MRPS21 [The Human Chemical-Genetic Interaction Map Project]

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======= MRPS21 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MRPS21
  * **<color #00a2e8>Official Name</color>**: mitochondrial ribosomal protein S21
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=54460|54460]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P82921|P82921]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MRPS21&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MRPS21|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/611984|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Ribosomal S21|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|mitochondrial small ribosomal subunit|
|mitochondrial translational elongation|
|mitochondrial translational termination|
|translational termination|
|mitochondrial translation|
|translational elongation|
|cellular protein complex disassembly|
|mitochondrial gene expression|
|structural constituent of ribosome|
|protein-containing complex disassembly|
|translation|
|mitochondrial inner membrane|
|cellular component disassembly|
|peptide biosynthetic process|
|amide biosynthetic process|
|peptide metabolic process|
|cellular amide metabolic process|
|RNA binding|
|organonitrogen compound biosynthetic process|
|cellular nitrogen compound biosynthetic process|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|protein-containing complex subunit organization|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp165|RO-3306 3 to 4μM on day4 R04 exp165]]|-1.77|
|[[:results:exp321|ABT-702 5μM plus Deferoxamine 11μM R07 exp321]]|1.75|
|[[:results:exp527|Tanespimycin 14μM R08 exp527]]|1.76|
|[[:results:exp513|ONC212 0.15μM R08 exp513]]|1.78|
|[[:results:exp469|CFI-400945 25μM R08 exp469]]|1.8|
|[[:results:exp472|CI-1040 9.5μM R08 exp472]]|1.82|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|1.88|
|[[:results:exp492|iCRT14 30μM R08 exp492]]|1.9|
|[[:results:exp66|BI-D1870 3.15μM R02 exp66]]|1.98|
|[[:results:exp160|Ribavirin 10 to 15μM on day4 R04 exp160]]|2.05|
|[[:results:exp468|CB-5083 0.4μM R08 exp468]]|2.06|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|2.16|
|[[:results:exp360|Genistein 15μM R07 exp360]]|2.23|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|2.23|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|2.3|
|[[:results:exp48|Mubritinib 0.2μM R01 exp48]]|2.41|
|[[:results:exp441|GSK-J4 1.5μM R08 exp441]]|2.43|
|[[:results:exp350|Deferoxamine 11μM R07 exp350]]|2.45|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|2.76|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|2.91|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|3.03|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:y:yars2|YARS2]]|0.748|
