MRPL49 [The Human Chemical-Genetic Interaction Map Project]

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======= MRPL49 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MRPL49
  * **<color #00a2e8>Official Name</color>**: mitochondrial ribosomal protein L49
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=740|740]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q13405|Q13405]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MRPL49&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MRPL49|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606866|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Img2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|mitochondrial ribosome|
|mitochondrial large ribosomal subunit|
|mitochondrial translational termination|
|mitochondrial translational elongation|
|translational termination|
|mitochondrial translation|
|translational elongation|
|cellular protein complex disassembly|
|mitochondrial gene expression|
|structural constituent of ribosome|
|protein-containing complex disassembly|
|translation|
|mitochondrial inner membrane|
|cellular component disassembly|
|peptide biosynthetic process|
|amide biosynthetic process|
|peptide metabolic process|
|cellular amide metabolic process|
|mitochondrion|
|organonitrogen compound biosynthetic process|
|cellular nitrogen compound biosynthetic process|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|protein-containing complex subunit organization|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|1.79|
|[[:results:exp441|GSK-J4 1.5μM R08 exp441]]|1.86|
|[[:results:exp350|Deferoxamine 11μM R07 exp350]]|1.94|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|1.98|
|[[:results:exp78|Pterostilbene 16μM R02 exp78]]|2.13|
|[[:results:exp75|MK-1775 0.32μM R02 exp75]]|2.38|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:c:coa3|COA3]]|0.559|
|[[:human genes:p:pet117|PET117]]|0.553|
|[[:human genes:m:malsu1|MALSU1]]|0.55|
|[[:human genes:f:ftsj2|FTSJ2]]|0.529|
|[[:human genes:l:lars2|LARS2]]|0.518|
|[[:human genes:q:qrsl1|QRSL1]]|0.518|
|[[:human genes:p:pet112|PET112]]|0.511|
|[[:human genes:n:nars2|NARS2]]|0.505|
|[[:human genes:c:chchd1|CHCHD1]]|0.502|
|[[:human genes:r:rpusd3|RPUSD3]]|0.498|
|[[:human genes:a:aars2|AARS2]]|0.496|
|[[:human genes:m:mrpl45|MRPL45]]|0.496|
|[[:human genes:m:mrps12|MRPS12]]|0.491|
|[[:human genes:e:eral1|ERAL1]]|0.488|
|[[:human genes:t:tfb1m|TFB1M]]|0.476|
|[[:human genes:m:mrpl21|MRPL21]]|0.474|
|[[:human genes:n:nsun4|NSUN4]]|0.474|
|[[:human genes:h:hmgxb3|HMGXB3]]|0.467|
|[[:human genes:m:mrpl39|MRPL39]]|0.467|
|[[:human genes:c:cox11|COX11]]|0.467|
|[[:human genes:m:mrps25|MRPS25]]|0.464|
|[[:human genes:m:mrp63|MRP63]]|0.463|
|[[:human genes:c:cars2|CARS2]]|0.463|
|[[:human genes:s:selrc1|SELRC1]]|0.462|
|[[:human genes:h:hsd17b10|HSD17B10]]|0.462|
|[[:human genes:m:mrpl23|MRPL23]]|0.46|
|[[:human genes:d:ddx28|DDX28]]|0.458|
|[[:human genes:m:mrps22|MRPS22]]|0.455|
|[[:human genes:m:mettl17|METTL17]]|0.453|
