MT1E [The Human Chemical-Genetic Interaction Map Project]

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======= MT1E =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MT1E
  * **<color #00a2e8>Official Name</color>**: metallothionein 1E
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4493|4493]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P04732|P04732]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MT1E&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MT1E|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/156351|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Metallothio|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|detoxification of copper ion|
|stress response to copper ion|
|stress response to metal ion|
|detoxification of inorganic compound|
|cellular response to zinc ion|
|cellular response to copper ion|
|cellular zinc ion homeostasis|
|zinc ion homeostasis|
|cellular response to cadmium ion|
|response to copper ion|
|response to zinc ion|
|response to cadmium ion|
|cellular transition metal ion homeostasis|
|detoxification|
|transition metal ion homeostasis|
|cellular response to metal ion|
|cellular response to inorganic substance|
|negative regulation of growth|
|response to metal ion|
|cellular divalent inorganic cation homeostasis|
|divalent inorganic cation homeostasis|
|response to toxic substance|
|response to inorganic substance|
|cellular metal ion homeostasis|
|metal ion homeostasis|
|cellular cation homeostasis|
|cellular ion homeostasis|
|regulation of growth|
|perinuclear region of cytoplasm|
|cation homeostasis|
|inorganic ion homeostasis|
|cellular chemical homeostasis|
|ion homeostasis|
|zinc ion binding|
|cellular homeostasis|
|chemical homeostasis|
|homeostatic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp249|Vinorelbine 0.001μM R05 exp249]]|1.7|
|[[:results:exp61|YM155 0.0002μM R01 exp61]]|1.7|
|[[:results:exp58|UM131593 0.1μM R01 exp58]]|1.83|
|[[:results:exp49|NFN1 0.1μM R01 exp49]]|2.02|
|[[:results:exp40|2-Methoxyestradiol 0.2μM R01 exp40]]|2.05|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:c:chd4|CHD4]]|0.607|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.596|
|[[:human genes:v:vasn|VASN]]|0.585|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.581|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.571|
|[[:human genes:p:psmd3|PSMD3]]|0.569|
|[[:human genes:c:copg1|COPG1]]|0.562|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.558|
|[[:human genes:t:tceb3c|TCEB3C]]|0.558|
