MRPS22 [The Human Chemical-Genetic Interaction Map Project]

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======= MRPS22 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MRPS22
  * **<color #00a2e8>Official Name</color>**: mitochondrial ribosomal protein S22
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=56945|56945]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P82650|P82650]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MRPS22&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MRPS22|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605810|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that does not seem to have a counterpart in prokaryotic and fungal-mitochondrial ribosomes. This gene lies telomeric of and is transcribed in the opposite direction from the forkhead box L2 gene. A pseudogene corresponding to this gene is found on chromosome Xq. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|MRP-S22|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|mitochondrial ribosome|
|mitochondrial small ribosomal subunit|
|mitochondrial translational elongation|
|mitochondrial translational termination|
|translational termination|
|mitochondrial translation|
|translational elongation|
|cellular protein complex disassembly|
|mitochondrial gene expression|
|structural constituent of ribosome|
|protein-containing complex disassembly|
|translation|
|mitochondrial inner membrane|
|cellular component disassembly|
|peptide biosynthetic process|
|amide biosynthetic process|
|peptide metabolic process|
|cellular amide metabolic process|
|mitochondrion|
|organonitrogen compound biosynthetic process|
|cellular nitrogen compound biosynthetic process|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|protein-containing complex subunit organization|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp300|VE-822 0.04μM R06 exp300]]|-1.89|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|1.74|
|[[:results:exp116|AICAR 240μM R03 exp116]]|2.25|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|2.62|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:q:qrsl1|QRSL1]]|0.573|
|[[:human genes:n:nars2|NARS2]]|0.572|
|[[:human genes:m:mrps16|MRPS16]]|0.56|
|[[:human genes:r:rars2|RARS2]]|0.553|
|[[:human genes:m:mrps6|MRPS6]]|0.551|
|[[:human genes:h:hsd17b10|HSD17B10]]|0.545|
|[[:human genes:d:dap3|DAP3]]|0.541|
|[[:human genes:r:rpusd4|RPUSD4]]|0.537|
|[[:human genes:g:gtpbp10|GTPBP10]]|0.536|
|[[:human genes:s:sco2|SCO2]]|0.535|
|[[:human genes:e:eral1|ERAL1]]|0.534|
|[[:human genes:m:mrps34|MRPS34]]|0.532|
|[[:human genes:g:gfm1|GFM1]]|0.529|
|[[:human genes:c:coa3|COA3]]|0.528|
|[[:human genes:m:mrpl21|MRPL21]]|0.527|
|[[:human genes:m:mrps14|MRPS14]]|0.523|
|[[:human genes:m:mrps26|MRPS26]]|0.511|
|[[:human genes:g:gfm2|GFM2]]|0.51|
