MRPS7 [The Human Chemical-Genetic Interaction Map Project]

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======= MRPS7 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MRPS7
  * **<color #00a2e8>Official Name</color>**: mitochondrial ribosomal protein S7
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=51081|51081]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y2R9|Q9Y2R9]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MRPS7&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MRPS7|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/611974|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Ribosomal S7|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|ribosomal small subunit assembly|
|mitochondrial small ribosomal subunit|
|rRNA binding|
|ribosome assembly|
|ribosomal small subunit biogenesis|
|mitochondrial translational termination|
|mitochondrial translational elongation|
|translational termination|
|mitochondrial translation|
|translational elongation|
|cellular protein complex disassembly|
|mitochondrial gene expression|
|mRNA binding|
|structural constituent of ribosome|
|ribonucleoprotein complex assembly|
|protein-containing complex disassembly|
|ribonucleoprotein complex subunit organization|
|ribosome biogenesis|
|translation|
|mitochondrial inner membrane|
|cellular component disassembly|
|peptide biosynthetic process|
|ribonucleoprotein complex biogenesis|
|amide biosynthetic process|
|peptide metabolic process|
|organelle assembly|
|cellular amide metabolic process|
|cellular protein-containing complex assembly|
|RNA binding|
|organonitrogen compound biosynthetic process|
|protein-containing complex assembly|
|cellular nitrogen compound biosynthetic process|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|protein-containing complex subunit organization|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp502|Milciclib 2μM R08 exp502]]|1.73|
|[[:results:exp481|Ethambutol 25μM R08 exp481]]|1.74|
|[[:results:exp507|Monensin 0.3μM R08 exp507]]|1.79|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|1.81|
|[[:results:exp302|35°C R06 exp302]]|2.23|
|[[:results:exp147|Resveratrol 16μM R03 exp147]]|2.27|
|[[:results:exp321|ABT-702 5μM plus Deferoxamine 11μM R07 exp321]]|2.31|
|[[:results:exp346|CoCl2 18μM R07 exp346]]|2.36|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|2.55|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:d:dap3|DAP3]]|0.562|
|[[:human genes:m:mrps5|MRPS5]]|0.551|
|[[:human genes:m:mrpl23|MRPL23]]|0.534|
|[[:human genes:m:mrps9|MRPS9]]|0.529|
|[[:human genes:g:gfm1|GFM1]]|0.528|
|[[:human genes:v:vars2|VARS2]]|0.527|
|[[:human genes:r:rpusd4|RPUSD4]]|0.524|
|[[:human genes:p:pars2|PARS2]]|0.523|
|[[:human genes:m:mrps14|MRPS14]]|0.521|
|[[:human genes:m:mrpl3|MRPL3]]|0.519|
|[[:human genes:h:hsd17b10|HSD17B10]]|0.516|
|[[:human genes:m:mrps21|MRPS21]]|0.515|
|[[:human genes:n:nars2|NARS2]]|0.514|
|[[:human genes:m:mrp63|MRP63]]|0.512|
|[[:human genes:m:mrpl12|MRPL12]]|0.506|
|[[:human genes:m:mars2|MARS2]]|0.503|
|[[:human genes:t:tars2|TARS2]]|0.503|
|[[:human genes:q:qrsl1|QRSL1]]|0.503|
|[[:human genes:m:mrpl53|MRPL53]]|0.502|
|[[:human genes:m:mrps16|MRPS16]]|0.501|
|[[:human genes:m:mrps25|MRPS25]]|0.5|
|[[:human genes:m:mrpl21|MRPL21]]|0.5|
|[[:human genes:m:mrpl45|MRPL45]]|0.494|
|[[:human genes:m:mrps35|MRPS35]]|0.494|
|[[:human genes:f:fars2|FARS2]]|0.494|
|[[:human genes:m:mrps23|MRPS23]]|0.493|
|[[:human genes:m:mrpl20|MRPL20]]|0.493|
|[[:human genes:h:hars2|HARS2]]|0.491|
|[[:human genes:m:mrpl47|MRPL47]]|0.488|
|[[:human genes:n:ndufa3|NDUFA3]]|0.487|
|[[:human genes:m:mrpl18|MRPL18]]|0.482|
|[[:human genes:d:dars2|DARS2]]|0.479|
