MRPL27 [The Human Chemical-Genetic Interaction Map Project]

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======= MRPL27 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MRPL27
  * **<color #00a2e8>Official Name</color>**: mitochondrial ribosomal protein L27
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=51264|51264]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9P0M9|Q9P0M9]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MRPL27&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MRPL27|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/611837|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Ribosomal L27|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|mitochondrial large ribosomal subunit|
|mitochondrial translational elongation|
|mitochondrial translational termination|
|translational termination|
|mitochondrial translation|
|translational elongation|
|cellular protein complex disassembly|
|mitochondrial gene expression|
|structural constituent of ribosome|
|protein-containing complex disassembly|
|translation|
|mitochondrial inner membrane|
|cellular component disassembly|
|peptide biosynthetic process|
|amide biosynthetic process|
|peptide metabolic process|
|cellular amide metabolic process|
|mitochondrion|
|RNA binding|
|organonitrogen compound biosynthetic process|
|cellular nitrogen compound biosynthetic process|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|protein-containing complex subunit organization|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp392|PT-1 25μM R07 exp392]]|-2.08|
|[[:results:exp526|Sulforaphane 9μM R08 exp526 no dilution day6]]|-1.75|
|[[:results:exp356|Docosahexaenoic-acid 50μM R07 exp356]]|-1.74|
|[[:results:exp461|BS-181 20μM R08 exp461]]|-1.73|
|[[:results:exp441|GSK-J4 1.5μM R08 exp441]]|2|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:m:mrpl21|MRPL21]]|0.531|
|[[:human genes:h:hsd17b10|HSD17B10]]|0.526|
|[[:human genes:m:mrps14|MRPS14]]|0.522|
|[[:human genes:c:cox16|COX16]]|0.505|
|[[:human genes:s:sars2|SARS2]]|0.496|
|[[:human genes:e:elac2|ELAC2]]|0.495|
|[[:human genes:d:dap3|DAP3]]|0.495|
|[[:human genes:m:mrps16|MRPS16]]|0.495|
|[[:human genes:s:selrc1|SELRC1]]|0.495|
|[[:human genes:m:mrp63|MRP63]]|0.488|
|[[:human genes:s:slc25a26|SLC25A26]]|0.483|
|[[:human genes:y:yars2|YARS2]]|0.474|
|[[:human genes:m:mrpl23|MRPL23]]|0.468|
|[[:human genes:s:supv3l1|SUPV3L1]]|0.466|
|[[:human genes:m:mrps6|MRPS6]]|0.465|
|[[:human genes:b:bcs1l|BCS1L]]|0.464|
|[[:human genes:a:aasdhppt|AASDHPPT]]|0.459|
|[[:human genes:m:mrps21|MRPS21]]|0.458|
|[[:human genes:f:fars2|FARS2]]|0.458|
|[[:human genes:r:rpusd4|RPUSD4]]|0.454|
|[[:human genes:m:mrps5|MRPS5]]|0.451|
|[[:human genes:m:mrpl15|MRPL15]]|0.45|
|[[:human genes:s:slc25a19|SLC25A19]]|0.449|
|[[:human genes:s:sco2|SCO2]]|0.446|
|[[:human genes:m:mrps2|MRPS2]]|0.445|
|[[:human genes:h:hars2|HARS2]]|0.444|
|[[:human genes:t:tufm|TUFM]]|0.443|
|[[:human genes:m:mrps18a|MRPS18A]]|0.437|
|[[:human genes:n:ndufb5|NDUFB5]]|0.436|
|[[:human genes:t:triap1|TRIAP1]]|0.436|
|[[:human genes:u:uqcrc2|UQCRC2]]|0.436|
|[[:human genes:d:dars2|DARS2]]|0.433|
|[[:human genes:a:atxn10|ATXN10]]|0.432|
|[[:human genes:q:qrsl1|QRSL1]]|0.431|
|[[:human genes:m:mrps9|MRPS9]]|0.428|
|[[:human genes:c:cox6b1|COX6B1]]|0.427|
|[[:human genes:m:mrps26|MRPS26]]|0.427|
|[[:human genes:m:mrps25|MRPS25]]|0.426|
|[[:human genes:r:rnaseh1|RNASEH1]]|0.426|
|[[:human genes:t:tpk1|TPK1]]|0.424|
|[[:human genes:c:coa6|COA6]]|0.42|
|[[:human genes:a:atic|ATIC]]|0.42|
|[[:human genes:n:ndufa3|NDUFA3]]|0.419|
|[[:human genes:t:tfam|TFAM]]|0.418|
|[[:human genes:r:rbfa|RBFA]]|0.416|
|[[:human genes:p:pdss1|PDSS1]]|0.416|
|[[:human genes:z:zrsr2|ZRSR2]]|0.415|
|[[:human genes:k:kiaa0391|KIAA0391]]|0.415|
|[[:human genes:m:mrps34|MRPS34]]|0.414|
|[[:human genes:n:nars2|NARS2]]|0.412|
|[[:human genes:m:mrpl53|MRPL53]]|0.41|
|[[:human genes:m:mrpl47|MRPL47]]|0.408|
|[[:human genes:t:tomm22|TOMM22]]|0.408|
|[[:human genes:p:ppa2|PPA2]]|0.408|
|[[:human genes:c:cox17|COX17]]|0.406|
|[[:human genes:v:vars2|VARS2]]|0.405|
|[[:human genes:w:wbscr16|WBSCR16]]|0.405|
|[[:human genes:t:tars2|TARS2]]|0.404|
|[[:human genes:m:mars2|MARS2]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 158/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|4/28|
|blood|4/28|
|bone|5/26|
|breast|9/33|
|central nervous system|9/56|
|cervix|1/4|
|colorectal|7/17|
|esophagus|6/13|
|fibroblast|0/1|
|gastric|5/16|
|kidney|1/21|
|liver|10/20|
|lung|11/75|
|lymphocyte|4/16|
|ovary|3/26|
|pancreas|1/24|
|peripheral nervous system|1/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|3/24|
|soft tissue|2/9|
|thyroid|1/2|
|upper aerodigestive|5/22|
|urinary tract|7/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2905
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.98 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MRPL27 Expression in NALM6 Cells: 4.98'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>