MRPS35 [The Human Chemical-Genetic Interaction Map Project]

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======= MRPS35 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MRPS35
  * **<color #00a2e8>Official Name</color>**: mitochondrial ribosomal protein S35
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=60488|60488]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P82673|P82673]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MRPS35&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MRPS35|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/611995|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|MRP-S28|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|mitochondrial small ribosomal subunit|
|DNA damage response, detection of DNA damage|
|mitochondrial translational termination|
|mitochondrial translational elongation|
|translational termination|
|mitochondrial translation|
|translational elongation|
|cellular protein complex disassembly|
|mitochondrial gene expression|
|structural constituent of ribosome|
|protein-containing complex disassembly|
|translation|
|mitochondrial inner membrane|
|cellular component disassembly|
|peptide biosynthetic process|
|amide biosynthetic process|
|peptide metabolic process|
|detection of stimulus|
|cellular response to DNA damage stimulus|
|cellular amide metabolic process|
|RNA binding|
|organonitrogen compound biosynthetic process|
|cellular nitrogen compound biosynthetic process|
|cellular response to stress|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|protein-containing complex subunit organization|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp438|NN-Diethyl-meta-toluamide 500μM R08 exp438]]|-1.72|
|[[:results:exp468|CB-5083 0.4μM R08 exp468]]|1.7|
|[[:results:exp352|Dexamethasone 0.006 to 0.015μM on day4 R07 exp352]]|1.71|
|[[:results:exp351|Dexamethasone 0.006μM R07 exp351]]|1.72|
|[[:results:exp46|HMS-I1 1μM R01 exp46]]|1.72|
|[[:results:exp346|CoCl2 18μM R07 exp346]]|1.83|
|[[:results:exp350|Deferoxamine 11μM R07 exp350]]|1.86|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|1.94|
|[[:results:exp48|Mubritinib 0.2μM R01 exp48]]|1.96|
|[[:results:exp393|Resminostat 0.5μM R07 exp393]]|2|
|[[:results:exp441|GSK-J4 1.5μM R08 exp441]]|2.01|
|[[:results:exp241|QNZ 0.01μM R05 exp241]]|2.06|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|2.14|
|[[:results:exp492|iCRT14 30μM R08 exp492]]|2.27|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|2.32|
|[[:results:exp380|NMS-873 0.07μM R07 exp380]]|2.35|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|2.57|
|[[:results:exp321|ABT-702 5μM plus Deferoxamine 11μM R07 exp321]]|2.74|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:m:mrps10|MRPS10]]|0.584|
|[[:human genes:m:mrps21|MRPS21]]|0.573|
