MRI1 [The Human Chemical-Genetic Interaction Map Project]

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======= MRI1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MRI1
  * **<color #00a2e8>Official Name</color>**: methylthioribose-1-phosphate isomerase 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=84245|84245]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9BV20|Q9BV20]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MRI1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MRI1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/615105|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This enzyme functions in the methionine salvage pathway by catalyzing the interconversion of methylthioribose-1-phosphate and methythioribulose-1-phosphate. Elevated expression of the encoded protein is associated with metastatic melanoma and this protein promotes melanoma cell invasion independent of its enzymatic activity. Mutations in this gene may be associated with vanishing white matter disease (VMWD). [provided by RefSeq, Jul 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P). Independently from catalytic activity, promotes cell invasion in response to constitutive RhoA activation by promoting FAK tyrosine phosphorylation and stress fiber turnover. {ECO:0000255|HAMAP-Rule:MF_03119, ECO:0000269|PubMed:19620624}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|IF-2B|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|S-methyl-5-thioribose-1-phosphate isomerase activity|
|L-methionine salvage from S-adenosylmethionine|
|L-methionine salvage from methylthioadenosine|
|S-adenosylmethionine cycle|
|L-methionine salvage|
|L-methionine biosynthetic process|
|amino acid salvage|
|methionine biosynthetic process|
|methionine metabolic process|
|S-adenosylmethionine metabolic process|
|sulfur amino acid biosynthetic process|
|aspartate family amino acid biosynthetic process|
|cellular metabolic compound salvage|
|sulfur amino acid metabolic process|
|aspartate family amino acid metabolic process|
|alpha-amino acid biosynthetic process|
|cellular amino acid biosynthetic process|
|cell projection|
|fibrillar center|
|sulfur compound biosynthetic process|
|cellular modified amino acid metabolic process|
|alpha-amino acid metabolic process|
|coenzyme metabolic process|
|carboxylic acid biosynthetic process|
|organic acid biosynthetic process|
|cellular amino acid metabolic process|
|sulfur compound metabolic process|
|cofactor metabolic process|
|drug metabolic process|
|small molecule biosynthetic process|
|carboxylic acid metabolic process|
|oxoacid metabolic process|
|organic acid metabolic process|
|identical protein binding|
|organonitrogen compound biosynthetic process|
|small molecule metabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp272|CHIR-124 0.04μM R06 exp272]]|-2.51|
|[[:results:exp67|BVD-523 15μM R02 exp67]]|-2.12|
|[[:results:exp152|SGC2043 10μM R03 exp152]]|-1.88|
|[[:results:exp23|Nocodazole 0.02μM R00 exp23]]|-1.85|
|[[:results:exp225|Celastrol 0.12μM R05 exp225]]|-1.74|
|[[:results:exp350|Deferoxamine 11μM R07 exp350]]|2.18|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4503
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.98 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MRI1 Expression in NALM6 Cells: 5.98'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>