|[[:human genes:c:cbwd3|CBWD3]]|0.557|
|[[:human genes:c:cbwd5|CBWD5]]|0.555|
|[[:human genes:o:orc1|ORC1]]|0.553|
|[[:human genes:p:psmd11|PSMD11]]|0.552|
|[[:human genes:t:tfip11|TFIP11]]|0.544|
|[[:human genes:n:nupl1|NUPL1]]|0.544|
|[[:human genes:s:snrpa1|SNRPA1]]|0.544|
|[[:human genes:c:c14orf93|C14orf93]]|0.544|
|[[:human genes:l:lrr1|LRR1]]|0.54|
|[[:human genes:s:syt9|SYT9]]|0.54|
|[[:human genes:p:psmd1|PSMD1]]|0.539|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.539|
|[[:human genes:r:rad21|RAD21]]|0.539|
|[[:human genes:s:slc4a1|SLC4A1]]|0.534|
|[[:human genes:c:ccna2|CCNA2]]|0.533|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.526|
|[[:human genes:p:pan3|PAN3]]|0.524|
|[[:human genes:c:cbwd6|CBWD6]]|0.524|
|[[:human genes:r:rps19|RPS19]]|0.522|
|[[:human genes:n:npipb5|NPIPB5]]|0.521|
|[[:human genes:d:ddtl|DDTL]]|0.521|
|[[:human genes:p:polr2j3|POLR2J3]]|0.52|
|[[:human genes:p:plk1|PLK1]]|0.52|
|[[:human genes:p:psmb4|PSMB4]]|0.517|
|[[:human genes:p:psma6|PSMA6]]|0.516|
|[[:human genes:t:tp53tg3b|TP53TG3B]]|0.515|
|[[:human genes:t:tp53tg3|TP53TG3]]|0.514|
|[[:human genes:t:tp53tg3c|TP53TG3C]]|0.512|
|[[:human genes:p:psmb2|PSMB2]]|0.51|
|[[:human genes:p:psma7|PSMA7]]|0.51|
|[[:human genes:o:orc6|ORC6]]|0.509|
|[[:human genes:r:rps2|RPS2]]|0.509|
|[[:human genes:n:narfl|NARFL]]|0.508|
|[[:human genes:a:aqr|AQR]]|0.506|
|[[:human genes:c:cdc73|CDC73]]|0.506|
|[[:human genes:s:s1pr4|S1PR4]]|0.505|
|[[:human genes:p:psmc6|PSMC6]]|0.504|
|[[:human genes:u:upf1|UPF1]]|0.503|
|[[:human genes:d:dtl|DTL]]|0.502|
|[[:human genes:i:igfn1|IGFN1]]|0.501|
|[[:human genes:t:tbc1d3i|TBC1D3I]]|0.501|
|[[:human genes:t:tbc1d3e|TBC1D3E]]|0.501|
|[[:human genes:t:tbc1d3l|TBC1D3L]]|0.5|
|[[:human genes:t:tbc1d3k|TBC1D3K]]|0.5|
|[[:human genes:m:myo1h|MYO1H]]|0.497|
|[[:human genes:c:cope|COPE]]|0.495|
|[[:human genes:c:chmp2a|CHMP2A]]|0.492|
|[[:human genes:a:atp6v1c1|ATP6V1C1]]|0.491|
|[[:human genes:c:cdc6|CDC6]]|0.49|
|[[:human genes:l:loc643669|LOC643669]]|0.49|
|[[:human genes:h:hist2h3c|HIST2H3C]]|0.488|
|[[:human genes:h:hist2h3a|HIST2H3A]]|0.488|
|[[:human genes:c:copb1|COPB1]]|0.487|
|[[:human genes:g:golga6l3|GOLGA6L3]]|0.487|
|[[:human genes:m:madcam1|MADCAM1]]|0.486|
|[[:human genes:e:exosc5|EXOSC5]]|0.486|
|[[:human genes:s:supt6h|SUPT6H]]|0.486|
|[[:human genes:k:kctd17|KCTD17]]|0.484|
|[[:human genes:n:nup160|NUP160]]|0.482|
|[[:human genes:t:tspy8|TSPY8]]|0.481|
|[[:human genes:c:c2orf27b|C2orf27B]]|0.48|
|[[:human genes:c:ctr9|CTR9]]|0.479|
|[[:human genes:n:nup54|NUP54]]|0.479|
