MST4 [The Human Chemical-Genetic Interaction Map Project]

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======= MST4 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: STK26
  * **<color #00a2e8>Official Name</color>**: serine/threonine kinase 26
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=51765|51765]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9P289|Q9P289]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MST4&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MST4|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/300547|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The product of this gene is a member of the GCK group III family of kinases, which are a subset of the Ste20-like kinases. The encoded protein contains an amino-terminal kinase domain, and a carboxy-terminal regulatory domain that mediates homodimerization. The protein kinase localizes to the Golgi apparatus and is specifically activated by binding to the Golgi matrix protein GM130. It is also cleaved by caspase-3 in vitro, and may function in the apoptotic pathway. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Mediator of cell growth (PubMed:11641781, PubMed:17360971). Modulates apoptosis (PubMed:11641781, PubMed:17360971). In association with STK24 negatively regulates Golgi reorientation in polarized cell migration upon RHO activation (PubMed:27807006). {ECO:0000269|PubMed:11641781, ECO:0000269|PubMed:17360971, ECO:0000269|PubMed:27807006}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Pkinase|
|Pkinase Tyr|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|microvillus assembly|
|Golgi-associated vesicle|
|microvillus organization|
|regulation of hydrogen peroxide-induced cell death|
|vesicle membrane|
|regulation of response to reactive oxygen species|
|regulation of cellular response to drug|
|cell periphery|
|regulation of oxidative stress-induced cell death|
|regulation of cellular response to oxidative stress|
|regulation of response to oxidative stress|
|regulation of response to drug|
|response to hydrogen peroxide|
|stress-activated protein kinase signaling cascade|
|cellular response to starvation|
|protein autophosphorylation|
|response to starvation|
|response to reactive oxygen species|
|magnesium ion binding|
|cellular response to nutrient levels|
|protein kinase activity|
|negative regulation of cell migration|
|cellular response to extracellular stimulus|
|negative regulation of cell motility|
|response to antibiotic|
|negative regulation of cellular component movement|
|apical plasma membrane|
|negative regulation of locomotion|
|activation of protein kinase activity|
|cellular response to external stimulus|
|protein serine/threonine kinase activity|
|MAPK cascade|
|response to oxidative stress|
|signal transduction by protein phosphorylation|
|plasma membrane bounded cell projection assembly|
|cell projection assembly|
|neuron projection morphogenesis|
|plasma membrane bounded cell projection morphogenesis|
|cell projection morphogenesis|
|response to nutrient levels|
|response to toxic substance|
|cell part morphogenesis|
|response to extracellular stimulus|
|positive regulation of protein kinase activity|
|response to inorganic substance|
|positive regulation of kinase activity|
|Golgi membrane|
|positive regulation of transferase activity|
|neuron projection development|
|perinuclear region of cytoplasm|
|cell morphogenesis|
|regulation of cellular response to stress|
|regulation of protein kinase activity|
|neuron development|
|cellular component morphogenesis|
|regulation of cell migration|
|regulation of kinase activity|
|protein homodimerization activity|
|regulation of cell motility|
|apoptotic process|
|protein phosphorylation|
|regulation of transferase activity|
|regulation of locomotion|
|Golgi apparatus|
|regulation of cellular component movement|
|neuron differentiation|
|positive regulation of protein phosphorylation|
|response to drug|
|programmed cell death|
|positive regulation of phosphorylation|
|identical protein binding|
|cell death|
|plasma membrane bounded cell projection organization|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|cell projection organization|
|positive regulation of protein modification process|
|phosphorylation|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|regulation of response to stress|
|ATP binding|
|generation of neurons|
|regulation of apoptotic process|
|response to oxygen-containing compound|
|regulation of programmed cell death|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|neurogenesis|
|cell development|
|regulation of cell death|
|intracellular signal transduction|
|cellular response to stress|
|positive regulation of protein metabolic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of protein modification process|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp332|Adefovir 20μM R07 exp332]]|-2.38|
|[[:results:exp473|Cincreasin 100μM R08 exp473]]|1.95|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/694
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/26|
|bone|0/26|
|breast|0/30|
|central nervous system|0/49|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/11|
|fibroblast|0/1|
|gastric|0/14|
|kidney|0/18|
|liver|0/19|
|lung|0/72|
|lymphocyte|0/16|
|ovary|0/25|
|pancreas|0/22|
|peripheral nervous system|0/15|
|plasma cell|0/12|
|prostate|0/1|
|skin|0/20|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/28|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 18906
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.21 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MST4 Expression in NALM6 Cells: 6.21'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>