MRPL17 [The Human Chemical-Genetic Interaction Map Project]

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======= MRPL17 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MRPL17
  * **<color #00a2e8>Official Name</color>**: mitochondrial ribosomal protein L17
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=63875|63875]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9NRX2|Q9NRX2]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MRPL17&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MRPL17|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/611830|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Ribosomal L17|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|mitochondrial large ribosomal subunit|
|mitochondrial translational elongation|
|mitochondrial translational termination|
|translational termination|
|mitochondrial translation|
|translational elongation|
|cellular protein complex disassembly|
|mitochondrial gene expression|
|structural constituent of ribosome|
|protein-containing complex disassembly|
|protein domain specific binding|
|translation|
|mitochondrial inner membrane|
|cellular component disassembly|
|peptide biosynthetic process|
|amide biosynthetic process|
|peptide metabolic process|
|cellular amide metabolic process|
|mitochondrion|
|organonitrogen compound biosynthetic process|
|cellular nitrogen compound biosynthetic process|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|protein-containing complex subunit organization|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp438|NN-Diethyl-meta-toluamide 500μM R08 exp438]]|-1.98|
|[[:results:exp214|2-Deoxy-D-glucose 800μM R05 exp214]]|-1.88|
|[[:results:exp441|GSK-J4 1.5μM R08 exp441]]|1.73|
|[[:results:exp89|Vemurafenib 6.6μM R02 exp89]]|1.73|
|[[:results:exp534|Trientine 500μM R08 exp534]]|1.76|
|[[:results:exp212|Phenformin 20μM R05 exp212]]|1.86|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|1.89|
|[[:results:exp75|MK-1775 0.32μM R02 exp75]]|1.95|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|2.38|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|2.59|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:pet117|PET117]]|0.536|
|[[:human genes:m:mettl17|METTL17]]|0.523|
|[[:human genes:m:mrps25|MRPS25]]|0.516|
|[[:human genes:m:mrps26|MRPS26]]|0.516|
|[[:human genes:m:mrps27|MRPS27]]|0.515|
|[[:human genes:c:coa3|COA3]]|0.515|
|[[:human genes:m:mrps21|MRPS21]]|0.514|
|[[:human genes:n:ndufb11|NDUFB11]]|0.513|
|[[:human genes:f:ftsj2|FTSJ2]]|0.507|
|[[:human genes:m:mrpl53|MRPL53]]|0.504|
|[[:human genes:m:mrpl44|MRPL44]]|0.503|
|[[:human genes:q:qrsl1|QRSL1]]|0.503|
|[[:human genes:h:hsd17b10|HSD17B10]]|0.503|
|[[:human genes:d:dars2|DARS2]]|0.502|
|[[:human genes:p:pet112|PET112]]|0.494|
|[[:human genes:m:mrps12|MRPS12]]|0.493|
|[[:human genes:p:ptcd3|PTCD3]]|0.493|
|[[:human genes:m:mrps34|MRPS34]]|0.492|
|[[:human genes:d:ddx28|DDX28]]|0.49|
|[[:human genes:r:rars2|RARS2]]|0.484|
|[[:human genes:n:nars2|NARS2]]|0.483|
|[[:human genes:r:rpusd3|RPUSD3]]|0.48|
|[[:human genes:m:mrpl23|MRPL23]]|0.474|
|[[:human genes:m:mrps16|MRPS16]]|0.474|
|[[:human genes:m:mrpl42|MRPL42]]|0.468|
|[[:human genes:m:mrpl45|MRPL45]]|0.468|
|[[:human genes:e:eral1|ERAL1]]|0.467|
|[[:human genes:m:mrp63|MRP63]]|0.466|
|[[:human genes:c:cars2|CARS2]]|0.466|
|[[:human genes:a:aars2|AARS2]]|0.465|
|[[:human genes:p:pars2|PARS2]]|0.464|
|[[:human genes:t:tfb1m|TFB1M]]|0.463|
|[[:human genes:m:mrps24|MRPS24]]|0.463|
|[[:human genes:m:mrps5|MRPS5]]|0.462|
|[[:human genes:r:rnmtl1|RNMTL1]]|0.462|
|[[:human genes:c:cox7b|COX7B]]|0.461|