|[[:human genes:m:mrpl45|MRPL45]]|0.508|
|[[:human genes:y:yars2|YARS2]]|0.508|
|[[:human genes:p:pet112|PET112]]|0.504|
|[[:human genes:m:mrps2|MRPS2]]|0.502|
|[[:human genes:m:mrpl3|MRPL3]]|0.502|
|[[:human genes:f:fars2|FARS2]]|0.496|
|[[:human genes:t:tomm20|TOMM20]]|0.495|
|[[:human genes:m:mtrf1l|MTRF1L]]|0.491|
|[[:human genes:a:aars2|AARS2]]|0.491|
|[[:human genes:m:mrps25|MRPS25]]|0.491|
|[[:human genes:m:mars2|MARS2]]|0.49|
|[[:human genes:m:mrpl47|MRPL47]]|0.49|
|[[:human genes:e:ears2|EARS2]]|0.487|
|[[:human genes:m:mrps9|MRPS9]]|0.487|
|[[:human genes:f:ftsj2|FTSJ2]]|0.487|
|[[:human genes:m:mrps5|MRPS5]]|0.486|
|[[:human genes:m:mrps12|MRPS12]]|0.485|
|[[:human genes:t:trub2|TRUB2]]|0.485|
|[[:human genes:p:polg2|POLG2]]|0.484|
|[[:human genes:v:vars2|VARS2]]|0.479|
|[[:human genes:w:wbscr16|WBSCR16]]|0.479|
|[[:human genes:m:mrpl43|MRPL43]]|0.479|
|[[:human genes:c:cox11|COX11]]|0.478|
|[[:human genes:m:mtg2|MTG2]]|0.477|
|[[:human genes:m:mtg1|MTG1]]|0.477|
|[[:human genes:m:mrpl23|MRPL23]]|0.476|
|[[:human genes:m:mrpl15|MRPL15]]|0.475|
|[[:human genes:d:dars2|DARS2]]|0.473|
|[[:human genes:c:cox16|COX16]]|0.473|
|[[:human genes:m:mrpl18|MRPL18]]|0.473|
|[[:human genes:i:iba57|IBA57]]|0.472|
|[[:human genes:m:mtpap|MTPAP]]|0.472|
|[[:human genes:n:ndufaf3|NDUFAF3]]|0.471|
|[[:human genes:m:mrpl36|MRPL36]]|0.471|
|[[:human genes:m:mrps21|MRPS21]]|0.471|
|[[:human genes:t:tars2|TARS2]]|0.47|
|[[:human genes:m:mrp63|MRP63]]|0.47|
|[[:human genes:s:selrc1|SELRC1]]|0.466|
|[[:human genes:t:tfb1m|TFB1M]]|0.465|
|[[:human genes:l:lars2|LARS2]]|0.464|
|[[:human genes:m:mcat|MCAT]]|0.463|
|[[:human genes:m:mrpl35|MRPL35]]|0.461|
|[[:human genes:p:pet117|PET117]]|0.459|
|[[:human genes:p:ptcd3|PTCD3]]|0.459|
|[[:human genes:m:mrps18a|MRPS18A]]|0.457|
|[[:human genes:m:mrpl49|MRPL49]]|0.455|
|[[:human genes:c:c10orf2|C10orf2]]|0.451|
|[[:human genes:a:acad9|ACAD9]]|0.451|
|[[:human genes:m:mrpl12|MRPL12]]|0.451|
|[[:human genes:t:tufm|TUFM]]|0.451|
|[[:human genes:m:mrpl33|MRPL33]]|0.45|
|[[:human genes:h:hmgxb3|HMGXB3]]|0.448|
|[[:human genes:m:mrpl39|MRPL39]]|0.446|
|[[:human genes:m:mrpl44|MRPL44]]|0.445|
|[[:human genes:c:chchd1|CHCHD1]]|0.444|
|[[:human genes:m:mrpl28|MRPL28]]|0.443|
|[[:human genes:m:mrpl20|MRPL20]]|0.442|
|[[:human genes:a:atp5sl|ATP5SL]]|0.442|
|[[:human genes:n:ndufs2|NDUFS2]]|0.441|
|[[:human genes:t:tfb2m|TFB2M]]|0.441|
|[[:human genes:n:ndufc2|NDUFC2]]|0.441|
|[[:human genes:m:mrpl11|MRPL11]]|0.441|
|[[:human genes:c:cox7b|COX7B]]|0.441|
|[[:human genes:m:mrpl55|MRPL55]]|0.441|
|[[:human genes:m:mrpl42|MRPL42]]|0.439|
|[[:human genes:n:ndufaf7|NDUFAF7]]|0.439|
|[[:human genes:f:fastkd5|FASTKD5]]|0.438|
|[[:human genes:d:ddx28|DDX28]]|0.437|
|[[:human genes:s:supv3l1|SUPV3L1]]|0.436|
|[[:human genes:r:rpusd3|RPUSD3]]|0.435|
|[[:human genes:n:ndufa3|NDUFA3]]|0.435|