|[[:human genes:p:pet112|PET112]]|0.566|
|[[:human genes:m:mrpl3|MRPL3]]|0.562|
|[[:human genes:m:mrps6|MRPS6]]|0.562|
|[[:human genes:m:mrpl23|MRPL23]]|0.558|
|[[:human genes:e:ears2|EARS2]]|0.557|
|[[:human genes:t:trub2|TRUB2]]|0.553|
|[[:human genes:m:mrpl21|MRPL21]]|0.553|
|[[:human genes:h:hsd17b10|HSD17B10]]|0.55|
|[[:human genes:n:nars2|NARS2]]|0.548|
|[[:human genes:d:dap3|DAP3]]|0.547|
|[[:human genes:p:pars2|PARS2]]|0.547|
|[[:human genes:f:ftsj2|FTSJ2]]|0.544|
|[[:human genes:t:tars2|TARS2]]|0.542|
|[[:human genes:m:mtg1|MTG1]]|0.542|
|[[:human genes:c:coa3|COA3]]|0.54|
|[[:human genes:m:mrpl18|MRPL18]]|0.535|
|[[:human genes:m:mrpl12|MRPL12]]|0.533|
|[[:human genes:y:yars2|YARS2]]|0.532|
|[[:human genes:m:mrps5|MRPS5]]|0.525|
|[[:human genes:m:mtif2|MTIF2]]|0.523|
|[[:human genes:m:mrps34|MRPS34]]|0.52|
|[[:human genes:f:fastkd5|FASTKD5]]|0.519|
|[[:human genes:s:selrc1|SELRC1]]|0.518|
|[[:human genes:m:mrps12|MRPS12]]|0.516|
|[[:human genes:m:mrps18a|MRPS18A]]|0.515|
|[[:human genes:r:rars2|RARS2]]|0.514|
|[[:human genes:v:vars2|VARS2]]|0.512|
|[[:human genes:m:mtg2|MTG2]]|0.512|
|[[:human genes:a:aars2|AARS2]]|0.511|
|[[:human genes:m:mrpl53|MRPL53]]|0.509|
|[[:human genes:p:pet117|PET117]]|0.509|
|[[:human genes:r:rpusd4|RPUSD4]]|0.508|
|[[:human genes:m:mettl17|METTL17]]|0.506|
|[[:human genes:m:mrps16|MRPS16]]|0.503|
|[[:human genes:q:qrsl1|QRSL1]]|0.503|
|[[:human genes:r:rnmtl1|RNMTL1]]|0.502|
|[[:human genes:h:hars2|HARS2]]|0.5|
|[[:human genes:i:ict1|ICT1]]|0.499|
|[[:human genes:c:coa6|COA6]]|0.497|
|[[:human genes:r:rbfa|RBFA]]|0.496|
|[[:human genes:h:hmgxb3|HMGXB3]]|0.496|
|[[:human genes:m:mrps25|MRPS25]]|0.495|
|[[:human genes:m:mrps7|MRPS7]]|0.494|
|[[:human genes:m:mrpl42|MRPL42]]|0.493|
|[[:human genes:m:mars2|MARS2]]|0.493|
|[[:human genes:g:gatc|GATC]]|0.492|
|[[:human genes:l:lars2|LARS2]]|0.49|
|[[:human genes:m:mrpl35|MRPL35]]|0.486|
|[[:human genes:m:mrpl55|MRPL55]]|0.484|
|[[:human genes:m:mrps27|MRPS27]]|0.482|
|[[:human genes:m:mrpl47|MRPL47]]|0.481|
|[[:human genes:g:gfm1|GFM1]]|0.479|
|[[:human genes:d:ddx28|DDX28]]|0.478|
|[[:human genes:m:mrpl4|MRPL4]]|0.472|
|[[:human genes:l:lrpprc|LRPPRC]]|0.471|
|[[:human genes:m:mrpl2|MRPL2]]|0.469|
|[[:human genes:a:acad9|ACAD9]]|0.469|
|[[:human genes:m:mrp63|MRP63]]|0.469|
|[[:human genes:k:kiaa0391|KIAA0391]]|0.469|
|[[:human genes:s:sco2|SCO2]]|0.466|
|[[:human genes:m:mrps26|MRPS26]]|0.464|
|[[:human genes:m:mrpl19|MRPL19]]|0.463|
|[[:human genes:n:ndufa3|NDUFA3]]|0.463|
|[[:human genes:w:wbscr16|WBSCR16]]|0.462|
|[[:human genes:f:fars2|FARS2]]|0.462|
|[[:human genes:m:mrps24|MRPS24]]|0.462|
|[[:human genes:g:gtpbp8|GTPBP8]]|0.458|
|[[:human genes:t:tfam|TFAM]]|0.457|
|[[:human genes:n:ndufb11|NDUFB11]]|0.455|
|[[:human genes:m:mterfd1|MTERFD1]]|0.455|
|[[:human genes:m:malsu1|MALSU1]]|0.454|
