MRPL32 [The Human Chemical-Genetic Interaction Map Project]

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======= MRPL32 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MRPL32
  * **<color #00a2e8>Official Name</color>**: mitochondrial ribosomal protein L32
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=64983|64983]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9BYC8|Q9BYC8]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MRPL32&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MRPL32|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/611839|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Ribosomal L32p|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|mitochondrial ribosome|
|mitochondrial large ribosomal subunit|
|mitochondrial translational elongation|
|mitochondrial translational termination|
|translational termination|
|mitochondrial translation|
|translational elongation|
|cellular protein complex disassembly|
|mitochondrial gene expression|
|structural constituent of ribosome|
|protein-containing complex disassembly|
|translation|
|mitochondrial inner membrane|
|cellular component disassembly|
|peptide biosynthetic process|
|amide biosynthetic process|
|peptide metabolic process|
|cellular amide metabolic process|
|mitochondrion|
|RNA binding|
|organonitrogen compound biosynthetic process|
|cellular nitrogen compound biosynthetic process|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|protein-containing complex subunit organization|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp531|THZ1 0.06μM R08 exp531]]|1.75|
|[[:results:exp111|R-DABN 8μM R03 exp111]]|1.77|
|[[:results:exp532|TIC10 10μM R08 exp532]]|1.78|
|[[:results:exp469|CFI-400945 25μM R08 exp469]]|1.97|
|[[:results:exp229|Dimethyloxaloylglycine 100μM R05 exp229]]|2.12|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:m:mrpl15|MRPL15]]|0.473|
|[[:human genes:d:dars2|DARS2]]|0.464|
|[[:human genes:m:mrp63|MRP63]]|0.461|
|[[:human genes:m:mrps24|MRPS24]]|0.461|
|[[:human genes:m:mrps26|MRPS26]]|0.457|
|[[:human genes:t:tars2|TARS2]]|0.455|
|[[:human genes:f:fars2|FARS2]]|0.45|
|[[:human genes:g:gfm1|GFM1]]|0.449|
|[[:human genes:m:mrps25|MRPS25]]|0.448|
|[[:human genes:s:sars2|SARS2]]|0.44|
|[[:human genes:h:hsd17b10|HSD17B10]]|0.437|
|[[:human genes:m:mrps14|MRPS14]]|0.436|
|[[:human genes:m:mrps16|MRPS16]]|0.431|
|[[:human genes:m:mrps18a|MRPS18A]]|0.429|
|[[:human genes:m:mrpl21|MRPL21]]|0.429|
|[[:human genes:c:cox7b|COX7B]]|0.429|
|[[:human genes:m:mtg2|MTG2]]|0.426|
|[[:human genes:s:supv3l1|SUPV3L1]]|0.426|
|[[:human genes:m:mrps2|MRPS2]]|0.425|
|[[:human genes:c:coa3|COA3]]|0.423|
|[[:human genes:v:vars2|VARS2]]|0.423|
|[[:human genes:m:mrps6|MRPS6]]|0.417|
|[[:human genes:r:rnaseh1|RNASEH1]]|0.416|
|[[:human genes:m:mrpl38|MRPL38]]|0.415|
|[[:human genes:n:nars2|NARS2]]|0.414|
|[[:human genes:m:mrpl23|MRPL23]]|0.413|
|[[:human genes:d:dap3|DAP3]]|0.412|
|[[:human genes:e:elac2|ELAC2]]|0.411|
|[[:human genes:t:tufm|TUFM]]|0.409|
|[[:human genes:m:mrpl53|MRPL53]]|0.406|
|[[:human genes:m:mrpl3|MRPL3]]|0.405|
|[[:human genes:c:c10orf2|C10orf2]]|0.404|
|[[:human genes:c:cox16|COX16]]|0.404|
|[[:human genes:m:mrps5|MRPS5]]|0.404|
|[[:human genes:r:rars2|RARS2]]|0.401|
|[[:human genes:n:ndufa3|NDUFA3]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 36/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|2/28|
|bone|1/26|
|breast|3/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|1/17|
|esophagus|1/13|
|fibroblast|0/1|
|gastric|1/16|
|kidney|1/21|
|liver|1/20|
|lung|8/75|
|lymphocyte|1/16|
|ovary|0/26|
|pancreas|1/24|
|peripheral nervous system|0/16|
|plasma cell|1/15|
|prostate|0/1|
|skin|2/24|
|soft tissue|1/9|
|thyroid|0/2|
|upper aerodigestive|1/22|
|urinary tract|1/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2561
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.18 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MRPL32 Expression in NALM6 Cells: 6.18'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>