MSTO1 [The Human Chemical-Genetic Interaction Map Project]

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======= MSTO1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MSTO1
  * **<color #00a2e8>Official Name</color>**: misato mitochondrial distribution and morphology regulator 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=55154|55154]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9BUK6|Q9BUK6]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MSTO1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MSTO1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/617619|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Misat Myo SegII|
|Tubulin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|mitochondrion distribution|
|mitochondrial genome maintenance|
|mitotic spindle assembly|
|mitochondrion localization|
|mitotic spindle organization|
|spindle assembly|
|microtubule cytoskeleton organization involved in mitosis|
|mitotic sister chromatid segregation|
|sister chromatid segregation|
|mitotic nuclear division|
|spindle organization|
|mitochondrial outer membrane|
|nuclear chromosome segregation|
|chromosome segregation|
|nuclear division|
|organelle fission|
|mitochondrion organization|
|microtubule cytoskeleton organization|
|organelle localization|
|mitotic cell cycle process|
|microtubule-based process|
|mitotic cell cycle|
|organelle assembly|
|molecular function|
|cell cycle process|
|chromosome organization|
|cytoskeleton organization|
|cell cycle|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp237|NN-Diethyl-meta-toluamide 100μM R05 exp237]]|-2.09|
|[[:results:exp454|Bafilomycin-A1 0.009μM R08 exp454]]|-1.97|
|[[:results:exp311|2-Methoxyestradiol 0.55 to 0.75μM  on day4 R07 exp311]]|-1.84|
|[[:results:exp130|JQ1 0.01μM R03 exp130]]|-1.82|
|[[:results:exp460|BML-284 0.09μM R08 exp460]]|-1.78|
|[[:results:exp190|Vincristine 0.0005μM R04 exp190]]|-1.74|
|[[:results:exp275|Citral 75μM R06 exp275]]|1.72|
|[[:results:exp441|GSK-J4 1.5μM R08 exp441]]|1.72|
|[[:results:exp478|Doxorubicin 0.02μM R08 exp478]]|1.81|
|[[:results:exp269|Bisphenol A 100μM R06 exp269]]|2.12|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rpp21|RPP21]]|0.535|
|[[:human genes:g:gemin8|GEMIN8]]|0.529|
|[[:human genes:t:ten1|TEN1]]|0.522|
|[[:human genes:d:dhrsx|DHRSX]]|0.504|
|[[:human genes:g:gemin7|GEMIN7]]|0.494|
|[[:human genes:t:thg1l|THG1L]]|0.473|
|[[:human genes:t:trmt61a|TRMT61A]]|0.466|
|[[:human genes:g:gtf3c6|GTF3C6]]|0.465|
|[[:human genes:c:c15orf41|C15orf41]]|0.465|
|[[:human genes:g:gemin6|GEMIN6]]|0.464|
|[[:human genes:v:vezt|VEZT]]|0.46|
|[[:human genes:p:ppcs|PPCS]]|0.459|
|[[:human genes:u:urm1|URM1]]|0.459|
|[[:human genes:e:elp6|ELP6]]|0.454|
|[[:human genes:p:ppp6c|PPP6C]]|0.445|
|[[:human genes:t:tamm41|TAMM41]]|0.444|
|[[:human genes:p:ppcdc|PPCDC]]|0.44|
|[[:human genes:s:sars2|SARS2]]|0.44|
|[[:human genes:a:adsl|ADSL]]|0.439|
|[[:human genes:m:mocs3|MOCS3]]|0.439|
|[[:human genes:e:eftud1|EFTUD1]]|0.438|
|[[:human genes:p:pgm3|PGM3]]|0.437|
|[[:human genes:e:elp3|ELP3]]|0.437|
|[[:human genes:a:alg1|ALG1]]|0.434|
|[[:human genes:c:ctu1|CTU1]]|0.434|
|[[:human genes:p:pmvk|PMVK]]|0.432|
|[[:human genes:a:alg13|ALG13]]|0.431|
|[[:human genes:d:dr1|DR1]]|0.43|
|[[:human genes:s:ssb|SSB]]|0.424|
|[[:human genes:u:uap1|UAP1]]|0.423|
|[[:human genes:p:ptar1|PTAR1]]|0.422|
|[[:human genes:p:pdcd5|PDCD5]]|0.42|
|[[:human genes:z:zrsr2|ZRSR2]]|0.418|
|[[:human genes:d:dph1|DPH1]]|0.417|
|[[:human genes:r:rft1|RFT1]]|0.414|
|[[:human genes:b:bcs1l|BCS1L]]|0.41|
|[[:human genes:r:rpia|RPIA]]|0.41|
|[[:human genes:f:fancc|FANCC]]|0.409|
|[[:human genes:m:mbtps2|MBTPS2]]|0.408|
|[[:human genes:t:txnl4b|TXNL4B]]|0.407|
|[[:human genes:e:elp2|ELP2]]|0.405|
|[[:human genes:t:tbcb|TBCB]]|0.404|
|[[:human genes:a:atxn10|ATXN10]]|0.402|
|[[:human genes:n:nhp2|NHP2]]|0.4|
|[[:human genes:d:dolk|DOLK]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 295/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|1/1|
|bile duct|12/28|
|blood|16/28|
|bone|4/26|
|breast|11/33|
|central nervous system|30/56|
|cervix|1/4|
|colorectal|5/17|
|esophagus|3/13|
|fibroblast|1/1|
|gastric|6/16|
|kidney|5/21|
|liver|10/20|
|lung|27/75|
|lymphocyte|4/16|
|ovary|13/26|
|pancreas|9/24|
|peripheral nervous system|4/16|
|plasma cell|5/15|
|prostate|1/1|
|skin|8/24|
|soft tissue|6/9|
|thyroid|2/2|
|upper aerodigestive|9/22|
|urinary tract|16/29|
|uterus|2/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 997
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.87 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MSTO1 Expression in NALM6 Cells: 6.87'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>