|[[:human genes:r:rps12|RPS12]]|0.479|
|[[:human genes:t:tbc1d3c|TBC1D3C]]|0.479|
|[[:human genes:p:polr1a|POLR1A]]|0.479|
|[[:human genes:z:znf830|ZNF830]]|0.478|
|[[:human genes:s:ssh2|SSH2]]|0.477|
|[[:human genes:s:sf3a3|SF3A3]]|0.476|
|[[:human genes:a:ankle1|ANKLE1]]|0.476|
|[[:human genes:s:supt5h|SUPT5H]]|0.475|
|[[:human genes:t:tbc1d3|TBC1D3]]|0.475|
|[[:human genes:s:scaf1|SCAF1]]|0.474|
|[[:human genes:p:pole|POLE]]|0.474|
|[[:human genes:c:ccdc116|CCDC116]]|0.473|
|[[:human genes:p:psmb1|PSMB1]]|0.473|
|[[:human genes:a:acsf2|ACSF2]]|0.473|
|[[:human genes:c:copa|COPA]]|0.472|
|[[:human genes:p:pigs|PIGS]]|0.472|
|[[:human genes:d:ddx56|DDX56]]|0.472|
|[[:human genes:p:paf1|PAF1]]|0.472|
|[[:human genes:x:xylt2|XYLT2]]|0.471|
|[[:human genes:c:cactin|CACTIN]]|0.47|
|[[:human genes:m:mdm2|MDM2]]|0.47|
|[[:human genes:t:ticrr|TICRR]]|0.47|
|[[:human genes:t:twistnb|TWISTNB]]|0.469|
|[[:human genes:t:tsg101|TSG101]]|0.467|
|[[:human genes:f:fam25b|FAM25B]]|0.467|
|[[:human genes:t:tuba8|TUBA8]]|0.467|
|[[:human genes:r:rad51|RAD51]]|0.467|
|[[:human genes:p:pan2|PAN2]]|0.467|
|[[:human genes:a:atxn1|ATXN1]]|0.466|
|[[:human genes:g:golga6l6|GOLGA6L6]]|0.465|
|[[:human genes:f:fcn2|FCN2]]|0.465|
|[[:human genes:c:cep192|CEP192]]|0.465|
|[[:human genes:r:rrp15|RRP15]]|0.464|
|[[:human genes:c:cmya5|CMYA5]]|0.464|
|[[:human genes:n:nop16|NOP16]]|0.463|
|[[:human genes:r:rbm39|RBM39]]|0.462|
|[[:human genes:d:dock6|DOCK6]]|0.462|
|[[:human genes:c:cdc45|CDC45]]|0.462|
|[[:human genes:p:psmd14|PSMD14]]|0.462|
|[[:human genes:i:ik|IK]]|0.461|
|[[:human genes:t:tyms|TYMS]]|0.461|
|[[:human genes:u:ubap1|UBAP1]]|0.461|
|[[:human genes:p:polr2f|POLR2F]]|0.46|
|[[:human genes:p:psmd2|PSMD2]]|0.46|
|[[:human genes:r:rfc1|RFC1]]|0.46|
|[[:human genes:s:stil|STIL]]|0.46|
|[[:human genes:g:gid4|GID4]]|0.459|
|[[:human genes:u:utp3|UTP3]]|0.459|
|[[:human genes:p:psmc2|PSMC2]]|0.458|
|[[:human genes:c:cgb2|CGB2]]|0.457|
|[[:human genes:p:pwp2|PWP2]]|0.456|
|[[:human genes:r:rplp1|RPLP1]]|0.456|
|[[:human genes:z:zfand5|ZFAND5]]|0.455|
|[[:human genes:a:aamp|AAMP]]|0.454|
|[[:human genes:p:prkcz|PRKCZ]]|0.454|
|[[:human genes:r:rrn3|RRN3]]|0.454|
|[[:human genes:r:rplp2|RPLP2]]|0.454|
|[[:human genes:c:cdca3|CDCA3]]|0.453|
|[[:human genes:p:prim1|PRIM1]]|0.453|
|[[:human genes:r:rpsa|RPSA]]|0.453|
|[[:human genes:u:uqcrh|UQCRH]]|0.453|
|[[:human genes:p:pla2g4f|PLA2G4F]]|0.451|
|[[:human genes:r:rpl35|RPL35]]|0.451|
|[[:human genes:p:psmc5|PSMC5]]|0.451|
|[[:human genes:c:chaf1a|CHAF1A]]|0.45|
