MTO1 [The Human Chemical-Genetic Interaction Map Project]

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======= MTO1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MTO1
  * **<color #00a2e8>Official Name</color>**: mitochondrial tRNA translation optimization 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=25821|25821]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y2Z2|Q9Y2Z2]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MTO1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MTO1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/614667|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a mitochondrial protein thought to be involved in mitochondrial tRNA modification. The encoded protein may also play a role in the expression of the non-syndromic and aminoglycoside-induced deafness phenotypes associated with a specific mutation in the mitochondrial 12S rRNA gene. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|GIDA|
|Pyr redox 2|
|FAD oxidored|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|mitochondrial tRNA wobble uridine modification|
|mitochondrial tRNA modification|
|mitochondrial RNA modification|
|mitochondrial tRNA processing|
|tRNA threonylcarbamoyladenosine metabolic process|
|mitochondrial RNA processing|
|tRNA wobble uridine modification|
|tRNA wobble base modification|
|tRNA methylation|
|mitochondrial RNA metabolic process|
|flavin adenine dinucleotide binding|
|RNA methylation|
|tRNA modification|
|tRNA processing|
|mitochondrial gene expression|
|RNA modification|
|tRNA metabolic process|
|macromolecule methylation|
|methylation|
|ncRNA processing|
|ncRNA metabolic process|
|RNA processing|
|mitochondrion|
|RNA binding|
|RNA metabolic process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp452|Azithromycin 100μM R08 exp452]]|1.7|
|[[:results:exp65|Mubritinib 0.2μM R02 exp65]]|1.72|
|[[:results:exp287|HMS-I2 5μM R06 exp287]]|1.78|
|[[:results:exp342|Calcium Ionophore 0.4μM R07 exp342]]|1.8|
|[[:results:exp189|Temozolomide 200μM R04 exp189]]|1.81|
|[[:results:exp527|Tanespimycin 14μM R08 exp527]]|1.82|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|1.88|
|[[:results:exp470|Chloroquine 32μM R08 exp470]]|2.12|
|[[:results:exp52|Ribavirin 10μM R01 exp52]]|2.19|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|2.36|
|[[:results:exp360|Genistein 15μM R07 exp360]]|2.37|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|2.94|
|[[:results:exp288|HMS-I2 10μM R06 exp288]]|3.24|
|[[:results:exp160|Ribavirin 10 to 15μM on day4 R04 exp160]]|3.43|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:g:grsf1|GRSF1]]|0.702|
|[[:human genes:a:acad9|ACAD9]]|0.675|
|[[:human genes:n:ndufaf3|NDUFAF3]]|0.656|
