MPST [The Human Chemical-Genetic Interaction Map Project]

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======= MPST =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MPST
  * **<color #00a2e8>Official Name</color>**: mercaptopyruvate sulfurtransferase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4357|4357]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P25325|P25325]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MPST&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MPST|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602496|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Transfer of a sulfur ion to cyanide or to other thiol compounds. Also has weak rhodanese activity. Detoxifies cyanide and is required for thiosulfate biosynthesis. Acts as an antioxidant. In combination with cysteine aminotransferase (CAT), contributes to the catabolism of cysteine and is an important producer of hydrogen sulfide in the brain, retina and vascular endothelial cells. Hydrogen sulfide H(2)S is an important synaptic modulator, signaling molecule, smooth muscle contractor and neuroprotectant. Its production by the 3MST/CAT pathway is regulated by calcium ions (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Rhodanese|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|3-mercaptopyruvate sulfurtransferase activity|
|cyanate catabolic process|
|cyanate metabolic process|
|thiosulfate sulfurtransferase activity|
|hydrogen sulfide biosynthetic process|
|toxin biosynthetic process|
|homoserine metabolic process|
|transsulfuration|
|hydrogen sulfide metabolic process|
|cysteine metabolic process|
|homocysteine metabolic process|
|sulfur amino acid catabolic process|
|secondary metabolite biosynthetic process|
|toxin metabolic process|
|sulfur amino acid metabolic process|
|serine family amino acid metabolic process|
|sulfur compound catabolic process|
|secondary metabolic process|
|spinal cord development|
|liver development|
|cellular amino acid catabolic process|
|hepaticobiliary system development|
|sulfur compound biosynthetic process|
|alpha-amino acid metabolic process|
|organic acid catabolic process|
|carboxylic acid catabolic process|
|kidney development|
|synapse|
|renal system development|
|cellular amino acid metabolic process|
|urogenital system development|
|neuron projection|
|sulfur compound metabolic process|
|mitochondrial matrix|
|gland development|
|cellular nitrogen compound catabolic process|
|small molecule catabolic process|
|drug metabolic process|
|response to toxic substance|
|cell junction|
|carboxylic acid metabolic process|
|central nervous system development|
|oxoacid metabolic process|
|organic acid metabolic process|
|organonitrogen compound catabolic process|
|identical protein binding|
|mitochondrion|
|small molecule metabolic process|
|organic substance catabolic process|
|cellular catabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp114|A-196 10μM R03 exp114]]|-1.7|
|[[:results:exp312|2-Methoxyestradiol 0.55 to 1μM on day4 R07 exp312]]|1.76|
|[[:results:exp224|CB-839 10μM R05 exp224]]|1.94|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8906
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.11 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MPST Expression in NALM6 Cells: 6.11'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>