MRPL9 [The Human Chemical-Genetic Interaction Map Project]

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======= MRPL9 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MRPL9
  * **<color #00a2e8>Official Name</color>**: mitochondrial ribosomal protein L9
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=65005|65005]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9BYD2|Q9BYD2]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MRPL9&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MRPL9|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/611824|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Ribosomal L9 N|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|mitochondrial ribosome|
|mitochondrial large ribosomal subunit|
|mitochondrial translational elongation|
|mitochondrial translational termination|
|translational termination|
|mitochondrial translation|
|translational elongation|
|cellular protein complex disassembly|
|mitochondrial gene expression|
|structural constituent of ribosome|
|protein-containing complex disassembly|
|translation|
|mitochondrial inner membrane|
|cellular component disassembly|
|peptide biosynthetic process|
|amide biosynthetic process|
|peptide metabolic process|
|cellular amide metabolic process|
|mitochondrion|
|RNA binding|
|organonitrogen compound biosynthetic process|
|cellular nitrogen compound biosynthetic process|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|protein-containing complex subunit organization|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp441|GSK-J4 1.5μM R08 exp441]]|1.75|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|1.86|
|[[:results:exp78|Pterostilbene 16μM R02 exp78]]|2.05|
|[[:results:exp228|Demecolcine 0.03μM R05 exp228]]|2.11|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:m:mrps34|MRPS34]]|0.513|
|[[:human genes:m:mrps27|MRPS27]]|0.463|
|[[:human genes:p:polrmt|POLRMT]]|0.449|
|[[:human genes:m:mrp63|MRP63]]|0.449|
|[[:human genes:m:mrps26|MRPS26]]|0.446|
|[[:human genes:d:ddx28|DDX28]]|0.441|
|[[:human genes:m:mrps9|MRPS9]]|0.432|
|[[:human genes:m:mrps2|MRPS2]]|0.432|
|[[:human genes:m:mrpl44|MRPL44]]|0.43|
|[[:human genes:p:pnpt1|PNPT1]]|0.423|
|[[:human genes:h:hsd17b10|HSD17B10]]|0.419|
|[[:human genes:m:mrps24|MRPS24]]|0.419|
|[[:human genes:f:fars2|FARS2]]|0.419|
|[[:human genes:c:coa3|COA3]]|0.416|
|[[:human genes:m:mrpl35|MRPL35]]|0.415|
|[[:human genes:p:pet117|PET117]]|0.415|
|[[:human genes:m:mrpl49|MRPL49]]|0.413|
|[[:human genes:m:mrpl37|MRPL37]]|0.412|
|[[:human genes:y:yars2|YARS2]]|0.407|
|[[:human genes:m:mrpl21|MRPL21]]|0.405|
|[[:human genes:q:qrsl1|QRSL1]]|0.402|
|[[:human genes:d:dars2|DARS2]]|0.402|
|[[:human genes:m:mtrf1l|MTRF1L]]|0.402|
|[[:human genes:m:mrps21|MRPS21]]|0.402|
|[[:human genes:s:sars2|SARS2]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 19/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|1/26|
|breast|1/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|1/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|1/16|
|kidney|0/21|
|liver|0/20|
|lung|4/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|1/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|1/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1286
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.51 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MRPL9 Expression in NALM6 Cells: 5.51'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>