MTPAP [The Human Chemical-Genetic Interaction Map Project]

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======= MTPAP =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MTPAP
  * **<color #00a2e8>Official Name</color>**: mitochondrial poly(A) polymerase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=55149|55149]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9NVV4|Q9NVV4]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MTPAP&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MTPAP|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/613669|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a member of the DNA polymerase type-B-like family. This enzyme synthesizes the 3' poly(A) tail of mitochondrial transcripts and plays a role in replication-dependent histone mRNA degradation.[provided by RefSeq, Jan 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Polymerase that creates the 3' poly(A) tail of mitochondrial transcripts. Can use all four nucleotides, but has higher activity with ATP and UTP (in vitro). Plays a role in replication-dependent histone mRNA degradation. May be involved in the terminal uridylation of mature histone mRNAs before their degradation is initiated. Might be responsible for the creation of some UAA stop codons which are not encoded in mtDNA. {ECO:0000269|PubMed:15547249, ECO:0000269|PubMed:15769737, ECO:0000269|PubMed:18172165, ECO:0000269|PubMed:20970105, ECO:0000269|PubMed:21292163}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PAP assoc|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|UTP binding|
|polynucleotide adenylyltransferase activity|
|histone mRNA catabolic process|
|mRNA polyadenylation|
|histone mRNA metabolic process|
|RNA polyadenylation|
|manganese ion binding|
|mRNA 3-end processing|
|RNA 3-end processing|
|nuclear-transcribed mRNA catabolic process|
|magnesium ion binding|
|mRNA catabolic process|
|RNA catabolic process|
|nucleobase-containing compound catabolic process|
|heterocycle catabolic process|
|cellular nitrogen compound catabolic process|
|aromatic compound catabolic process|
|mRNA processing|
|organic cyclic compound catabolic process|
|intracellular membrane-bounded organelle|
|mRNA metabolic process|
|RNA processing|
|protein homodimerization activity|
|cellular macromolecule catabolic process|
|macromolecule catabolic process|
|identical protein binding|
|mitochondrion|
|RNA binding|
|ATP binding|
|RNA metabolic process|
|negative regulation of gene expression|
|organic substance catabolic process|
|cellular catabolic process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp143|Phenformin 20μM R03 exp143]]|1.73|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|1.74|
|[[:results:exp290|LLY-283 2.6μM R06 exp290]]|1.84|
|[[:results:exp211|AICAR 240μM R05 exp211]]|1.99|
|[[:results:exp474|CR131-b 0.005μM R08 exp474]]|2.03|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|2.1|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|2.3|
|[[:results:exp350|Deferoxamine 11μM R07 exp350]]|2.45|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|2.64|