|[[:human genes:n:nubpl|NUBPL]]|0.651|
|[[:human genes:n:ndufs2|NDUFS2]]|0.65|
|[[:human genes:n:ndufb11|NDUFB11]]|0.645|
|[[:human genes:n:ndufa2|NDUFA2]]|0.643|
|[[:human genes:n:ndufaf7|NDUFAF7]]|0.635|
|[[:human genes:n:ndufa1|NDUFA1]]|0.632|
|[[:human genes:n:ndufb9|NDUFB9]]|0.632|
|[[:human genes:n:ndufaf6|NDUFAF6]]|0.625|
|[[:human genes:t:timmdc1|TIMMDC1]]|0.619|
|[[:human genes:n:ndufs8|NDUFS8]]|0.614|
|[[:human genes:n:ndufa11|NDUFA11]]|0.601|
|[[:human genes:n:ndufb7|NDUFB7]]|0.598|
|[[:human genes:f:fastkd2|FASTKD2]]|0.595|
|[[:human genes:c:chchd1|CHCHD1]]|0.594|
|[[:human genes:n:ndufs5|NDUFS5]]|0.592|
|[[:human genes:e:ecsit|ECSIT]]|0.586|
|[[:human genes:n:ndufc2|NDUFC2]]|0.576|
|[[:human genes:n:ndufa8|NDUFA8]]|0.571|
|[[:human genes:n:ndufb10|NDUFB10]]|0.571|
|[[:human genes:m:mcat|MCAT]]|0.57|
|[[:human genes:n:ndufa3|NDUFA3]]|0.568|
|[[:human genes:n:ndufa10|NDUFA10]]|0.567|
|[[:human genes:m:mtrf1l|MTRF1L]]|0.561|
|[[:human genes:p:pet117|PET117]]|0.559|
|[[:human genes:n:ndufb6|NDUFB6]]|0.558|
|[[:human genes:g:gtpbp10|GTPBP10]]|0.555|
|[[:human genes:n:ndufc1|NDUFC1]]|0.549|
|[[:human genes:i:iba57|IBA57]]|0.548|
|[[:human genes:p:pde12|PDE12]]|0.546|
|[[:human genes:n:ndufs7|NDUFS7]]|0.545|
|[[:human genes:n:ndufaf5|NDUFAF5]]|0.543|
|[[:human genes:m:malsu1|MALSU1]]|0.537|
|[[:human genes:c:c12orf65|C12orf65]]|0.535|
|[[:human genes:n:ndufaf1|NDUFAF1]]|0.533|
|[[:human genes:r:rpusd3|RPUSD3]]|0.531|
|[[:human genes:f:foxred1|FOXRED1]]|0.53|
|[[:human genes:p:polg2|POLG2]]|0.523|
|[[:human genes:f:ftsj2|FTSJ2]]|0.522|
|[[:human genes:p:pet112|PET112]]|0.522|
|[[:human genes:m:mettl17|METTL17]]|0.522|
|[[:human genes:m:mrps27|MRPS27]]|0.514|
|[[:human genes:s:sfxn4|SFXN4]]|0.513|
|[[:human genes:n:ndufv2|NDUFV2]]|0.511|
|[[:human genes:c:coq7|COQ7]]|0.509|
|[[:human genes:m:mtif2|MTIF2]]|0.508|
|[[:human genes:n:ndufb5|NDUFB5]]|0.506|
|[[:human genes:g:gfm2|GFM2]]|0.505|
|[[:human genes:q:qrsl1|QRSL1]]|0.504|
|[[:human genes:n:ndufa6|NDUFA6]]|0.503|
|[[:human genes:a:atp5sl|ATP5SL]]|0.502|
|[[:human genes:m:mterfd1|MTERFD1]]|0.5|
|[[:human genes:p:polg|POLG]]|0.499|
|[[:human genes:n:ndufb2|NDUFB2]]|0.498|
|[[:human genes:n:ndufv1|NDUFV1]]|0.492|
|[[:human genes:n:ndufa13|NDUFA13]]|0.49|
|[[:human genes:n:ndufa9|NDUFA9]]|0.49|
|[[:human genes:n:nars2|NARS2]]|0.49|
|[[:human genes:y:ybey|YBEY]]|0.487|
|[[:human genes:m:mtg1|MTG1]]|0.486|
|[[:human genes:m:mrps21|MRPS21]]|0.485|
|[[:human genes:c:coq2|COQ2]]|0.484|
|[[:human genes:m:mrps18b|MRPS18B]]|0.484|
|[[:human genes:r:rtn4ip1|RTN4IP1]]|0.483|
|[[:human genes:n:ndufa5|NDUFA5]]|0.483|
|[[:human genes:c:c1qbp|C1QBP]]|0.481|
|[[:human genes:t:tmem261|TMEM261]]|0.479|
|[[:human genes:e:eral1|ERAL1]]|0.479|