|[[:human genes:h:hsd17b10|HSD17B10]]|0.745|
|[[:human genes:m:mrpl21|MRPL21]]|0.735|
|[[:human genes:m:mrps6|MRPS6]]|0.731|
|[[:human genes:n:nars2|NARS2]]|0.723|
|[[:human genes:d:dap3|DAP3]]|0.72|
|[[:human genes:m:mrpl53|MRPL53]]|0.706|
|[[:human genes:g:gfm1|GFM1]]|0.697|
|[[:human genes:e:ears2|EARS2]]|0.695|
|[[:human genes:m:mrpl23|MRPL23]]|0.694|
|[[:human genes:m:mrps16|MRPS16]]|0.693|
|[[:human genes:t:tars2|TARS2]]|0.692|
|[[:human genes:q:qrsl1|QRSL1]]|0.692|
|[[:human genes:v:vars2|VARS2]]|0.688|
|[[:human genes:m:mrps5|MRPS5]]|0.687|
|[[:human genes:s:selrc1|SELRC1]]|0.683|
|[[:human genes:l:lars2|LARS2]]|0.683|
|[[:human genes:r:rpusd4|RPUSD4]]|0.678|
|[[:human genes:f:fastkd5|FASTKD5]]|0.674|
|[[:human genes:r:rbfa|RBFA]]|0.673|
|[[:human genes:c:cox16|COX16]]|0.672|
|[[:human genes:n:ndufb11|NDUFB11]]|0.67|
|[[:human genes:r:rars2|RARS2]]|0.669|
|[[:human genes:f:ftsj2|FTSJ2]]|0.663|
|[[:human genes:p:pars2|PARS2]]|0.658|
|[[:human genes:t:tefm|TEFM]]|0.657|
|[[:human genes:m:mrps34|MRPS34]]|0.655|
|[[:human genes:m:mars2|MARS2]]|0.645|
|[[:human genes:m:mrp63|MRP63]]|0.644|
|[[:human genes:s:sco2|SCO2]]|0.643|
|[[:human genes:h:hars2|HARS2]]|0.642|
|[[:human genes:m:mrps14|MRPS14]]|0.641|
|[[:human genes:d:dars2|DARS2]]|0.638|
|[[:human genes:m:mrps18a|MRPS18A]]|0.638|
|[[:human genes:c:coa3|COA3]]|0.635|
|[[:human genes:m:mrps26|MRPS26]]|0.631|
|[[:human genes:n:ndufa3|NDUFA3]]|0.628|
|[[:human genes:p:pet112|PET112]]|0.627|
|[[:human genes:s:supv3l1|SUPV3L1]]|0.626|
|[[:human genes:m:mrpl47|MRPL47]]|0.62|
|[[:human genes:s:sars2|SARS2]]|0.613|
|[[:human genes:c:c10orf2|C10orf2]]|0.611|
|[[:human genes:g:gatc|GATC]]|0.609|
|[[:human genes:m:mrps10|MRPS10]]|0.608|
|[[:human genes:p:pdss1|PDSS1]]|0.604|
|[[:human genes:n:ndufc2|NDUFC2]]|0.6|
|[[:human genes:c:c12orf65|C12orf65]]|0.6|
|[[:human genes:p:pnpt1|PNPT1]]|0.598|
|[[:human genes:m:mrpl12|MRPL12]]|0.598|
|[[:human genes:r:rpusd3|RPUSD3]]|0.597|
|[[:human genes:t:tufm|TUFM]]|0.597|
|[[:human genes:m:mtg2|MTG2]]|0.592|
|[[:human genes:m:mrpl45|MRPL45]]|0.591|
|[[:human genes:c:cox17|COX17]]|0.59|
|[[:human genes:r:rnaseh1|RNASEH1]]|0.59|
|[[:human genes:m:mrps25|MRPS25]]|0.59|
|[[:human genes:n:ndufaf7|NDUFAF7]]|0.589|
|[[:human genes:t:tomm20|TOMM20]]|0.589|
|[[:human genes:m:mrps12|MRPS12]]|0.589|
|[[:human genes:g:gtpbp10|GTPBP10]]|0.588|
|[[:human genes:w:wbscr16|WBSCR16]]|0.588|
|[[:human genes:p:polg2|POLG2]]|0.586|
|[[:human genes:k:kiaa0391|KIAA0391]]|0.585|
|[[:human genes:m:mrpl3|MRPL3]]|0.583|
|[[:human genes:m:mrpl42|MRPL42]]|0.583|
|[[:human genes:a:aars2|AARS2]]|0.582|
|[[:human genes:c:cox15|COX15]]|0.581|
|[[:human genes:r:rtn4ip1|RTN4IP1]]|0.581|
