MTRNR2L5 [The Human Chemical-Genetic Interaction Map Project]

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======= MTRNR2L5 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MTRNR2L5
  * **<color #00a2e8>Official Name</color>**: MT-RNR2 like 5
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=100463289|100463289]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P0CJ72|P0CJ72]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MTRNR2L5&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MTRNR2L5|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**:  N/A

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Plays a role as a neuroprotective and antiapoptotic factor. {ECO:0000250|UniProtKB:Q8IVG9, ECO:0000269|PubMed:19477263}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of mitochondrial membrane permeability involved in apoptotic process|
|cellular response to staurosporine|
|response to staurosporine|
|negative regulation of mitochondrial membrane permeability|
|negative regulation of membrane permeability|
|regulation of mitochondrial membrane permeability involved in apoptotic process|
|negative regulation of execution phase of apoptosis|
|receptor antagonist activity|
|cellular response to alkaloid|
|regulation of execution phase of apoptosis|
|negative regulation of signaling receptor activity|
|apoptotic mitochondrial changes|
|regulation of mitochondrial membrane permeability|
|regulation of membrane permeability|
|response to alkaloid|
|mitochondrial membrane organization|
|cellular response to ammonium ion|
|regulation of signaling receptor activity|
|response to ammonium ion|
|mitochondrial transport|
|mitochondrion organization|
|cellular component|
|cellular response to organic cyclic compound|
|cellular response to organonitrogen compound|
|cellular response to nitrogen compound|
|molecular function|
|membrane organization|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|response to organic cyclic compound|
|apoptotic process|
|negative regulation of cell death|
|response to organonitrogen compound|
|programmed cell death|
|response to nitrogen compound|
|cell death|
|negative regulation of molecular function|
|cellular response to endogenous stimulus|
|mitochondrion|
|response to endogenous stimulus|
|regulation of apoptotic process|
|regulation of programmed cell death|
|regulation of cell death|
|extracellular region|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp240|Pyridostatin 4μM R05 exp240]]|-1.84|
|[[:results:exp189|Temozolomide 200μM R04 exp189]]|-1.71|
|[[:results:exp303|39°C R06 exp303]]|1.71|
|[[:results:exp37|Wortmannin 0.5μM R00 exp37]]|1.8|
|[[:results:exp71|KU-0063794 3.8μM R02 exp71]]|1.83|
|[[:results:exp417|Tubastatin-A 2.5μM R07 exp417]]|2.18|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15209
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.61 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MTRNR2L5 Expression in NALM6 Cells: 4.61'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>