MRPL12 [The Human Chemical-Genetic Interaction Map Project]

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======= MRPL12 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MRPL12
  * **<color #00a2e8>Official Name</color>**: mitochondrial ribosomal protein L12
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6182|6182]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P52815|P52815]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MRPL12&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MRPL12|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602375|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Associates with mitochondrial RNA polymerase to activate transcription. {ECO:0000269|PubMed:22003127}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Ribosomal L12|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|mitochondrial transcription|
|mitochondrial RNA metabolic process|
|mitochondrial large ribosomal subunit|
|mitochondrial translational elongation|
|mitochondrial translational termination|
|translational termination|
|mitochondrial translation|
|translational elongation|
|cellular protein complex disassembly|
|mitochondrial gene expression|
|structural constituent of ribosome|
|protein-containing complex disassembly|
|translation|
|mitochondrial inner membrane|
|cellular component disassembly|
|peptide biosynthetic process|
|amide biosynthetic process|
|peptide metabolic process|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|RNA biosynthetic process|
|cellular amide metabolic process|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|mitochondrion|
|organic cyclic compound biosynthetic process|
|RNA binding|
|organonitrogen compound biosynthetic process|
|positive regulation of transcription, DNA-templated|
|cellular nitrogen compound biosynthetic process|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|positive regulation of RNA metabolic process|
|macromolecule biosynthetic process|
|protein-containing complex subunit organization|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp170|Metformin 100 to 150μM on day4 R04 exp170]]|-1.89|
|[[:results:exp294|Nutlin-3A 1.6μM R06 exp294]]|1.75|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|1.9|
|[[:results:exp454|Bafilomycin-A1 0.009μM R08 exp454]]|1.92|
|[[:results:exp360|Genistein 15μM R07 exp360]]|1.95|
|[[:results:exp492|iCRT14 30μM R08 exp492]]|1.96|
|[[:results:exp474|CR131-b 0.005μM R08 exp474]]|1.98|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|2.33|
|[[:results:exp441|GSK-J4 1.5μM R08 exp441]]|2.37|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:m:mrps5|MRPS5]]|0.667|
|[[:human genes:y:yars2|YARS2]]|0.644|
|[[:human genes:t:tars2|TARS2]]|0.638|
|[[:human genes:n:nars2|NARS2]]|0.626|
|[[:human genes:m:mrpl53|MRPL53]]|0.611|
|[[:human genes:m:mrpl21|MRPL21]]|0.605|
|[[:human genes:r:rpusd4|RPUSD4]]|0.602|
|[[:human genes:s:selrc1|SELRC1]]|0.601|
|[[:human genes:h:hsd17b10|HSD17B10]]|0.6|
|[[:human genes:m:mrps21|MRPS21]]|0.598|
|[[:human genes:m:mrpl23|MRPL23]]|0.594|
|[[:human genes:g:gfm1|GFM1]]|0.592|
|[[:human genes:d:dap3|DAP3]]|0.591|
|[[:human genes:m:mrp63|MRP63]]|0.588|
|[[:human genes:m:mrps18a|MRPS18A]]|0.585|
|[[:human genes:t:tefm|TEFM]]|0.585|