|[[:human genes:n:ndufb10|NDUFB10]]|0.461|
|[[:human genes:a:aifm1|AIFM1]]|0.46|
|[[:human genes:m:mrpl37|MRPL37]]|0.459|
|[[:human genes:y:yars2|YARS2]]|0.455|
|[[:human genes:n:ndufa1|NDUFA1]]|0.453|
|[[:human genes:n:ndufa2|NDUFA2]]|0.452|
|[[:human genes:p:polrmt|POLRMT]]|0.451|
|[[:human genes:m:mrpl3|MRPL3]]|0.45|
|[[:human genes:v:vars2|VARS2]]|0.449|
|[[:human genes:n:ndufc2|NDUFC2]]|0.448|
|[[:human genes:e:ears2|EARS2]]|0.448|
|[[:human genes:m:mrps7|MRPS7]]|0.448|
|[[:human genes:m:mrpl18|MRPL18]]|0.447|
|[[:human genes:t:tars2|TARS2]]|0.446|
|[[:human genes:t:trub2|TRUB2]]|0.446|
|[[:human genes:g:grsf1|GRSF1]]|0.445|
|[[:human genes:n:ndufb4|NDUFB4]]|0.445|
|[[:human genes:d:dap3|DAP3]]|0.445|
|[[:human genes:m:mrps6|MRPS6]]|0.444|
|[[:human genes:m:mrps35|MRPS35]]|0.444|
|[[:human genes:g:gfm1|GFM1]]|0.443|
|[[:human genes:m:mrpl47|MRPL47]]|0.442|
|[[:human genes:n:ndufa11|NDUFA11]]|0.441|
|[[:human genes:m:mrpl20|MRPL20]]|0.44|
|[[:human genes:a:acad9|ACAD9]]|0.44|
|[[:human genes:n:ndufb9|NDUFB9]]|0.44|
|[[:human genes:m:mrpl43|MRPL43]]|0.438|
|[[:human genes:m:mrps18a|MRPS18A]]|0.438|
|[[:human genes:t:tefm|TEFM]]|0.435|
|[[:human genes:m:mrps9|MRPS9]]|0.435|
|[[:human genes:h:hars2|HARS2]]|0.434|
|[[:human genes:p:pnpt1|PNPT1]]|0.433|
|[[:human genes:g:gfm2|GFM2]]|0.432|
|[[:human genes:c:chchd1|CHCHD1]]|0.431|
|[[:human genes:s:selrc1|SELRC1]]|0.431|
|[[:human genes:m:mrps14|MRPS14]]|0.431|
|[[:human genes:m:malsu1|MALSU1]]|0.43|
|[[:human genes:m:mrpl11|MRPL11]]|0.43|
|[[:human genes:f:fastkd2|FASTKD2]]|0.429|
|[[:human genes:n:ndufa3|NDUFA3]]|0.429|
|[[:human genes:m:mars2|MARS2]]|0.429|
|[[:human genes:m:mrpl39|MRPL39]]|0.428|
|[[:human genes:m:mrpl35|MRPL35]]|0.428|
|[[:human genes:m:mrpl55|MRPL55]]|0.423|
|[[:human genes:f:fars2|FARS2]]|0.421|
|[[:human genes:l:lars2|LARS2]]|0.421|
|[[:human genes:m:mrps22|MRPS22]]|0.418|
|[[:human genes:m:mrpl49|MRPL49]]|0.418|
|[[:human genes:h:hmgxb3|HMGXB3]]|0.416|
|[[:human genes:m:mrpl21|MRPL21]]|0.416|
|[[:human genes:c:c12orf65|C12orf65]]|0.416|
|[[:human genes:w:wars2|WARS2]]|0.415|
|[[:human genes:n:ndufa6|NDUFA6]]|0.415|
|[[:human genes:r:rpusd4|RPUSD4]]|0.415|
|[[:human genes:n:nsun4|NSUN4]]|0.413|
|[[:human genes:m:mrpl12|MRPL12]]|0.411|
|[[:human genes:t:tmem261|TMEM261]]|0.411|
|[[:human genes:t:tfb2m|TFB2M]]|0.41|
|[[:human genes:r:rbfa|RBFA]]|0.41|
|[[:human genes:n:ndufv2|NDUFV2]]|0.409|
|[[:human genes:w:wbscr16|WBSCR16]]|0.409|
|[[:human genes:c:coa6|COA6]]|0.408|
|[[:human genes:a:atp5sl|ATP5SL]]|0.408|
|[[:human genes:m:mrpl28|MRPL28]]|0.407|
|[[:human genes:g:gtpbp10|GTPBP10]]|0.407|
|[[:human genes:g:gtpbp8|GTPBP8]]|0.406|
|[[:human genes:n:ndufb6|NDUFB6]]|0.406|
|[[:human genes:k:kiaa0391|KIAA0391]]|0.404|
|[[:human genes:s:sco2|SCO2]]|0.403|
|[[:human genes:t:tfam|TFAM]]|0.402|
|[[:human genes:s:supv3l1|SUPV3L1]]|0.402|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 47/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|2/28|
|blood|1/28|
|bone|1/26|
|breast|3/33|
|central nervous system|0/56|
|cervix|1/4|
|colorectal|2/17|
|esophagus|2/13|
|fibroblast|0/1|
|gastric|2/16|
|kidney|1/21|
|liver|2/20|
|lung|5/75|
|lymphocyte|2/16|
|ovary|0/26|
|pancreas|1/24|
|peripheral nervous system|2/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|3/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|2/22|
|urinary tract|5/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 477
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.37 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MRPL17 Expression in NALM6 Cells: 5.37'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>