|[[:results:exp441|GSK-J4 1.5μM R08 exp441]]|2.86|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:m:mrpl23|MRPL23]]|0.623|
|[[:human genes:y:yars2|YARS2]]|0.621|
|[[:human genes:m:mrpl21|MRPL21]]|0.614|
|[[:human genes:h:hsd17b10|HSD17B10]]|0.608|
|[[:human genes:r:rpusd4|RPUSD4]]|0.603|
|[[:human genes:m:mrps5|MRPS5]]|0.594|
|[[:human genes:m:mrpl55|MRPL55]]|0.591|
|[[:human genes:k:kiaa0391|KIAA0391]]|0.588|
|[[:human genes:m:mrps34|MRPS34]]|0.587|
|[[:human genes:c:cox16|COX16]]|0.581|
|[[:human genes:b:bcs1l|BCS1L]]|0.575|
|[[:human genes:m:mrps12|MRPS12]]|0.57|
|[[:human genes:f:fastkd5|FASTKD5]]|0.569|
|[[:human genes:t:trub2|TRUB2]]|0.568|
|[[:human genes:s:selrc1|SELRC1]]|0.564|
|[[:human genes:m:mtg2|MTG2]]|0.562|
|[[:human genes:m:mrps18a|MRPS18A]]|0.56|
|[[:human genes:g:gfm2|GFM2]]|0.556|
|[[:human genes:t:tars2|TARS2]]|0.551|
|[[:human genes:m:mrps6|MRPS6]]|0.548|
|[[:human genes:s:supv3l1|SUPV3L1]]|0.548|
|[[:human genes:m:mrps16|MRPS16]]|0.548|
|[[:human genes:c:cox17|COX17]]|0.544|
|[[:human genes:m:mrp63|MRP63]]|0.544|
|[[:human genes:m:mrps26|MRPS26]]|0.543|
|[[:human genes:s:sco2|SCO2]]|0.542|
|[[:human genes:m:mrps2|MRPS2]]|0.538|
|[[:human genes:m:mrpl53|MRPL53]]|0.537|
|[[:human genes:c:cox7b|COX7B]]|0.536|
|[[:human genes:m:mrps21|MRPS21]]|0.535|
|[[:human genes:q:qrsl1|QRSL1]]|0.534|
|[[:human genes:m:mrpl47|MRPL47]]|0.532|
|[[:human genes:s:sars2|SARS2]]|0.531|
|[[:human genes:d:dap3|DAP3]]|0.531|
|[[:human genes:v:vars2|VARS2]]|0.526|
|[[:human genes:c:coa6|COA6]]|0.523|
|[[:human genes:m:mrps9|MRPS9]]|0.521|
|[[:human genes:c:coa5|COA5]]|0.519|
|[[:human genes:m:mrpl44|MRPL44]]|0.518|
|[[:human genes:m:mrpl12|MRPL12]]|0.515|
|[[:human genes:g:gfm1|GFM1]]|0.511|
|[[:human genes:w:wbscr16|WBSCR16]]|0.511|
|[[:human genes:p:pnpt1|PNPT1]]|0.507|
|[[:human genes:t:timm8b|TIMM8B]]|0.507|
|[[:human genes:m:mrps25|MRPS25]]|0.507|
|[[:human genes:c:c17orf89|C17orf89]]|0.504|
|[[:human genes:d:dars2|DARS2]]|0.503|
|[[:human genes:g:gtpbp10|GTPBP10]]|0.5|
|[[:human genes:m:mrps14|MRPS14]]|0.5|
|[[:human genes:c:coa3|COA3]]|0.499|
|[[:human genes:f:ftsj2|FTSJ2]]|0.495|
|[[:human genes:c:cox6b1|COX6B1]]|0.495|
|[[:human genes:p:pdss1|PDSS1]]|0.494|
|[[:human genes:m:mrps10|MRPS10]]|0.494|
|[[:human genes:c:cox6c|COX6C]]|0.493|
|[[:human genes:c:cox15|COX15]]|0.493|
|[[:human genes:m:mrpl15|MRPL15]]|0.492|
|[[:human genes:c:c12orf65|C12orf65]]|0.492|
|[[:human genes:m:mrps24|MRPS24]]|0.492|
|[[:human genes:e:ears2|EARS2]]|0.488|
|[[:human genes:m:mars2|MARS2]]|0.487|
|[[:human genes:u:uqcr10|UQCR10]]|0.485|
|[[:human genes:m:mrpl3|MRPL3]]|0.483|
|[[:human genes:m:mrpl36|MRPL36]]|0.483|
|[[:human genes:u:uqcrq|UQCRQ]]|0.483|
|[[:human genes:a:aars2|AARS2]]|0.482|
|[[:human genes:d:dhx30|DHX30]]|0.481|
|[[:human genes:m:mrpl2|MRPL2]]|0.481|
|[[:human genes:n:nars2|NARS2]]|0.48|
|[[:human genes:t:tufm|TUFM]]|0.478|
|[[:human genes:s:slc25a26|SLC25A26]]|0.477|
|[[:human genes:p:pars2|PARS2]]|0.476|
|[[:human genes:r:rnaseh1|RNASEH1]]|0.476|
|[[:human genes:m:mrpl45|MRPL45]]|0.475|