|[[:human genes:m:mrpl4|MRPL4]]|0.434|
|[[:human genes:n:ndufb11|NDUFB11]]|0.434|
|[[:human genes:r:rbfa|RBFA]]|0.432|
|[[:human genes:m:mipep|MIPEP]]|0.432|
|[[:human genes:h:hars2|HARS2]]|0.431|
|[[:human genes:n:ndufb9|NDUFB9]]|0.431|
|[[:human genes:p:pars2|PARS2]]|0.43|
|[[:human genes:m:mrpl53|MRPL53]]|0.43|
|[[:human genes:t:tefm|TEFM]]|0.429|
|[[:human genes:n:ndufa1|NDUFA1]]|0.427|
|[[:human genes:c:cars2|CARS2]]|0.425|
|[[:human genes:t:tfam|TFAM]]|0.425|
|[[:human genes:m:mrps11|MRPS11]]|0.425|
|[[:human genes:m:mrpl22|MRPL22]]|0.423|
|[[:human genes:n:nsun4|NSUN4]]|0.422|
|[[:human genes:m:mtfmt|MTFMT]]|0.421|
|[[:human genes:w:wars2|WARS2]]|0.42|
|[[:human genes:n:ndufa2|NDUFA2]]|0.42|
|[[:human genes:n:ndufaf5|NDUFAF5]]|0.42|
|[[:human genes:g:glrx5|GLRX5]]|0.42|
|[[:human genes:g:gtpbp6|GTPBP6]]|0.418|
|[[:human genes:p:polrmt|POLRMT]]|0.418|
|[[:human genes:m:mrpl17|MRPL17]]|0.418|
|[[:human genes:a:aifm1|AIFM1]]|0.416|
|[[:human genes:p:prepl|PREPL]]|0.416|
|[[:human genes:r:rnmtl1|RNMTL1]]|0.416|
|[[:human genes:k:kiaa0391|KIAA0391]]|0.416|
|[[:human genes:m:mrps35|MRPS35]]|0.415|
|[[:human genes:m:mrps7|MRPS7]]|0.415|
|[[:human genes:m:malsu1|MALSU1]]|0.414|
|[[:human genes:m:mrps18b|MRPS18B]]|0.414|
|[[:human genes:m:mrpl38|MRPL38]]|0.413|
|[[:human genes:m:mrpl37|MRPL37]]|0.413|
|[[:human genes:t:timm8b|TIMM8B]]|0.413|
|[[:human genes:g:gtpbp8|GTPBP8]]|0.412|
|[[:human genes:n:ndufb3|NDUFB3]]|0.411|
|[[:human genes:n:ndufb6|NDUFB6]]|0.411|
|[[:human genes:c:cox6c|COX6C]]|0.411|
|[[:human genes:b:bcs1l|BCS1L]]|0.41|
|[[:human genes:p:ptcd1|PTCD1]]|0.41|
|[[:human genes:p:pnpt1|PNPT1]]|0.41|
|[[:human genes:f:fastkd2|FASTKD2]]|0.407|
|[[:human genes:m:mterfd1|MTERFD1]]|0.406|
|[[:human genes:p:polg|POLG]]|0.405|
|[[:human genes:m:mrps10|MRPS10]]|0.405|
|[[:human genes:p:pdss1|PDSS1]]|0.403|
|[[:human genes:s:ssbp1|SSBP1]]|0.403|
|[[:human genes:c:coa6|COA6]]|0.402|
|[[:human genes:g:grsf1|GRSF1]]|0.402|
|[[:human genes:c:coq2|COQ2]]|0.4|
|[[:human genes:m:mtif2|MTIF2]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 47/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|1/28|
|blood|2/28|
|bone|1/26|
|breast|5/33|
|central nervous system|1/56|
|cervix|0/4|
|colorectal|3/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|1/16|
|kidney|2/21|
|liver|2/20|
|lung|6/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|2/24|
|peripheral nervous system|3/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|1/24|
|soft tissue|1/9|
|thyroid|0/2|
|upper aerodigestive|3/22|
|urinary tract|0/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1562
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.54 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MRPS22 Expression in NALM6 Cells: 5.54'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>