|[[:human genes:t:tspy1|TSPY1]]|0.45|
|[[:human genes:b:bysl|BYSL]]|0.45|
|[[:human genes:r:rpl26|RPL26]]|0.448|
|[[:human genes:f:fam231c|FAM231C]]|0.448|
|[[:human genes:f:fam231a|FAM231A]]|0.447|
|[[:human genes:h:hap1|HAP1]]|0.446|
|[[:human genes:d:disp2|DISP2]]|0.446|
|[[:human genes:e:exosc6|EXOSC6]]|0.446|
|[[:human genes:p:pola1|POLA1]]|0.446|
|[[:human genes:e:eif4a3|EIF4A3]]|0.446|
|[[:human genes:n:nbpf10|NBPF10]]|0.445|
|[[:human genes:g:golga8o|GOLGA8O]]|0.445|
|[[:human genes:c:ccdc94|CCDC94]]|0.444|
|[[:human genes:p:pola2|POLA2]]|0.444|
|[[:human genes:c:cebpz|CEBPZ]]|0.443|
|[[:human genes:s:smg1|SMG1]]|0.443|
|[[:human genes:d:dhx38|DHX38]]|0.443|
|[[:human genes:f:fam160a1|FAM160A1]]|0.443|
|[[:human genes:c:ccdc64b|CCDC64B]]|0.443|
|[[:human genes:e:exosc9|EXOSC9]]|0.442|
|[[:human genes:c:ckap5|CKAP5]]|0.442|
|[[:human genes:r:rps9|RPS9]]|0.441|
|[[:human genes:d:ddt|DDT]]|0.441|
|[[:human genes:k:kpnb1|KPNB1]]|0.44|
|[[:human genes:w:wdr87|WDR87]]|0.439|
|[[:human genes:z:znf106|ZNF106]]|0.438|
|[[:human genes:o:ogfr|OGFR]]|0.437|
|[[:human genes:c:cdt1|CDT1]]|0.437|
|[[:human genes:r:rnf121|RNF121]]|0.437|
|[[:human genes:n:nuf2|NUF2]]|0.437|
|[[:human genes:g:golga6l4|GOLGA6L4]]|0.436|
|[[:human genes:p:psmc1|PSMC1]]|0.435|
|[[:human genes:p:parp3|PARP3]]|0.435|
|[[:human genes:s:sec13|SEC13]]|0.435|
|[[:human genes:n:nol8|NOL8]]|0.435|
|[[:human genes:p:pcf11|PCF11]]|0.435|
|[[:human genes:n:nsf|NSF]]|0.435|
|[[:human genes:t:traip|TRAIP]]|0.435|
|[[:human genes:m:med17|MED17]]|0.434|
|[[:human genes:a:ahctf1|AHCTF1]]|0.434|
|[[:human genes:e:exd1|EXD1]]|0.433|
|[[:human genes:i:iscu|ISCU]]|0.433|
|[[:human genes:g:gar1|GAR1]]|0.433|
|[[:human genes:a:arcn1|ARCN1]]|0.432|
|[[:human genes:p:plk4|PLK4]]|0.43|
|[[:human genes:s:smg7|SMG7]]|0.43|
|[[:human genes:h:hist1h2be|HIST1H2BE]]|0.429|
|[[:human genes:p:psmd6|PSMD6]]|0.429|
|[[:human genes:p:psmd7|PSMD7]]|0.429|
|[[:human genes:t:terf2|TERF2]]|0.428|
|[[:human genes:f:fbxw9|FBXW9]]|0.427|
|[[:human genes:t:tp53tg3d|TP53TG3D]]|0.427|
|[[:human genes:c:cnpy3|CNPY3]]|0.427|
|[[:human genes:m:med14|MED14]]|0.426|
|[[:human genes:c:copb2|COPB2]]|0.425|
|[[:human genes:s:smg5|SMG5]]|0.425|
|[[:human genes:s:sf3a1|SF3A1]]|0.425|
|[[:human genes:r:rbbp5|RBBP5]]|0.424|
|[[:human genes:a:atp13a1|ATP13A1]]|0.423|
|[[:human genes:r:rpl30|RPL30]]|0.423|
|[[:human genes:n:nup205|NUP205]]|0.423|
|[[:human genes:r:rps19bp1|RPS19BP1]]|0.422|
|[[:human genes:a:atp6v1a|ATP6V1A]]|0.422|
|[[:human genes:o:osbp|OSBP]]|0.421|
|[[:human genes:h:hinfp|HINFP]]|0.421|