|[[:human genes:m:mrps14|MRPS14]]|0.584|
|[[:human genes:v:vars2|VARS2]]|0.581|
|[[:human genes:p:pars2|PARS2]]|0.578|
|[[:human genes:m:mrpl3|MRPL3]]|0.576|
|[[:human genes:f:ftsj2|FTSJ2]]|0.575|
|[[:human genes:m:mrps34|MRPS34]]|0.573|
|[[:human genes:m:mrps6|MRPS6]]|0.571|
|[[:human genes:r:rnaseh1|RNASEH1]]|0.565|
|[[:human genes:f:fastkd5|FASTKD5]]|0.561|
|[[:human genes:q:qrsl1|QRSL1]]|0.557|
|[[:human genes:r:rbfa|RBFA]]|0.555|
|[[:human genes:g:gtpbp10|GTPBP10]]|0.553|
|[[:human genes:g:gatc|GATC]]|0.553|
|[[:human genes:s:sars2|SARS2]]|0.549|
|[[:human genes:m:mrps16|MRPS16]]|0.549|
|[[:human genes:e:ears2|EARS2]]|0.548|
|[[:human genes:m:mrps9|MRPS9]]|0.546|
|[[:human genes:n:ndufb11|NDUFB11]]|0.545|
|[[:human genes:m:mrps10|MRPS10]]|0.538|
|[[:human genes:m:mrpl45|MRPL45]]|0.535|
|[[:human genes:m:mrps35|MRPS35]]|0.533|
|[[:human genes:s:sco2|SCO2]]|0.533|
|[[:human genes:l:lars2|LARS2]]|0.53|
|[[:human genes:m:mrpl47|MRPL47]]|0.53|
|[[:human genes:m:mrps2|MRPS2]]|0.527|
|[[:human genes:n:ndufa3|NDUFA3]]|0.525|
|[[:human genes:p:pet112|PET112]]|0.522|
|[[:human genes:m:mtg1|MTG1]]|0.521|
|[[:human genes:m:mtg2|MTG2]]|0.52|
|[[:human genes:m:mrps24|MRPS24]]|0.519|
|[[:human genes:m:mrps26|MRPS26]]|0.518|
|[[:human genes:m:mtpap|MTPAP]]|0.515|
|[[:human genes:w:wbscr16|WBSCR16]]|0.514|
|[[:human genes:r:rars2|RARS2]]|0.514|
|[[:human genes:m:mrpl55|MRPL55]]|0.514|
|[[:human genes:k:kiaa0391|KIAA0391]]|0.51|
|[[:human genes:s:supv3l1|SUPV3L1]]|0.51|
|[[:human genes:m:mars2|MARS2]]|0.509|
|[[:human genes:p:polg2|POLG2]]|0.509|
|[[:human genes:g:gfm2|GFM2]]|0.506|
|[[:human genes:m:mrps7|MRPS7]]|0.506|
|[[:human genes:p:pdss1|PDSS1]]|0.505|
|[[:human genes:d:dars2|DARS2]]|0.505|
|[[:human genes:b:bcs1l|BCS1L]]|0.503|
|[[:human genes:m:mrps25|MRPS25]]|0.499|
|[[:human genes:c:cox16|COX16]]|0.497|
|[[:human genes:c:coa3|COA3]]|0.497|
|[[:human genes:m:mipep|MIPEP]]|0.494|
|[[:human genes:h:hars2|HARS2]]|0.491|
|[[:human genes:c:c12orf65|C12orf65]]|0.489|
|[[:human genes:n:ndufaf7|NDUFAF7]]|0.484|
|[[:human genes:d:dhx30|DHX30]]|0.484|
|[[:human genes:a:aars2|AARS2]]|0.484|
|[[:human genes:h:hmgxb3|HMGXB3]]|0.483|
|[[:human genes:c:c10orf2|C10orf2]]|0.483|
|[[:human genes:m:mrpl42|MRPL42]]|0.483|
|[[:human genes:p:pnpt1|PNPT1]]|0.482|
|[[:human genes:t:trub2|TRUB2]]|0.481|
|[[:human genes:p:polg|POLG]]|0.48|
|[[:human genes:f:fars2|FARS2]]|0.48|
|[[:human genes:i:iba57|IBA57]]|0.477|
|[[:human genes:c:c17orf89|C17orf89]]|0.474|
|[[:human genes:t:tufm|TUFM]]|0.47|
|[[:human genes:c:coq2|COQ2]]|0.468|
|[[:human genes:m:mterfd2|MTERFD2]]|0.468|
|[[:human genes:g:gtpbp6|GTPBP6]]|0.468|
|[[:human genes:n:ndufb5|NDUFB5]]|0.467|
|[[:human genes:m:mrpl15|MRPL15]]|0.466|
|[[:human genes:t:tmem242|TMEM242]]|0.465|
|[[:human genes:m:mettl17|METTL17]]|0.462|
|[[:human genes:m:mrps12|MRPS12]]|0.462|
|[[:human genes:t:tfam|TFAM]]|0.462|
|[[:human genes:m:mrpl2|MRPL2]]|0.461|
|[[:human genes:m:mrpl20|MRPL20]]|0.461|
|[[:human genes:m:mrpl43|MRPL43]]|0.46|
|[[:human genes:u:uqcr10|UQCR10]]|0.458|
|[[:human genes:m:mrpl38|MRPL38]]|0.458|
|[[:human genes:n:ndufa2|NDUFA2]]|0.457|
|[[:human genes:n:ndufs7|NDUFS7]]|0.456|
|[[:human genes:n:ndufc2|NDUFC2]]|0.456|
|[[:human genes:m:mrpl36|MRPL36]]|0.453|
