MT1A [The Human Chemical-Genetic Interaction Map Project]

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======= MT1A =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MT1A
  * **<color #00a2e8>Official Name</color>**: metallothionein 1A
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4489|4489]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P04731|P04731]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MT1A&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MT1A|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/156350|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Metallothio|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|detoxification of copper ion|
|stress response to copper ion|
|stress response to metal ion|
|detoxification of inorganic compound|
|cellular response to zinc ion|
|cellular response to copper ion|
|cellular zinc ion homeostasis|
|zinc ion homeostasis|
|cellular response to cadmium ion|
|response to copper ion|
|response to zinc ion|
|response to cadmium ion|
|cellular transition metal ion homeostasis|
|detoxification|
|transition metal ion homeostasis|
|cellular response to metal ion|
|cellular response to inorganic substance|
|negative regulation of growth|
|response to metal ion|
|cellular divalent inorganic cation homeostasis|
|divalent inorganic cation homeostasis|
|response to toxic substance|
|response to inorganic substance|
|cellular metal ion homeostasis|
|metal ion homeostasis|
|cellular cation homeostasis|
|cellular ion homeostasis|
|regulation of growth|
|perinuclear region of cytoplasm|
|cation homeostasis|
|inorganic ion homeostasis|
|cellular chemical homeostasis|
|ion homeostasis|
|zinc ion binding|
|cellular homeostasis|
|chemical homeostasis|
|homeostatic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp438|NN-Diethyl-meta-toluamide 500μM R08 exp438]]|-2.01|
|[[:results:exp1|5-Fluorouracil 2μM R00 exp1]]|-1.89|
|[[:results:exp141|Nifurtimox 1μM R03 exp141]]|-1.72|
|[[:results:exp67|BVD-523 15μM R02 exp67]]|1.78|
|[[:results:exp474|CR131-b 0.005μM R08 exp474]]|1.79|
|[[:results:exp525|Sulforaphane 9μM R08 exp525]]|2.53|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4140
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.14 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MT1A Expression in NALM6 Cells: 2.14'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>