|[[:human genes:f:ftsj2|FTSJ2]]|0.479|
|[[:human genes:y:yars2|YARS2]]|0.479|
|[[:human genes:l:lars2|LARS2]]|0.478|
|[[:human genes:m:mrps26|MRPS26]]|0.476|
|[[:human genes:m:mrps6|MRPS6]]|0.476|
|[[:human genes:m:mrps18a|MRPS18A]]|0.475|
|[[:human genes:r:rpusd3|RPUSD3]]|0.473|
|[[:human genes:m:mrps34|MRPS34]]|0.472|
|[[:human genes:t:trub2|TRUB2]]|0.466|
|[[:human genes:p:pet112|PET112]]|0.465|
|[[:human genes:m:mrpl43|MRPL43]]|0.464|
|[[:human genes:e:ears2|EARS2]]|0.461|
|[[:human genes:s:ssbp1|SSBP1]]|0.459|
|[[:human genes:m:mtg2|MTG2]]|0.458|
|[[:human genes:c:c10orf2|C10orf2]]|0.457|
|[[:human genes:p:pnpt1|PNPT1]]|0.457|
|[[:human genes:h:hmgxb3|HMGXB3]]|0.455|
|[[:human genes:m:mrps2|MRPS2]]|0.455|
|[[:human genes:g:gtpbp10|GTPBP10]]|0.454|
|[[:human genes:a:aars2|AARS2]]|0.454|
|[[:human genes:r:rars2|RARS2]]|0.453|
|[[:human genes:s:selrc1|SELRC1]]|0.453|
|[[:human genes:k:kiaa0391|KIAA0391]]|0.451|
|[[:human genes:r:rbfa|RBFA]]|0.45|
|[[:human genes:t:tfam|TFAM]]|0.449|
|[[:human genes:m:mrpl17|MRPL17]]|0.448|
|[[:human genes:m:mrps24|MRPS24]]|0.448|
|[[:human genes:c:cox16|COX16]]|0.448|
|[[:human genes:g:gfm2|GFM2]]|0.447|
|[[:human genes:m:mettl17|METTL17]]|0.447|
|[[:human genes:m:mrpl33|MRPL33]]|0.447|
|[[:human genes:c:coa3|COA3]]|0.447|
|[[:human genes:m:mrpl52|MRPL52]]|0.446|
|[[:human genes:t:tefm|TEFM]]|0.445|
|[[:human genes:f:fastkd5|FASTKD5]]|0.443|
|[[:human genes:n:ndufb11|NDUFB11]]|0.443|
|[[:human genes:m:mrps12|MRPS12]]|0.441|
|[[:human genes:s:sars2|SARS2]]|0.44|
|[[:human genes:w:wbscr16|WBSCR16]]|0.44|
|[[:human genes:m:mrpl13|MRPL13]]|0.44|
|[[:human genes:m:mrpl39|MRPL39]]|0.439|
|[[:human genes:n:ndufc2|NDUFC2]]|0.437|
|[[:human genes:t:tufm|TUFM]]|0.435|
|[[:human genes:m:mrpl51|MRPL51]]|0.435|
|[[:human genes:r:rtn4ip1|RTN4IP1]]|0.432|
|[[:human genes:s:sco2|SCO2]]|0.431|
|[[:human genes:c:cox7b|COX7B]]|0.431|
|[[:human genes:e:eral1|ERAL1]]|0.43|
|[[:human genes:m:mrpl15|MRPL15]]|0.43|
|[[:human genes:t:tfb1m|TFB1M]]|0.427|
|[[:human genes:c:c12orf65|C12orf65]]|0.427|
|[[:human genes:r:rnmtl1|RNMTL1]]|0.425|
|[[:human genes:c:coa6|COA6]]|0.425|
|[[:human genes:m:mrpl42|MRPL42]]|0.425|
|[[:human genes:c:coq2|COQ2]]|0.425|
|[[:human genes:t:tfb2m|TFB2M]]|0.422|
|[[:human genes:p:pdss1|PDSS1]]|0.421|
|[[:human genes:m:mrps33|MRPS33]]|0.42|
|[[:human genes:p:ptcd3|PTCD3]]|0.417|
|[[:human genes:m:mrpl46|MRPL46]]|0.417|
|[[:human genes:p:polg2|POLG2]]|0.417|
|[[:human genes:n:ndufa1|NDUFA1]]|0.416|
|[[:human genes:m:mrps22|MRPS22]]|0.415|
|[[:human genes:m:mrps27|MRPS27]]|0.415|
|[[:human genes:s:supv3l1|SUPV3L1]]|0.414|
|[[:human genes:p:pet117|PET117]]|0.41|
|[[:human genes:g:gatc|GATC]]|0.408|
|[[:human genes:c:cars2|CARS2]]|0.407|
|[[:human genes:m:mrps10|MRPS10]]|0.407|
|[[:human genes:m:mrpl22|MRPL22]]|0.406|
|[[:human genes:n:ndufb4|NDUFB4]]|0.405|
|[[:human genes:g:gtpbp8|GTPBP8]]|0.404|
|[[:human genes:m:mterfd2|MTERFD2]]|0.403|
|[[:human genes:m:mrpl28|MRPL28]]|0.403|
|[[:human genes:m:mtif2|MTIF2]]|0.401|
|[[:human genes:m:mrps17|MRPS17]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 27/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|1/28|
|blood|0/28|
|bone|0/26|
|breast|4/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|1/21|
|liver|0/20|
|lung|4/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|3/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|1/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|2/22|
|urinary tract|0/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2097
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.06 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MRPS7 Expression in NALM6 Cells: 6.06'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>