MTRF1 [The Human Chemical-Genetic Interaction Map Project]

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======= MTRF1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MTRF1
  * **<color #00a2e8>Official Name</color>**: mitochondrial translation release factor 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9617|9617]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O75570|O75570]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MTRF1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MTRF1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604601|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Mitochondrial peptide chain release factor that directs the termination of translation in response to the peptide chain non-cognate termination stop codons AGG and AGA.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|RF-1|
|PCRF|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|translation release factor activity, codon specific|
|translation release factor activity|
|regulation of translational termination|
|ribosome binding|
|mitochondrial translational termination|
|translational termination|
|mitochondrial translation|
|regulation of protein complex disassembly|
|cellular protein complex disassembly|
|mitochondrial gene expression|
|protein-containing complex disassembly|
|regulation of translation|
|translation|
|cellular component disassembly|
|regulation of cellular amide metabolic process|
|peptide biosynthetic process|
|posttranscriptional regulation of gene expression|
|amide biosynthetic process|
|peptide metabolic process|
|cellular amide metabolic process|
|mitochondrion|
|organonitrogen compound biosynthetic process|
|cellular nitrogen compound biosynthetic process|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|protein-containing complex subunit organization|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp29|Rapamycin 1μM R00 exp29]]|1.7|
|[[:results:exp460|BML-284 0.09μM R08 exp460]]|1.86|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|2.08|
|[[:results:exp452|Azithromycin 100μM R08 exp452]]|2.33|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:g:gtpbp10|GTPBP10]]|0.479|
|[[:human genes:n:nars2|NARS2]]|0.477|
|[[:human genes:l:lars2|LARS2]]|0.454|
|[[:human genes:n:ndufaf7|NDUFAF7]]|0.446|
|[[:human genes:p:pet117|PET117]]|0.443|
|[[:human genes:m:mettl17|METTL17]]|0.44|
|[[:human genes:s:selrc1|SELRC1]]|0.439|
|[[:human genes:g:gfm2|GFM2]]|0.433|
|[[:human genes:m:mrpl21|MRPL21]]|0.427|
|[[:human genes:m:mrps5|MRPS5]]|0.423|
|[[:human genes:r:rpusd3|RPUSD3]]|0.419|
|[[:human genes:c:cars2|CARS2]]|0.417|
|[[:human genes:p:pnpt1|PNPT1]]|0.412|
|[[:human genes:y:yars2|YARS2]]|0.412|
|[[:human genes:m:mtrf1l|MTRF1L]]|0.412|
|[[:human genes:n:ndufa3|NDUFA3]]|0.411|
|[[:human genes:n:ndufaf4|NDUFAF4]]|0.411|
|[[:human genes:f:ftsj2|FTSJ2]]|0.41|
|[[:human genes:c:c12orf65|C12orf65]]|0.41|
|[[:human genes:q:qrsl1|QRSL1]]|0.407|
|[[:human genes:m:mrps14|MRPS14]]|0.404|
|[[:human genes:c:clpp|CLPP]]|0.403|
|[[:human genes:n:ndufs2|NDUFS2]]|0.402|
|[[:human genes:g:grsf1|GRSF1]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2607
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.09 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MTRF1 Expression in NALM6 Cells: 5.09'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>