|[[:human genes:t:trub2|TRUB2]]|0.58|
|[[:human genes:b:bcs1l|BCS1L]]|0.58|
|[[:human genes:m:mrps9|MRPS9]]|0.579|
|[[:human genes:m:mrps33|MRPS33]]|0.578|
|[[:human genes:m:mrpl15|MRPL15]]|0.578|
|[[:human genes:p:pet117|PET117]]|0.575|
|[[:human genes:m:mrps35|MRPS35]]|0.573|
|[[:human genes:c:coa6|COA6]]|0.572|
|[[:human genes:m:mrps2|MRPS2]]|0.568|
|[[:human genes:c:cox7b|COX7B]]|0.568|
|[[:human genes:m:mrps24|MRPS24]]|0.562|
|[[:human genes:m:mettl17|METTL17]]|0.562|
|[[:human genes:g:gfm2|GFM2]]|0.561|
|[[:human genes:m:mrpl55|MRPL55]]|0.56|
|[[:human genes:n:ndufa2|NDUFA2]]|0.559|
|[[:human genes:m:mtg1|MTG1]]|0.559|
|[[:human genes:f:fars2|FARS2]]|0.556|
|[[:human genes:m:mrpl18|MRPL18]]|0.553|
|[[:human genes:a:atp5sl|ATP5SL]]|0.553|
|[[:human genes:m:mrpl20|MRPL20]]|0.551|
|[[:human genes:m:mtrf1l|MTRF1L]]|0.551|
|[[:human genes:p:polrmt|POLRMT]]|0.55|
|[[:human genes:n:ndufa1|NDUFA1]]|0.55|
|[[:human genes:m:mrpl43|MRPL43]]|0.547|
|[[:human genes:c:cars2|CARS2]]|0.546|
|[[:human genes:n:ndufa11|NDUFA11]]|0.546|
|[[:human genes:a:aifm1|AIFM1]]|0.545|
|[[:human genes:c:c17orf89|C17orf89]]|0.542|
|[[:human genes:m:mrps28|MRPS28]]|0.541|
|[[:human genes:t:tfb1m|TFB1M]]|0.541|
|[[:human genes:c:chchd1|CHCHD1]]|0.537|
|[[:human genes:m:mrpl44|MRPL44]]|0.537|
|[[:human genes:m:mtif2|MTIF2]]|0.536|
|[[:human genes:m:mrpl4|MRPL4]]|0.535|
|[[:human genes:m:mtpap|MTPAP]]|0.535|
|[[:human genes:a:acad9|ACAD9]]|0.534|
|[[:human genes:m:malsu1|MALSU1]]|0.53|
|[[:human genes:c:cox6c|COX6C]]|0.529|
|[[:human genes:s:slc25a26|SLC25A26]]|0.526|
|[[:human genes:t:tmem261|TMEM261]]|0.525|
|[[:human genes:t:trmt10c|TRMT10C]]|0.525|
|[[:human genes:n:ndufs2|NDUFS2]]|0.524|
|[[:human genes:g:grsf1|GRSF1]]|0.523|
|[[:human genes:m:mrpl33|MRPL33]]|0.523|
|[[:human genes:m:mrpl46|MRPL46]]|0.522|
|[[:human genes:c:coq2|COQ2]]|0.521|
|[[:human genes:n:ndufb5|NDUFB5]]|0.52|
|[[:human genes:f:fh|FH]]|0.518|
|[[:human genes:t:tomm22|TOMM22]]|0.516|
|[[:human genes:m:mrpl36|MRPL36]]|0.515|
|[[:human genes:n:ndufc1|NDUFC1]]|0.515|
|[[:human genes:m:mrps7|MRPS7]]|0.515|
|[[:human genes:a:atp5d|ATP5D]]|0.514|
|[[:human genes:m:mrpl17|MRPL17]]|0.514|
|[[:human genes:m:mrps27|MRPS27]]|0.513|
|[[:human genes:u:uqcr10|UQCR10]]|0.513|
|[[:human genes:m:mterfd1|MTERFD1]]|0.513|
|[[:human genes:n:ndufaf4|NDUFAF4]]|0.512|
|[[:human genes:u:uqcrc2|UQCRC2]]|0.511|
|[[:human genes:t:tfam|TFAM]]|0.511|
|[[:human genes:m:mrpl51|MRPL51]]|0.51|
|[[:human genes:n:ndufs7|NDUFS7]]|0.51|
|[[:human genes:p:polg|POLG]]|0.51|
|[[:human genes:m:mrps23|MRPS23]]|0.51|
|[[:human genes:c:cox11|COX11]]|0.509|
|[[:human genes:m:mrpl11|MRPL11]]|0.509|
|[[:human genes:m:mipep|MIPEP]]|0.509|
|[[:human genes:r:rnmtl1|RNMTL1]]|0.507|
