunity|
|myeloid cell activation involved in immune response|
|response to extracellular stimulus|
|response to inorganic substance|
|myeloid leukocyte activation|
|small molecule biosynthetic process|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|intracellular membrane-bounded organelle|
|response to bacterium|
|regulated exocytosis|
|leukocyte mediated immunity|
|exocytosis|
|response to lipid|
|negative regulation of apoptotic process|
|cellular homeostasis|
|negative regulation of programmed cell death|
|leukocyte activation|
|defense response to other organism|
|oxidation-reduction process|
|negative regulation of cell death|
|oxoacid metabolic process|
|secretion by cell|
|organic acid metabolic process|
|export from cell|
|cellular response to oxygen-containing compound|
|cell activation|
|immune effector process|
|secretion|
|response to abiotic stimulus|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|regulation of apoptotic process|
|response to oxygen-containing compound|
|regulation of programmed cell death|
|extracellular space|
|homeostatic process|
|regulation of cell death|
|cellular response to stress|
|small molecule metabolic process|
|cellular catabolic process|
|protein-containing complex subunit organization|
|immune response|
|extracellular region|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6510
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -1.43 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MPO Expression in NALM6 Cells: -1.43'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>