|[[:human genes:n:nsun4|NSUN4]]|0.478|
|[[:human genes:g:gfm1|GFM1]]|0.478|
|[[:human genes:s:ssbp1|SSBP1]]|0.477|
|[[:human genes:l:lars2|LARS2]]|0.476|
|[[:human genes:r:rmnd1|RMND1]]|0.475|
|[[:human genes:m:mrpl1|MRPL1]]|0.474|
|[[:human genes:g:gtpbp8|GTPBP8]]|0.472|
|[[:human genes:n:ndufb4|NDUFB4]]|0.47|
|[[:human genes:d:ddx28|DDX28]]|0.469|
|[[:human genes:n:ndufaf4|NDUFAF4]]|0.467|
|[[:human genes:c:c17orf89|C17orf89]]|0.464|
|[[:human genes:c:cars2|CARS2]]|0.462|
|[[:human genes:g:glrx5|GLRX5]]|0.461|
|[[:human genes:m:mipep|MIPEP]]|0.458|
|[[:human genes:c:clpp|CLPP]]|0.457|
|[[:human genes:n:ndufs1|NDUFS1]]|0.456|
|[[:human genes:p:prepl|PREPL]]|0.455|
|[[:human genes:h:hmgxb3|HMGXB3]]|0.455|
|[[:human genes:r:rbfa|RBFA]]|0.454|
|[[:human genes:n:ndufs3|NDUFS3]]|0.453|
|[[:human genes:m:mrpl13|MRPL13]]|0.451|
|[[:human genes:t:tfb1m|TFB1M]]|0.451|
|[[:human genes:p:polrmt|POLRMT]]|0.451|
|[[:human genes:m:mrpl45|MRPL45]]|0.448|
|[[:human genes:n:nfu1|NFU1]]|0.446|
|[[:human genes:r:rnaseh1|RNASEH1]]|0.444|
|[[:human genes:c:coa6|COA6]]|0.443|
|[[:human genes:n:noa1|NOA1]]|0.442|
|[[:human genes:m:mdh2|MDH2]]|0.437|
|[[:human genes:a:aars2|AARS2]]|0.436|
|[[:human genes:n:ndufb3|NDUFB3]]|0.436|
|[[:human genes:c:coa3|COA3]]|0.431|
|[[:human genes:m:mrpl47|MRPL47]]|0.431|
|[[:human genes:m:mtg2|MTG2]]|0.43|
|[[:human genes:i:ict1|ICT1]]|0.429|
|[[:human genes:c:cox11|COX11]]|0.429|
|[[:human genes:y:yars2|YARS2]]|0.427|
|[[:human genes:r:rpusd4|RPUSD4]]|0.425|
|[[:human genes:m:mrpl21|MRPL21]]|0.424|
|[[:human genes:m:mrpl43|MRPL43]]|0.423|
|[[:human genes:m:mpv17l2|MPV17L2]]|0.423|
|[[:human genes:h:hsd17b10|HSD17B10]]|0.421|
|[[:human genes:w:wbscr16|WBSCR16]]|0.421|
|[[:human genes:s:slc25a3|SLC25A3]]|0.421|
|[[:human genes:t:tars2|TARS2]]|0.42|
|[[:human genes:n:nsun3|NSUN3]]|0.42|
|[[:human genes:s:selrc1|SELRC1]]|0.418|
|[[:human genes:f:fastkd5|FASTKD5]]|0.418|
|[[:human genes:a:ak3|AK3]]|0.415|
|[[:human genes:m:mrps25|MRPS25]]|0.413|
|[[:human genes:g:gtpbp6|GTPBP6]]|0.412|
|[[:human genes:f:fastkd1|FASTKD1]]|0.408|
|[[:human genes:m:mrpl3|MRPL3]]|0.408|
|[[:human genes:m:mrps34|MRPS34]]|0.407|
|[[:human genes:m:mrpl4|MRPL4]]|0.407|
|[[:human genes:g:got2|GOT2]]|0.405|
|[[:human genes:e:ears2|EARS2]]|0.405|
|[[:human genes:m:mrpl15|MRPL15]]|0.404|
|[[:human genes:n:ndufb8|NDUFB8]]|0.401|
|[[:human genes:m:mrpl22|MRPL22]]|0.4|
|[[:human genes:m:mrps26|MRPS26]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|1/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1114
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.37 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MTO1 Expression in NALM6 Cells: 6.37'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>