MRPS18B [The Human Chemical-Genetic Interaction Map Project]

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======= MRPS18B =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MRPS18B
  * **<color #00a2e8>Official Name</color>**: mitochondrial ribosomal protein S18B
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=28973|28973]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y676|Q9Y676]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MRPS18B&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MRPS18B|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/611982|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Ribosomal S18|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|mitochondrial small ribosomal subunit|
|mitochondrial translational termination|
|mitochondrial translational elongation|
|translational termination|
|mitochondrial translation|
|translational elongation|
|cellular protein complex disassembly|
|mitochondrial gene expression|
|structural constituent of ribosome|
|protein-containing complex disassembly|
|translation|
|mitochondrial inner membrane|
|cellular component disassembly|
|peptide biosynthetic process|
|amide biosynthetic process|
|peptide metabolic process|
|cell junction|
|cellular amide metabolic process|
|mitochondrion|
|organonitrogen compound biosynthetic process|
|cellular nitrogen compound biosynthetic process|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|protein-containing complex subunit organization|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp264|Arsenate 40μM R06 exp264]]|1.73|
|[[:results:exp65|Mubritinib 0.2μM R02 exp65]]|1.86|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:pet117|PET117]]|0.506|
|[[:human genes:g:grsf1|GRSF1]]|0.503|
|[[:human genes:m:mrpl3|MRPL3]]|0.497|
|[[:human genes:n:ndufs2|NDUFS2]]|0.495|
|[[:human genes:n:nars2|NARS2]]|0.488|
|[[:human genes:m:mto1|MTO1]]|0.484|
|[[:human genes:n:nsun4|NSUN4]]|0.479|
|[[:human genes:p:pde12|PDE12]]|0.457|
|[[:human genes:c:cars2|CARS2]]|0.456|
|[[:human genes:r:rmnd1|RMND1]]|0.448|
|[[:human genes:q:qrsl1|QRSL1]]|0.448|
|[[:human genes:n:ndufb10|NDUFB10]]|0.448|
|[[:human genes:w:wars2|WARS2]]|0.446|
|[[:human genes:t:tfb1m|TFB1M]]|0.444|
|[[:human genes:m:mrpl43|MRPL43]]|0.437|
|[[:human genes:n:ndufa1|NDUFA1]]|0.437|
|[[:human genes:e:eral1|ERAL1]]|0.437|
|[[:human genes:n:ndufaf3|NDUFAF3]]|0.437|
|[[:human genes:s:ssbp1|SSBP1]]|0.437|
|[[:human genes:a:acad9|ACAD9]]|0.436|
|[[:human genes:g:gfm1|GFM1]]|0.435|
|[[:human genes:l:lars2|LARS2]]|0.434|
|[[:human genes:p:ptcd3|PTCD3]]|0.434|
|[[:human genes:f:ftsj2|FTSJ2]]|0.432|
|[[:human genes:c:coa3|COA3]]|0.431|
|[[:human genes:g:gtpbp8|GTPBP8]]|0.431|
|[[:human genes:x:xpnpep3|XPNPEP3]]|0.431|
|[[:human genes:m:mrpl37|MRPL37]]|0.43|
|[[:human genes:n:ndufaf7|NDUFAF7]]|0.427|
|[[:human genes:n:ndufc2|NDUFC2]]|0.426|
|[[:human genes:m:mrpl48|MRPL48]]|0.425|
|[[:human genes:a:aars2|AARS2]]|0.422|
|[[:human genes:m:mcat|MCAT]]|0.422|
|[[:human genes:n:ndufs5|NDUFS5]]|0.421|
|[[:human genes:n:ndufb11|NDUFB11]]|0.421|
|[[:human genes:r:rars2|RARS2]]|0.421|
|[[:human genes:m:mrpl45|MRPL45]]|0.421|
|[[:human genes:d:dap3|DAP3]]|0.419|
|[[:human genes:m:mrps21|MRPS21]]|0.419|
|[[:human genes:m:mtrf1l|MTRF1L]]|0.418|
|[[:human genes:f:fastkd2|FASTKD2]]|0.417|
|[[:human genes:m:mrps9|MRPS9]]|0.416|
|[[:human genes:h:hmgxb3|HMGXB3]]|0.416|
|[[:human genes:m:mrps27|MRPS27]]|0.416|
|[[:human genes:n:nubpl|NUBPL]]|0.415|
|[[:human genes:m:mettl17|METTL17]]|0.415|
|[[:human genes:m:mipep|MIPEP]]|0.415|
|[[:human genes:h:hsd17b10|HSD17B10]]|0.415|
|[[:human genes:m:mrps22|MRPS22]]|0.414|
|[[:human genes:g:gtpbp10|GTPBP10]]|0.413|
|[[:human genes:p:prepl|PREPL]]|0.412|
|[[:human genes:n:ndufa11|NDUFA11]]|0.412|
|[[:human genes:r:rpusd4|RPUSD4]]|0.411|
|[[:human genes:t:tars2|TARS2]]|0.41|
|[[:human genes:m:mtif2|MTIF2]]|0.41|
|[[:human genes:d:dars2|DARS2]]|0.41|
|[[:human genes:n:ndufb9|NDUFB9]]|0.405|
|[[:human genes:p:pet112|PET112]]|0.405|
|[[:human genes:n:ndufa3|NDUFA3]]|0.404|
|[[:human genes:n:ndufa2|NDUFA2]]|0.404|
|[[:human genes:m:mrpl47|MRPL47]]|0.401|
|[[:human genes:m:mrp63|MRP63]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 41/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|2/28|
|blood|1/28|
|bone|1/26|
|breast|4/33|
|central nervous system|2/56|
|cervix|0/4|
|colorectal|3/17|
|esophagus|2/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|2/21|
|liver|2/20|
|lung|6/75|
|lymphocyte|2/16|
|ovary|0/26|
|pancreas|1/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|2/22|
|urinary tract|2/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 868
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.81 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MRPS18B Expression in NALM6 Cells: 5.81'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>