MTA2 [The Human Chemical-Genetic Interaction Map Project]

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======= MTA2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MTA2
  * **<color #00a2e8>Official Name</color>**: metastasis associated 1 family member 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9219|9219]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O94776|O94776]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MTA2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MTA2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603947|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  May be involved in the regulation of gene expression as repressor and activator. The repression might be related to covalent modification of histone proteins.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|GATA|
|ELM2|
|BAH|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|NuRD complex|
|histone deacetylase activity|
|regulation of fibroblast migration|
|RNA polymerase II repressing transcription factor binding|
|histone deacetylase complex|
|nucleosomal DNA binding|
|DNA alkylation|
|DNA methylation|
|histone deacetylation|
|protein deacetylation|
|protein deacylation|
|macromolecule deacylation|
|RNA polymerase II transcription factor binding|
|DNA methylation or demethylation|
|transcription regulatory region sequence-specific DNA binding|
|ATP-dependent chromatin remodeling|
|DNA modification|
|histone deacetylase binding|
|chromatin assembly or disassembly|
|chromatin remodeling|
|regulation of signal transduction by p53 class mediator|
|transcription factor complex|
|nuclear chromatin|
|transcription corepressor activity|
|macromolecule methylation|
|transcription coactivator activity|
|methylation|
|histone modification|
|covalent chromatin modification|
|protein-containing complex|
|chromatin organization|
|DNA metabolic process|
|zinc ion binding|
|regulation of cell migration|
|negative regulation of transcription by RNA polymerase II|
|regulation of cell motility|
|regulation of locomotion|
|regulation of cellular component movement|
|chromosome organization|
|negative regulation of transcription, DNA-templated|
|positive regulation of transcription by RNA polymerase II|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of RNA metabolic process|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|positive regulation of transcription, DNA-templated|
|negative regulation of biosynthetic process|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|regulation of intracellular signal transduction|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|membrane|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|-2.62|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|-2.51|
|[[:results:exp208|Vinblastine 0.015μM R05 exp208]]|-2.28|
|[[:results:exp463|Caffeine 2600μM R08 exp463]]|-2.18|
|[[:results:exp417|Tubastatin-A 2.5μM R07 exp417]]|-1.99|
|[[:results:exp38|Wortmannin 5μM R00 exp38]]|-1.97|
|[[:results:exp199|Etoposide 0.3μM R05 exp199]]|-1.92|
|[[:results:exp60|Vinblastine 0.002μM R01 exp60]]|1.7|
|[[:results:exp228|Demecolcine 0.03μM R05 exp228]]|1.73|
|[[:results:exp46|HMS-I1 1μM R01 exp46]]|1.78|
|[[:results:exp433|LJH685 50μM R08 exp433]]|1.78|
|[[:results:exp238|Parthenolide 2.5μM R05 exp238]]|1.79|
|[[:results:exp333|All-trans-Retinoic-Acid 8μM R07 exp333]]|1.81|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|1.9|
|[[:results:exp461|BS-181 20μM R08 exp461]]|1.92|
|[[:results:exp326|CCT251545 20μM R07 exp326]]|1.96|
|[[:results:exp183|IU1-C 25μM R04 exp183]]|1.96|
|[[:results:exp438|NN-Diethyl-meta-toluamide 500μM R08 exp438]]|1.98|
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|2.02|
|[[:results:exp538|ZLN024 50μM R08 exp538]]|2.02|
|[[:results:exp212|Phenformin 20μM R05 exp212]]|2.03|
|[[:results:exp454|Bafilomycin-A1 0.009μM R08 exp454]]|2.04|
|[[:results:exp241|QNZ 0.01μM R05 exp241]]|2.06|
|[[:results:exp209|Deguelin 0.15μM R05 exp209]]|2.13|
|[[:results:exp59|UMK57 1μM R01 exp59]]|2.25|
|[[:results:exp510|Nicotine 3000μM R08 exp510]]|2.45|
|[[:results:exp175|3-Bromopyruvate 7μM R04 exp175]]|2.48|
|[[:results:exp274|Citral 50μM R06 exp274]]|2.49|
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|2.53|
|[[:results:exp248|UM0131023 0.05μM R05 exp248]]|3.45|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:m:mbd3|MBD3]]|0.56|
|[[:human genes:h:hdac1|HDAC1]]|0.535|
|[[:human genes:h:hgc6.3|HGC6.3]]|0.525|
|[[:human genes:g:gatad2a|GATAD2A]]|0.476|
|[[:human genes:h:hdac2|HDAC2]]|0.441|
|[[:human genes:r:rcor1|RCOR1]]|0.406|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 5/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|1/28|
|bone|0/25|
|breast|1/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|1/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|2/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2202
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.92 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MTA2 Expression in NALM6 Cells: 7.92'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>