|[[:human genes:m:mrpl37|MRPL37]]|0.474|
|[[:human genes:m:mrps22|MRPS22]]|0.472|
|[[:human genes:m:mrpl20|MRPL20]]|0.471|
|[[:human genes:r:rars2|RARS2]]|0.47|
|[[:human genes:p:ptcd3|PTCD3]]|0.465|
|[[:human genes:c:cox11|COX11]]|0.462|
|[[:human genes:m:mrpl11|MRPL11]]|0.462|
|[[:human genes:r:rbfa|RBFA]]|0.46|
|[[:human genes:m:mrpl34|MRPL34]]|0.458|
|[[:human genes:c:chchd1|CHCHD1]]|0.457|
|[[:human genes:m:mrpl42|MRPL42]]|0.456|
|[[:human genes:f:fars2|FARS2]]|0.456|
|[[:human genes:c:coq3|COQ3]]|0.454|
|[[:human genes:c:chchd4|CHCHD4]]|0.454|
|[[:human genes:m:mtg1|MTG1]]|0.453|
|[[:human genes:u:uqcc2|UQCC2]]|0.451|
|[[:human genes:c:c10orf2|C10orf2]]|0.448|
|[[:human genes:m:mrpl18|MRPL18]]|0.448|
|[[:human genes:n:ndufb11|NDUFB11]]|0.447|
|[[:human genes:n:ndufc2|NDUFC2]]|0.446|
|[[:human genes:m:mrpl33|MRPL33]]|0.445|
|[[:human genes:m:mtrf1l|MTRF1L]]|0.445|
|[[:human genes:n:ndufa3|NDUFA3]]|0.445|
|[[:human genes:t:tefm|TEFM]]|0.443|
|[[:human genes:c:coq2|COQ2]]|0.442|
|[[:human genes:m:mterfd2|MTERFD2]]|0.44|
|[[:human genes:l:lars2|LARS2]]|0.44|
|[[:human genes:m:mrps35|MRPS35]]|0.439|
|[[:human genes:h:hars2|HARS2]]|0.436|
|[[:human genes:p:pet117|PET117]]|0.434|
|[[:human genes:s:slc31a1|SLC31A1]]|0.434|
|[[:human genes:t:tomm40|TOMM40]]|0.433|
|[[:human genes:a:aasdhppt|AASDHPPT]]|0.432|
|[[:human genes:m:mrpl48|MRPL48]]|0.429|
|[[:human genes:c:cycs|CYCS]]|0.428|
|[[:human genes:m:mrpl49|MRPL49]]|0.425|
|[[:human genes:t:tmem126b|TMEM126B]]|0.425|
|[[:human genes:u:uqcrc2|UQCRC2]]|0.424|
|[[:human genes:t:tomm20|TOMM20]]|0.421|
|[[:human genes:n:ndufaf7|NDUFAF7]]|0.421|
|[[:human genes:m:mrps23|MRPS23]]|0.419|
|[[:human genes:l:lrpprc|LRPPRC]]|0.419|
|[[:human genes:m:mettl17|METTL17]]|0.418|
|[[:human genes:g:gatc|GATC]]|0.417|
|[[:human genes:m:mrpl52|MRPL52]]|0.416|
|[[:human genes:p:polrmt|POLRMT]]|0.414|
|[[:human genes:a:atp5d|ATP5D]]|0.413|
|[[:human genes:p:pet112|PET112]]|0.407|
|[[:human genes:p:polg2|POLG2]]|0.406|
|[[:human genes:n:ndufaf3|NDUFAF3]]|0.405|
|[[:human genes:n:ndufs7|NDUFS7]]|0.405|
|[[:human genes:a:aifm1|AIFM1]]|0.403|
|[[:human genes:m:mrpl38|MRPL38]]|0.402|
|[[:human genes:w:wars2|WARS2]]|0.401|
|[[:human genes:n:ndufb5|NDUFB5]]|0.401|
|[[:human genes:m:mrpl43|MRPL43]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 369/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|1/1|
|bile duct|14/28|
|blood|12/28|
|bone|10/26|
|breast|20/33|
|central nervous system|23/56|
|cervix|3/4|
|colorectal|7/17|
|esophagus|9/13|
|fibroblast|0/1|
|gastric|10/16|
|kidney|8/21|
|liver|8/20|
|lung|43/75|
|lymphocyte|6/16|
|ovary|9/26|
|pancreas|11/24|
|peripheral nervous system|5/16|
|plasma cell|6/15|
|prostate|1/1|
|skin|12/24|
|soft tissue|3/9|
|thyroid|0/2|
|upper aerodigestive|20/22|
|urinary tract|17/29|
|uterus|2/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 743
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.26 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MTPAP Expression in NALM6 Cells: 6.26'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>