|[[:human genes:m:mrpl34|MRPL34]]|0.504|
|[[:human genes:m:mrps17|MRPS17]]|0.504|
|[[:human genes:m:mrpl35|MRPL35]]|0.503|
|[[:human genes:f:fastkd2|FASTKD2]]|0.502|
|[[:human genes:n:ndufv1|NDUFV1]]|0.501|
|[[:human genes:c:coq7|COQ7]]|0.5|
|[[:human genes:a:atp5a1|ATP5A1]]|0.499|
|[[:human genes:g:gtpbp8|GTPBP8]]|0.498|
|[[:human genes:m:mrpl22|MRPL22]]|0.495|
|[[:human genes:e:ecsit|ECSIT]]|0.495|
|[[:human genes:m:mterfd2|MTERFD2]]|0.494|
|[[:human genes:n:ndufb3|NDUFB3]]|0.494|
|[[:human genes:h:hmgxb3|HMGXB3]]|0.493|
|[[:human genes:n:ndufb6|NDUFB6]]|0.492|
|[[:human genes:p:ptcd3|PTCD3]]|0.49|
|[[:human genes:n:ndufaf3|NDUFAF3]]|0.489|
|[[:human genes:n:ndufb9|NDUFB9]]|0.488|
|[[:human genes:m:mrpl1|MRPL1]]|0.488|
|[[:human genes:m:mrpl41|MRPL41]]|0.487|
|[[:human genes:m:mtif3|MTIF3]]|0.486|
|[[:human genes:m:mto1|MTO1]]|0.485|
|[[:human genes:l:lrpprc|LRPPRC]]|0.484|
|[[:human genes:m:mrpl13|MRPL13]]|0.484|
|[[:human genes:w:wars2|WARS2]]|0.483|
|[[:human genes:m:mrps11|MRPS11]]|0.483|
|[[:human genes:c:cox6b1|COX6B1]]|0.482|
|[[:human genes:a:atp5c1|ATP5C1]]|0.479|
|[[:human genes:p:pgm3|PGM3]]|0.478|
|[[:human genes:d:ddx28|DDX28]]|0.477|
|[[:human genes:u:uqcrc1|UQCRC1]]|0.476|
|[[:human genes:n:nubpl|NUBPL]]|0.472|
|[[:human genes:h:higd2a|HIGD2A]]|0.472|
|[[:human genes:m:mrps22|MRPS22]]|0.471|
|[[:human genes:a:atp5b|ATP5B]]|0.47|
|[[:human genes:n:ndufa10|NDUFA10]]|0.47|
|[[:human genes:g:gtpbp6|GTPBP6]]|0.469|
|[[:human genes:n:ndufb4|NDUFB4]]|0.468|
|[[:human genes:e:elac2|ELAC2]]|0.467|
|[[:human genes:n:ndufaf5|NDUFAF5]]|0.466|
|[[:human genes:s:ssbp1|SSBP1]]|0.464|
|[[:human genes:n:ndufb7|NDUFB7]]|0.463|
|[[:human genes:c:c1qbp|C1QBP]]|0.462|
|[[:human genes:t:tmem242|TMEM242]]|0.461|
|[[:human genes:r:rpia|RPIA]]|0.461|
|[[:human genes:c:coq4|COQ4]]|0.46|
|[[:human genes:c:clpp|CLPP]]|0.46|
|[[:human genes:c:chchd4|CHCHD4]]|0.459|
|[[:human genes:m:mrpl27|MRPL27]]|0.458|
|[[:human genes:m:mrpl2|MRPL2]]|0.458|
|[[:human genes:c:cox5a|COX5A]]|0.458|
|[[:human genes:m:mrpl52|MRPL52]]|0.456|
|[[:human genes:t:timmdc1|TIMMDC1]]|0.454|
|[[:human genes:d:dnlz|DNLZ]]|0.453|
|[[:human genes:c:cox19|COX19]]|0.452|
|[[:human genes:m:mcat|MCAT]]|0.451|
|[[:human genes:n:nfu1|NFU1]]|0.451|
|[[:human genes:m:mrpl39|MRPL39]]|0.45|
|[[:human genes:a:atp5h|ATP5H]]|0.449|
|[[:human genes:m:mrpl28|MRPL28]]|0.449|
|[[:human genes:t:tomm7|TOMM7]]|0.448|
|[[:human genes:n:nsun4|NSUN4]]|0.446|
|[[:human genes:c:cox20|COX20]]|0.446|
|[[:human genes:e:eral1|ERAL1]]|0.445|
|[[:human genes:i:iba57|IBA57]]|0.444|
|[[:human genes:t:tomm6|TOMM6]]|0.444|
|[[:human genes:a:alas1|ALAS1]]|0.443|
|[[:human genes:g:glrx5|GLRX5]]|0.443|
|[[:human genes:m:mrpl37|MRPL37]]|0.442|
|[[:human genes:d:dhrsx|DHRSX]]|0.441|
