MPV17L2 [The Human Chemical-Genetic Interaction Map Project]

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======= MPV17L2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MPV17L2
  * **<color #00a2e8>Official Name</color>**: MPV17 mitochondrial inner membrane protein like 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=84769|84769]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q567V2|Q567V2]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MPV17L2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MPV17L2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/616133|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Required for the assembly and stability of the mitochondrial ribosome (PubMed:24948607). Is a positive regulator of mitochondrial protein synthesis (PubMed:24948607). {ECO:0000269|PubMed:24948607}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Mpv17 PMP22|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|mitochondrial ribosome assembly|
|positive regulation of mitochondrial translation|
|regulation of mitochondrial translation|
|regulation of mitochondrial gene expression|
|mitochondrial large ribosomal subunit|
|ribosome assembly|
|positive regulation of translation|
|positive regulation of cellular amide metabolic process|
|ribonucleoprotein complex assembly|
|ribonucleoprotein complex subunit organization|
|ribosome biogenesis|
|regulation of translation|
|mitochondrial inner membrane|
|regulation of cellular amide metabolic process|
|ribonucleoprotein complex biogenesis|
|posttranscriptional regulation of gene expression|
|organelle assembly|
|cellular protein-containing complex assembly|
|protein-containing complex assembly|
|positive regulation of cellular protein metabolic process|
|positive regulation of protein metabolic process|
|protein-containing complex subunit organization|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp198|Etoposide 0.1μM R05 exp198]]|1.7|
|[[:results:exp460|BML-284 0.09μM R08 exp460]]|1.72|
|[[:results:exp301|VER-155008 3.9μM R06 exp301]]|1.73|
|[[:results:exp334|All-trans-Retinoic-Acid 40μM R07 exp334]]|1.75|
|[[:results:exp433|LJH685 50μM R08 exp433]]|1.76|
|[[:results:exp129|Isonicotinamide 500μM R03 exp129]]|1.77|
|[[:results:exp160|Ribavirin 10 to 15μM on day4 R04 exp160]]|1.78|
|[[:results:exp78|Pterostilbene 16μM R02 exp78]]|1.8|
|[[:results:exp52|Ribavirin 10μM R01 exp52]]|1.8|
|[[:results:exp218|A-395 10μM R05 exp218]]|1.81|
|[[:results:exp15|Cycloheximide 0.2μM R00 exp15]]|1.81|
|[[:results:exp436|Dynasore 7μM R08 exp436]]|1.81|
|[[:results:exp390|Pifithrin-alpha 20μM R07 exp390]]|1.81|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|1.82|
|[[:results:exp162|BI-D1870 2μM R04 exp162]]|1.87|
|[[:results:exp68|Clomiphene 4.4μM R02 exp68]]|1.88|
|[[:results:exp310|2-Methoxyestradiol 0.55μM R07 exp310]]|1.89|
|[[:results:exp48|Mubritinib 0.2μM R01 exp48]]|1.94|
|[[:results:exp75|MK-1775 0.32μM R02 exp75]]|1.99|
|[[:results:exp189|Temozolomide 200μM R04 exp189]]|2.07|
|[[:results:exp131|L-74142 5μM R03 exp131]]|2.2|
|[[:results:exp30|Rapamycin 10μM R00 exp30]]|2.24|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|2.26|
|[[:results:exp360|Genistein 15μM R07 exp360]]|2.34|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|2.44|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:pde12|PDE12]]|0.555|
|[[:human genes:x:xpnpep3|XPNPEP3]]|0.543|
|[[:human genes:f:fastkd2|FASTKD2]]|0.52|
|[[:human genes:r:rmnd1|RMND1]]|0.501|
|[[:human genes:p:pet117|PET117]]|0.5|
|[[:human genes:s:sfxn4|SFXN4]]|0.493|
|[[:human genes:n:ndufb10|NDUFB10]]|0.49|
|[[:human genes:m:mrpl30|MRPL30]]|0.488|
|[[:human genes:n:nsun4|NSUN4]]|0.488|
|[[:human genes:n:nubpl|NUBPL]]|0.484|
|[[:human genes:p:prepl|PREPL]]|0.478|
|[[:human genes:c:clpx|CLPX]]|0.472|
|[[:human genes:c:ccdc90b|CCDC90B]]|0.465|
|[[:human genes:s:slc30a9|SLC30A9]]|0.464|
|[[:human genes:c:cox6a1|COX6A1]]|0.462|
|[[:human genes:m:mcur1|MCUR1]]|0.46|
|[[:human genes:t:tsfm|TSFM]]|0.457|
|[[:human genes:m:mtif2|MTIF2]]|0.452|
|[[:human genes:e:eral1|ERAL1]]|0.451|
|[[:human genes:c:cluh|CLUH]]|0.441|
|[[:human genes:n:ndufv2|NDUFV2]]|0.44|
|[[:human genes:g:grsf1|GRSF1]]|0.44|
|[[:human genes:c:cox8a|COX8A]]|0.437|
|[[:human genes:d:ddx28|DDX28]]|0.424|
|[[:human genes:m:mto1|MTO1]]|0.423|
|[[:human genes:p:ptcd3|PTCD3]]|0.422|
|[[:human genes:a:agpat5|AGPAT5]]|0.422|
|[[:human genes:c:clpp|CLPP]]|0.415|
|[[:human genes:a:acad9|ACAD9]]|0.415|
|[[:human genes:c:cox18|COX18]]|0.411|
|[[:human genes:c:chchd1|CHCHD1]]|0.409|
|[[:human genes:p:pet112|PET112]]|0.408|
|[[:human genes:m:mrpl49|MRPL49]]|0.406|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 592
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.2 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MPV17L2 Expression in NALM6 Cells: 4.2'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>