|[[:human genes:g:gfm2|GFM2]]|0.452|
|[[:human genes:m:mrps5|MRPS5]]|0.449|
|[[:human genes:m:mrpl37|MRPL37]]|0.448|
|[[:human genes:p:prepl|PREPL]]|0.445|
|[[:human genes:m:mrpl53|MRPL53]]|0.445|
|[[:human genes:s:ssbp1|SSBP1]]|0.444|
|[[:human genes:f:fastkd5|FASTKD5]]|0.444|
|[[:human genes:m:mrps35|MRPS35]]|0.443|
|[[:human genes:t:tars2|TARS2]]|0.443|
|[[:human genes:n:ndufs2|NDUFS2]]|0.441|
|[[:human genes:w:wbscr16|WBSCR16]]|0.44|
|[[:human genes:a:acad9|ACAD9]]|0.439|
|[[:human genes:c:coa6|COA6]]|0.439|
|[[:human genes:g:gfm1|GFM1]]|0.438|
|[[:human genes:m:mtg1|MTG1]]|0.437|
|[[:human genes:m:mrps21|MRPS21]]|0.431|
|[[:human genes:f:fars2|FARS2]]|0.431|
|[[:human genes:m:mrpl18|MRPL18]]|0.431|
|[[:human genes:e:ears2|EARS2]]|0.428|
|[[:human genes:y:yars2|YARS2]]|0.427|
|[[:human genes:m:mrps26|MRPS26]]|0.426|
|[[:human genes:f:fastkd2|FASTKD2]]|0.426|
|[[:human genes:m:mrpl3|MRPL3]]|0.425|
|[[:human genes:m:mrps27|MRPS27]]|0.425|
|[[:human genes:m:mtpap|MTPAP]]|0.425|
|[[:human genes:m:mrps16|MRPS16]]|0.423|
|[[:human genes:t:trub2|TRUB2]]|0.422|
|[[:human genes:m:mrpl43|MRPL43]]|0.422|
|[[:human genes:t:tomm20|TOMM20]]|0.421|
|[[:human genes:r:rpusd4|RPUSD4]]|0.42|
|[[:human genes:s:slc31a1|SLC31A1]]|0.419|
|[[:human genes:m:mrpl17|MRPL17]]|0.418|
|[[:human genes:n:ndufb11|NDUFB11]]|0.417|
|[[:human genes:m:mars2|MARS2]]|0.417|
|[[:human genes:m:mterfd1|MTERFD1]]|0.415|
|[[:human genes:n:ndufaf5|NDUFAF5]]|0.415|
|[[:human genes:g:gtpbp8|GTPBP8]]|0.414|
|[[:human genes:m:mrpl47|MRPL47]]|0.414|
|[[:human genes:m:mrps34|MRPS34]]|0.414|
|[[:human genes:x:xpnpep3|XPNPEP3]]|0.414|
|[[:human genes:m:mrpl9|MRPL9]]|0.413|
|[[:human genes:p:ptcd3|PTCD3]]|0.412|
|[[:human genes:m:mrpl55|MRPL55]]|0.41|
|[[:human genes:v:vars2|VARS2]]|0.409|
|[[:human genes:n:ndufa1|NDUFA1]]|0.408|
|[[:human genes:m:mrpl4|MRPL4]]|0.408|
|[[:human genes:g:gtpbp10|GTPBP10]]|0.408|
|[[:human genes:p:pnpt1|PNPT1]]|0.407|
|[[:human genes:d:dars2|DARS2]]|0.406|
|[[:human genes:r:rbfa|RBFA]]|0.406|
|[[:human genes:p:ptcd1|PTCD1]]|0.406|
|[[:human genes:m:mpv17l2|MPV17L2]]|0.406|
|[[:human genes:m:mcat|MCAT]]|0.405|
|[[:human genes:m:mtg2|MTG2]]|0.404|
|[[:human genes:r:rars2|RARS2]]|0.404|
|[[:human genes:c:cox19|COX19]]|0.401|
|[[:human genes:d:dap3|DAP3]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 210/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|7/28|
|blood|6/28|
|bone|6/26|
|breast|9/33|
|central nervous system|8/56|
|cervix|2/4|
|colorectal|2/17|
|esophagus|6/13|
|fibroblast|0/1|
|gastric|6/16|
|kidney|4/21|
|liver|11/20|
|lung|21/75|
|lymphocyte|5/16|
|ovary|4/26|
|pancreas|4/24|
|peripheral nervous system|4/16|
|plasma cell|4/15|
|prostate|0/1|
|skin|10/24|
|soft tissue|4/9|
|thyroid|0/2|
|upper aerodigestive|11/22|
|urinary tract|9/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 770
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.27 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MRPL49 Expression in NALM6 Cells: 5.27'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>