|[[:human genes:n:ndufs1|NDUFS1]]|0.44|
|[[:human genes:o:opa1|OPA1]]|0.439|
|[[:human genes:c:coq5|COQ5]]|0.436|
|[[:human genes:m:mrpl48|MRPL48]]|0.435|
|[[:human genes:n:ndufa8|NDUFA8]]|0.435|
|[[:human genes:i:ict1|ICT1]]|0.434|
|[[:human genes:m:mrpl49|MRPL49]]|0.431|
|[[:human genes:c:coq3|COQ3]]|0.431|
|[[:human genes:u:uqcrq|UQCRQ]]|0.431|
|[[:human genes:n:ndufb1|NDUFB1]]|0.431|
|[[:human genes:p:ppa2|PPA2]]|0.431|
|[[:human genes:p:ptcd1|PTCD1]]|0.431|
|[[:human genes:t:triap1|TRIAP1]]|0.43|
|[[:human genes:a:aasdhppt|AASDHPPT]]|0.43|
|[[:human genes:n:ndufa6|NDUFA6]]|0.429|
|[[:human genes:u:uqcc2|UQCC2]]|0.429|
|[[:human genes:t:tfb2m|TFB2M]]|0.427|
|[[:human genes:n:ndufaf6|NDUFAF6]]|0.427|
|[[:human genes:c:coa5|COA5]]|0.423|
|[[:human genes:t:trmt61a|TRMT61A]]|0.421|
|[[:human genes:n:ndufs5|NDUFS5]]|0.421|
|[[:human genes:c:cox7c|COX7C]]|0.419|
|[[:human genes:n:ndufb2|NDUFB2]]|0.419|
|[[:human genes:m:mrps18b|MRPS18B]]|0.419|
|[[:human genes:t:timm8b|TIMM8B]]|0.418|
|[[:human genes:t:tmem126b|TMEM126B]]|0.417|
|[[:human genes:m:minos1|MINOS1]]|0.417|
|[[:human genes:t:tomm40|TOMM40]]|0.417|
|[[:human genes:a:atp5o|ATP5O]]|0.417|
|[[:human genes:p:ppcs|PPCS]]|0.416|
|[[:human genes:f:fastkd1|FASTKD1]]|0.414|
|[[:human genes:n:ndufa13|NDUFA13]]|0.413|
|[[:human genes:s:slc25a3|SLC25A3]]|0.413|
|[[:human genes:a:alg6|ALG6]]|0.411|
|[[:human genes:h:hccs|HCCS]]|0.411|
|[[:human genes:n:ndufaf1|NDUFAF1]]|0.41|
|[[:human genes:n:noa1|NOA1]]|0.409|
|[[:human genes:p:pet100|PET100]]|0.407|
|[[:human genes:d:dhx30|DHX30]]|0.407|
|[[:human genes:n:ndufs8|NDUFS8]]|0.406|
|[[:human genes:a:atxn10|ATXN10]]|0.406|
|[[:human genes:a:atic|ATIC]]|0.406|
|[[:human genes:s:slc25a52|SLC25A52]]|0.405|
|[[:human genes:t:timm17a|TIMM17A]]|0.403|
|[[:human genes:m:mrpl9|MRPL9]]|0.402|
|[[:human genes:c:coq6|COQ6]]|0.401|
|[[:human genes:s:srd5a3|SRD5A3]]|0.401|
|[[:human genes:n:ndufs3|NDUFS3]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 342/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|1/1|
|bile duct|15/28|
|blood|10/28|
|bone|15/26|
|breast|16/33|
|central nervous system|24/56|
|cervix|2/4|
|colorectal|12/17|
|esophagus|8/13|
|fibroblast|1/1|
|gastric|12/16|
|kidney|7/21|
|liver|9/20|
|lung|34/75|
|lymphocyte|4/16|
|ovary|4/26|
|pancreas|8/24|
|peripheral nervous system|6/16|
|plasma cell|3/15|
|prostate|1/1|
|skin|12/24|
|soft tissue|4/9|
|thyroid|0/2|
|upper aerodigestive|12/22|
|urinary tract|13/29|
|uterus|3/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 167
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.05 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MRPS21 Expression in NALM6 Cells: 5.05'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>