|[[:human genes:m:mrpl28|MRPL28]]|0.453|
|[[:human genes:g:gtpbp10|GTPBP10]]|0.451|
|[[:human genes:p:polg2|POLG2]]|0.451|
|[[:human genes:m:mrpl43|MRPL43]]|0.451|
|[[:human genes:m:mrpl13|MRPL13]]|0.449|
|[[:human genes:n:ndufc2|NDUFC2]]|0.448|
|[[:human genes:m:mrpl45|MRPL45]]|0.446|
|[[:human genes:m:mrpl17|MRPL17]]|0.444|
|[[:human genes:m:mrpl49|MRPL49]]|0.443|
|[[:human genes:c:cox6b1|COX6B1]]|0.442|
|[[:human genes:e:eral1|ERAL1]]|0.442|
|[[:human genes:c:cox11|COX11]]|0.441|
|[[:human genes:m:mrps2|MRPS2]]|0.439|
|[[:human genes:m:mtpap|MTPAP]]|0.439|
|[[:human genes:a:aurkaip1|AURKAIP1]]|0.433|
|[[:human genes:c:coq7|COQ7]]|0.433|
|[[:human genes:m:mcat|MCAT]]|0.432|
|[[:human genes:f:fastkd2|FASTKD2]]|0.43|
|[[:human genes:p:ptpmt1|PTPMT1]]|0.429|
|[[:human genes:n:ndufa1|NDUFA1]]|0.426|
|[[:human genes:p:ptcd1|PTCD1]]|0.426|
|[[:human genes:c:c12orf65|C12orf65]]|0.425|
|[[:human genes:m:mrpl37|MRPL37]]|0.424|
|[[:human genes:m:mipep|MIPEP]]|0.424|
|[[:human genes:c:cox16|COX16]]|0.423|
|[[:human genes:m:mterfd2|MTERFD2]]|0.422|
|[[:human genes:m:mrpl38|MRPL38]]|0.42|
|[[:human genes:n:ndufa2|NDUFA2]]|0.418|
|[[:human genes:r:rpusd3|RPUSD3]]|0.416|
|[[:human genes:m:mrpl20|MRPL20]]|0.416|
|[[:human genes:m:mrps22|MRPS22]]|0.415|
|[[:human genes:n:ndufaf5|NDUFAF5]]|0.414|
|[[:human genes:c:chchd1|CHCHD1]]|0.414|
|[[:human genes:c:coq4|COQ4]]|0.413|
|[[:human genes:n:nsun4|NSUN4]]|0.413|
|[[:human genes:s:sars2|SARS2]]|0.412|
|[[:human genes:c:cox7b|COX7B]]|0.411|
|[[:human genes:m:mrpl39|MRPL39]]|0.411|
|[[:human genes:g:gtpbp6|GTPBP6]]|0.411|
|[[:human genes:m:mrps14|MRPS14]]|0.41|
|[[:human genes:c:cox5b|COX5B]]|0.41|
|[[:human genes:c:cox4i1|COX4I1]]|0.41|
|[[:human genes:m:mrpl52|MRPL52]]|0.409|
|[[:human genes:t:tomm20|TOMM20]]|0.408|
|[[:human genes:m:mrpl46|MRPL46]]|0.408|
|[[:human genes:d:dars2|DARS2]]|0.407|
|[[:human genes:e:ecsit|ECSIT]]|0.407|
|[[:human genes:x:xpnpep3|XPNPEP3]]|0.406|
|[[:human genes:m:mtrf1l|MTRF1L]]|0.405|
|[[:human genes:m:mrpl1|MRPL1]]|0.401|
|[[:human genes:p:polrmt|POLRMT]]|0.4|
|[[:human genes:c:clpp|CLPP]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 19/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|1/28|
|bone|0/26|
|breast|1/33|
|central nervous system|1/56|
|cervix|1/4|
|colorectal|1/17|
|esophagus|1/13|
|fibroblast|0/1|
|gastric|1/16|
|kidney|1/21|
|liver|0/20|
|lung|3/75|
|lymphocyte|0/16|
|ovary|1/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|1/15|
|prostate|0/1|
|skin|1/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|1/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 615
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.74 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MRPS35 Expression in NALM6 Cells: 5.74'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>