|[[:human genes:g:gprin2|GPRIN2]]|0.42|
|[[:human genes:a:akirin2|AKIRIN2]]|0.42|
|[[:human genes:p:psma1|PSMA1]]|0.419|
|[[:human genes:r:rps20|RPS20]]|0.418|
|[[:human genes:r:rfxank|RFXANK]]|0.418|
|[[:human genes:u:uba52|UBA52]]|0.418|
|[[:human genes:c:cox8a|COX8A]]|0.418|
|[[:human genes:r:rrp7a|RRP7A]]|0.418|
|[[:human genes:m:myh2|MYH2]]|0.417|
|[[:human genes:c:ctage4|CTAGE4]]|0.416|
|[[:human genes:r:rnpc3|RNPC3]]|0.416|
|[[:human genes:n:nip7|NIP7]]|0.416|
|[[:human genes:p:psap|PSAP]]|0.416|
|[[:human genes:s:sf3a2|SF3A2]]|0.415|
|[[:human genes:r:riok2|RIOK2]]|0.415|
|[[:human genes:m:mms22l|MMS22L]]|0.414|
|[[:human genes:k:krt78|KRT78]]|0.413|
|[[:human genes:m:med12|MED12]]|0.413|
|[[:human genes:l:lad1|LAD1]]|0.413|
|[[:human genes:n:nfatc4|NFATC4]]|0.413|
|[[:human genes:b:brd2|BRD2]]|0.413|
|[[:human genes:c:cln6|CLN6]]|0.412|
|[[:human genes:r:rpl34|RPL34]]|0.412|
|[[:human genes:h:hnrnpa1|HNRNPA1]]|0.412|
|[[:human genes:p:psmb3|PSMB3]]|0.412|
|[[:human genes:s:slc6a17|SLC6A17]]|0.411|
|[[:human genes:a:aaas|AAAS]]|0.411|
|[[:human genes:z:znf655|ZNF655]]|0.411|
|[[:human genes:h:hivep3|HIVEP3]]|0.411|
|[[:human genes:r:rps28|RPS28]]|0.41|
|[[:human genes:d:dnm2|DNM2]]|0.41|
|[[:human genes:m:myo18a|MYO18A]]|0.41|
|[[:human genes:p:phf2|PHF2]]|0.41|
|[[:human genes:m:myh7b|MYH7B]]|0.409|
|[[:human genes:g:golga6a|GOLGA6A]]|0.409|
|[[:human genes:r:rps5|RPS5]]|0.409|
|[[:human genes:n:nup153|NUP153]]|0.408|
|[[:human genes:f:fancm|FANCM]]|0.408|
|[[:human genes:o:or10g3|OR10G3]]|0.407|
|[[:human genes:h:hmgcr|HMGCR]]|0.407|
|[[:human genes:s:sh3bp1|SH3BP1]]|0.407|
|[[:human genes:z:znf574|ZNF574]]|0.406|
|[[:human genes:p:ppfia4|PPFIA4]]|0.406|
|[[:human genes:p:psmd13|PSMD13]]|0.406|
|[[:human genes:c:cacna1a|CACNA1A]]|0.404|
|[[:human genes:f:fam20a|FAM20A]]|0.404|
|[[:human genes:s:snrnp70|SNRNP70]]|0.404|
|[[:human genes:n:napa|NAPA]]|0.403|
|[[:human genes:n:nelfcd|NELFCD]]|0.402|
|[[:human genes:u:usp35|USP35]]|0.402|
|[[:human genes:m:myt1l|MYT1L]]|0.401|
|[[:human genes:n:npipb8|NPIPB8]]|0.401|
|[[:human genes:s:sel1l|SEL1L]]|0.401|
|[[:human genes:c:clasp1|CLASP1]]|0.401|
|[[:human genes:s:sfpq|SFPQ]]|0.401|
|[[:human genes:c:cwc15|CWC15]]|0.4|
|[[:human genes:p:polr2l|POLR2L]]|0.4|
|[[:human genes:d:ddx51|DDX51]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1504
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.74 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MT1E Expression in NALM6 Cells: 0.74'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>