MTMR6 [The Human Chemical-Genetic Interaction Map Project]

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======= MTMR6 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MTMR6
  * **<color #00a2e8>Official Name</color>**: myotubularin related protein 6
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9107|9107]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y217|Q9Y217]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MTMR6&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MTMR6|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603561|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Phosphatase that acts on lipids with a phosphoinositol headgroup. Acts as a negative regulator of KCNN4/KCa3.1 channel activity in CD4+ T-cells possibly by decreasing intracellular levels of phosphatidylinositol 3 phosphatase. Negatively regulates proliferation of reactivated CD4+ T-cells. {ECO:0000269|PubMed:15831468, ECO:0000269|PubMed:16847315}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Myotub-related|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|phosphatidylinositol-3,5-bisphosphate phosphatase activity|
|phosphatidylinositol-3-phosphatase activity|
|calcium-activated potassium channel activity|
|phosphatidylinositol dephosphorylation|
|phospholipid dephosphorylation|
|protein serine/threonine phosphatase activity|
|endoplasmic reticulum-Golgi intermediate compartment|
|ruffle membrane|
|protein tyrosine phosphatase activity|
|peptidyl-tyrosine dephosphorylation|
|phosphatidylinositol biosynthetic process|
|potassium ion transmembrane transport|
|potassium ion transport|
|phosphatidylinositol metabolic process|
|nuclear envelope|
|lipid modification|
|glycerophospholipid biosynthetic process|
|protein dephosphorylation|
|glycerolipid biosynthetic process|
|phospholipid biosynthetic process|
|glycerophospholipid metabolic process|
|dephosphorylation|
|phospholipid metabolic process|
|glycerolipid metabolic process|
|monovalent inorganic cation transport|
|organophosphate biosynthetic process|
|endocytosis|
|inorganic cation transmembrane transport|
|lipid biosynthetic process|
|cation transmembrane transport|
|metal ion transport|
|inorganic ion transmembrane transport|
|import into cell|
|perinuclear region of cytoplasm|
|cation transport|
|organophosphate metabolic process|
|ion transmembrane transport|
|cellular lipid metabolic process|
|endoplasmic reticulum|
|lipid metabolic process|
|transmembrane transport|
|ion transport|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp89|Vemurafenib 6.6μM R02 exp89]]|-3.53|
|[[:results:exp226|Cerivastatin 0.15μM R05 exp226]]|-2.54|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|-2.51|
|[[:results:exp530|Thioridazine 5μM R08 exp530]]|-2.25|
|[[:results:exp454|Bafilomycin-A1 0.009μM R08 exp454]]|-2.03|
|[[:results:exp169|BH1 1μM R04 exp169]]|-2|
|[[:results:exp282|Fluvastatin 2.2μM R06 exp282]]|-1.96|
|[[:results:exp422|Wiskostatin 3μM R07 exp422]]|-1.93|
|[[:results:exp300|VE-822 0.04μM R06 exp300]]|-1.9|
|[[:results:exp68|Clomiphene 4.4μM R02 exp68]]|-1.88|
|[[:results:exp190|Vincristine 0.0005μM R04 exp190]]|1.75|
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|1.87|
|[[:results:exp501|Methotrexate 0.01μM R08 exp501]]|2|
|[[:results:exp122|Golgicide-A 4μM R03 exp122]]|2.79|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hgc6.3|HGC6.3]]|0.564|
|[[:human genes:m:mtmr9|MTMR9]]|0.53|
|[[:human genes:r:rab1b|RAB1B]]|0.497|
|[[:human genes:u:unc50|UNC50]]|0.474|
|[[:human genes:t:tbc1d23|TBC1D23]]|0.449|
|[[:human genes:v:vps41|VPS41]]|0.426|
|[[:human genes:c:cog6|COG6]]|0.415|
|[[:human genes:c:cog7|COG7]]|0.414|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 9354
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.08 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MTMR6 Expression in NALM6 Cells: 5.08'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>