MR1 [The Human Chemical-Genetic Interaction Map Project]

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======= MR1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MR1
  * **<color #00a2e8>Official Name</color>**: major histocompatibility complex, class I-related
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3140|3140]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q95460|Q95460]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MR1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MR1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600764|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  MAIT (mucosal-associated invariant T-cells) lymphocytes represent a small population of T-cells primarily found in the gut. The protein encoded by this gene is an antigen-presenting molecule that presents metabolites of microbial vitamin B to MAITs. This presentation may activate the MAITs to regulate the amounts of specific types of bacteria in the gut. Several transcript variants encoding different isoforms have been found for this gene, and a pseudogene of it has been detected about 36 kbp upstream on the same chromosome. [provided by RefSeq, Jul 2015]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|MHC I|
|C1-set|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|interleukin-17 production|
|MHC class I receptor activity|
|MHC class I protein complex|
|interleukin-1 beta production|
|interleukin-1 production|
|cytokine production involved in immune response|
|defense response to Gram-negative bacterium|
|antigen processing and presentation of peptide antigen via MHC class I|
|cytokine production|
|production of molecular mediator of immune response|
|antigen processing and presentation of peptide antigen|
|antigen processing and presentation|
|defense response to bacterium|
|external side of plasma membrane|
|response to bacterium|
|innate immune response|
|endoplasmic reticulum membrane|
|defense response to other organism|
|endoplasmic reticulum|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|extracellular space|
|immune response|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp199|Etoposide 0.3μM R05 exp199]]|-2.12|
|[[:results:exp180|Dynasore 10μM R04 exp180]]|1.7|
|[[:results:exp519|RS-1 10μM R08 exp519]]|1.74|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 14021
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.65 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MR1 Expression in NALM6 Cells: 5.65'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>