|[[:human genes:e:elac2|ELAC2]]|0.452|
|[[:human genes:t:timm8b|TIMM8B]]|0.452|
|[[:human genes:p:polrmt|POLRMT]]|0.451|
|[[:human genes:m:mrps22|MRPS22]]|0.451|
|[[:human genes:c:coa6|COA6]]|0.45|
|[[:human genes:s:slc25a26|SLC25A26]]|0.45|
|[[:human genes:t:tomm20|TOMM20]]|0.448|
|[[:human genes:f:foxred1|FOXRED1]]|0.446|
|[[:human genes:c:cox6c|COX6C]]|0.445|
|[[:human genes:m:mrpl18|MRPL18]]|0.443|
|[[:human genes:m:mrpl41|MRPL41]]|0.44|
|[[:human genes:c:coq7|COQ7]]|0.438|
|[[:human genes:m:mrpl33|MRPL33]]|0.438|
|[[:human genes:a:atp5sl|ATP5SL]]|0.438|
|[[:human genes:m:mrpl46|MRPL46]]|0.438|
|[[:human genes:c:cox11|COX11]]|0.437|
|[[:human genes:g:grsf1|GRSF1]]|0.437|
|[[:human genes:n:ndufb6|NDUFB6]]|0.436|
|[[:human genes:n:ndufs2|NDUFS2]]|0.436|
|[[:human genes:m:mrpl13|MRPL13]]|0.435|
|[[:human genes:m:mrps33|MRPS33]]|0.435|
|[[:human genes:n:ndufa1|NDUFA1]]|0.433|
|[[:human genes:m:mrpl4|MRPL4]]|0.432|
|[[:human genes:m:mtrf1l|MTRF1L]]|0.431|
|[[:human genes:c:cox7b|COX7B]]|0.429|
|[[:human genes:m:mrpl34|MRPL34]]|0.429|
|[[:human genes:n:ndufa11|NDUFA11]]|0.426|
|[[:human genes:r:rpusd3|RPUSD3]]|0.425|
|[[:human genes:e:ecsit|ECSIT]]|0.425|
|[[:human genes:m:mrpl11|MRPL11]]|0.423|
|[[:human genes:t:tomm40|TOMM40]]|0.423|
|[[:human genes:s:ssbp1|SSBP1]]|0.423|
|[[:human genes:c:chchd1|CHCHD1]]|0.421|
|[[:human genes:a:acad9|ACAD9]]|0.421|
|[[:human genes:c:coq3|COQ3]]|0.421|
|[[:human genes:n:ndufaf5|NDUFAF5]]|0.42|
|[[:human genes:d:ddx28|DDX28]]|0.417|
|[[:human genes:f:fastkd2|FASTKD2]]|0.416|
|[[:human genes:n:ndufb3|NDUFB3]]|0.415|
|[[:human genes:c:chchd4|CHCHD4]]|0.415|
|[[:human genes:m:mrps17|MRPS17]]|0.413|
|[[:human genes:m:mrpl44|MRPL44]]|0.413|
|[[:human genes:a:atp5d|ATP5D]]|0.411|
|[[:human genes:m:mrpl17|MRPL17]]|0.411|
|[[:human genes:a:atp5c1|ATP5C1]]|0.409|
|[[:human genes:w:wars2|WARS2]]|0.409|
|[[:human genes:n:ndufaf3|NDUFAF3]]|0.408|
|[[:human genes:e:eral1|ERAL1]]|0.406|
|[[:human genes:n:ndufa8|NDUFA8]]|0.406|
|[[:human genes:m:mtif3|MTIF3]]|0.406|
|[[:human genes:c:cars2|CARS2]]|0.405|
|[[:human genes:c:cox5a|COX5A]]|0.404|
|[[:human genes:a:aifm1|AIFM1]]|0.404|
|[[:human genes:m:mrpl37|MRPL37]]|0.403|
|[[:human genes:m:mrps27|MRPS27]]|0.403|
|[[:human genes:d:dhrsx|DHRSX]]|0.403|
|[[:human genes:m:mrps23|MRPS23]]|0.402|
|[[:human genes:m:mrpl22|MRPL22]]|0.402|
|[[:human genes:p:pgm3|PGM3]]|0.402|
|[[:human genes:m:mtif2|MTIF2]]|0.401|
|[[:human genes:p:pet117|PET117]]|0.401|
|[[:human genes:p:ptcd1|PTCD1]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 182/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|5/28|
|blood|6/28|
|bone|7/26|
|breast|14/33|
|central nervous system|8/56|
|cervix|3/4|
|colorectal|6/17|
|esophagus|5/13|
|fibroblast|0/1|
|gastric|5/16|
|kidney|4/21|
|liver|6/20|
|lung|22/75|
|lymphocyte|3/16|
|ovary|1/26|
|pancreas|5/24|
|peripheral nervous system|0/16|
|plasma cell|3/15|
|prostate|0/1|
|skin|4/24|
|soft tissue|4/9|
|thyroid|0/2|
|upper aerodigestive|5/22|
|urinary tract|6/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1270
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.46 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MRPL12 Expression in NALM6 Cells: 5.46'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>