MTF2 [The Human Chemical-Genetic Interaction Map Project]

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======= MTF2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MTF2
  * **<color #00a2e8>Official Name</color>**: metal response element binding transcription factor 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=22823|22823]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y483|Q9Y483]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MTF2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MTF2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/609882|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Polycomb group (PcG) that specifically binds histone H3 trimethylated at 'Lys-36' (H3K36me3) and recruits the PRC2 complex. Acts by binding to H3K36me3, a mark for transcriptional activation, and recruiting the PRC2 complex, leading to enhance PRC2 H3K27me3 methylation activity. Regulates the transcriptional networks during embryonic stem cell self-renewal and differentiation. Promotes recruitment of the PRC2 complex to the inactive X chromosome in differentiating XX ES cells and PRC2 recruitment to target genes in undifferentiated ES cells. Required to repress Hox genes by enhancing H3K27me3 methylation of the PRC2 complex. In some conditions may act as an inhibitor of PRC2 activity: able to activate the CDKN2A gene and promote cellular senescence by suppressing the catalytic activity of the PRC2 complex locally. Binds to the metal-regulating-element (MRE) of MT1A gene promoter (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PHD|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of histone H3-K27 methylation|
|positive regulation of histone H3-K27 methylation|
|regulation of histone H3-K27 methylation|
|ESC/E(Z) complex|
|segment specification|
|negative regulation of histone methylation|
|nucleosome binding|
|positive regulation of histone methylation|
|negative regulation of histone modification|
|negative regulation of chromatin organization|
|methylated histone binding|
|regulation of histone methylation|
|negative regulation of gene expression, epigenetic|
|positive regulation of histone modification|
|segmentation|
|cellular response to leukemia inhibitory factor|
|response to leukemia inhibitory factor|
|positive regulation of chromatin organization|
|negative regulation of chromosome organization|
|stem cell population maintenance|
|maintenance of cell number|
|regulation of histone modification|
|stem cell differentiation|
|positive regulation of chromosome organization|
|regulation of chromatin organization|
|regulation of gene expression, epigenetic|
|RNA polymerase II regulatory region sequence-specific DNA binding|
|regionalization|
|regulation of chromosome organization|
|negative regulation of organelle organization|
|focal adhesion|
|sequence-specific DNA binding|
|pattern specification process|
|negative regulation of protein modification process|
|positive regulation of organelle organization|
|DNA-binding transcription factor activity|
|chromatin organization|
|negative regulation of cellular component organization|
|negative regulation of transcription by RNA polymerase II|
|cellular response to cytokine stimulus|
|negative regulation of cellular protein metabolic process|
|chromosome organization|
|response to cytokine|
|negative regulation of protein metabolic process|
|negative regulation of transcription, DNA-templated|
|positive regulation of cellular component organization|
|positive regulation of transcription by RNA polymerase II|
|positive regulation of protein modification process|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|regulation of organelle organization|
|negative regulation of RNA metabolic process|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|positive regulation of transcription, DNA-templated|
|negative regulation of biosynthetic process|
|positive regulation of cellular protein metabolic process|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|positive regulation of protein metabolic process|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|regulation of protein modification process|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|-3.98|
|[[:results:exp447|Amiloride 100μM R08 exp447]]|-3.05|
|[[:results:exp134|MS023 2μM R03 exp134]]|-2.91|
|[[:results:exp455|Benzoate 10000μM R08 exp455]]|-2.81|
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|-2.58|
|[[:results:exp226|Cerivastatin 0.15μM R05 exp226]]|-2.52|
|[[:results:exp233|EPZ-5676 30μM R05 exp233]]|-2.47|
|[[:results:exp407|Thapsigargin 0.005μM R07 exp407]]|-2.46|
|[[:results:exp190|Vincristine 0.0005μM R04 exp190]]|-2.41|
|[[:results:exp234|Ethanol 0.01 R05 exp234]]|-2.31|
|[[:results:exp102|Nifuroxazide 5μM R03 exp102]]|-2.3|
|[[:results:exp330|5-Azacytidine 2μM R07 exp330]]|-2.25|
|[[:results:exp534|Trientine 500μM R08 exp534]]|-2.1|
|[[:results:exp354|Diepoxybutane 3μM R07 exp354]]|-2.09|
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|-2.09|
|[[:results:exp198|Etoposide 0.1μM R05 exp198]]|-2.01|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|-1.98|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|-1.95|
|[[:results:exp47|Lapatinib 5μM R01 exp47]]|-1.92|
|[[:results:exp514|Phorbol-12-myristate-13-acetate 0.57μM R08 exp514]]|-1.92|
|[[:results:exp298|Sucrose 20000μM R06 exp298]]|-1.83|
|[[:results:exp453|B02 10μM R08 exp453]]|-1.82|
|[[:results:exp240|Pyridostatin 4μM R05 exp240]]|-1.82|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|-1.79|
|[[:results:exp125|GSK461364A 0.005μM R03 exp125]]|-1.77|
|[[:results:exp274|Citral 50μM R06 exp274]]|-1.72|
|[[:results:exp61|YM155 0.0002μM R01 exp61]]|-1.72|
|[[:results:exp470|Chloroquine 32μM R08 exp470]]|1.83|
|[[:results:exp37|Wortmannin 0.5μM R00 exp37]]|1.92|
|[[:results:exp89|Vemurafenib 6.6μM R02 exp89]]|1.95|
|[[:results:exp346|CoCl2 18μM R07 exp346]]|2.13|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|1/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 14154
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.83 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MTF2 Expression in NALM6 Cells: 6.83'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>