MTRR [The Human Chemical-Genetic Interaction Map Project]

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======= MTRR =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MTRR
  * **<color #00a2e8>Official Name</color>**: 5-methyltetrahydrofolate-homocysteine methyltransferase reductase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4552|4552]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9UBK8|Q9UBK8]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MTRR&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MTRR|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602568|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the ferredoxin-NADP(+) reductase (FNR) family of electron transferases. This protein functions in the synthesis of methionine by regenerating methionine synthase to a functional state. Because methionine synthesis requires methyl-group transfer by a folate donor, activity of the encoded enzyme is important for folate metabolism and cellular methylation. Mutations in this gene can cause homocystinuria-megaloblastic anemia, cbl E type. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Dec 2015]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Involved in the reductive regeneration of cob(I)alamin (vitamin B12) cofactor required for the maintenance of methionine synthase in a functional state. Necessary for utilization of methylgroups from the folate cycle, thereby affecting transgenerational epigenetic inheritance. Folate pathway donates methyl groups necessary for cellular methylation and affects different pathways such as DNA methylation, possibly explaining the transgenerational epigenetic inheritance effects. {ECO:0000269|PubMed:17892308}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|FAD binding 1|
|NAD binding 1|
|Flavodoxin 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|[methionine synthase] reductase activity|
|negative regulation of cystathionine beta-synthase activity|
|regulation of cystathionine beta-synthase activity|
|oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor|
|aquacobalamin reductase (NADPH) activity|
|homocysteine catabolic process|
|NADPH-hemoprotein reductase activity|
|S-adenosylmethionine cycle|
|homocysteine metabolic process|
|methionine biosynthetic process|
|NADPH binding|
|sulfur amino acid catabolic process|
|FMN binding|
|methionine metabolic process|
|sulfur amino acid biosynthetic process|
|S-adenosylmethionine metabolic process|
|folic acid metabolic process|
|cobalamin metabolic process|
|negative regulation of lyase activity|
|aspartate family amino acid biosynthetic process|
|folic acid-containing compound metabolic process|
|FAD binding|
|pteridine-containing compound metabolic process|
|NADP binding|
|sulfur amino acid metabolic process|
|regulation of lyase activity|
|DNA alkylation|
|DNA methylation|
|aspartate family amino acid metabolic process|
|sulfur compound catabolic process|
|flavin adenine dinucleotide binding|
|tetrapyrrole metabolic process|
|alpha-amino acid biosynthetic process|
|DNA methylation or demethylation|
|cellular amino acid biosynthetic process|
|water-soluble vitamin metabolic process|
|DNA modification|
|dicarboxylic acid metabolic process|
|alpha-amino acid catabolic process|
|oxidoreductase activity|
|vitamin metabolic process|
|cellular amino acid catabolic process|
|sulfur compound biosynthetic process|
|cellular modified amino acid metabolic process|
|alpha-amino acid metabolic process|
|coenzyme metabolic process|
|macromolecule methylation|
|carboxylic acid catabolic process|
|organic acid catabolic process|
|carboxylic acid biosynthetic process|
|organic acid biosynthetic process|
|cellular amino acid metabolic process|
|methylation|
|sulfur compound metabolic process|
|small molecule catabolic process|
|cofactor metabolic process|
|drug metabolic process|
|small molecule biosynthetic process|
|DNA metabolic process|
|cellular amide metabolic process|
|negative regulation of catalytic activity|
|carboxylic acid metabolic process|
|oxidation-reduction process|
|oxoacid metabolic process|
|organic acid metabolic process|
|organonitrogen compound catabolic process|
|negative regulation of molecular function|
|organonitrogen compound biosynthetic process|
|small molecule metabolic process|
|organic substance catabolic process|
|cellular catabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp501|Methotrexate 0.01μM R08 exp501]]|-2.49|
|[[:results:exp432|YM155 0.001μM R08 exp432]]|-1.78|
|[[:results:exp380|NMS-873 0.07μM R07 exp380]]|1.8|
|[[:results:exp274|Citral 50μM R06 exp274]]|1.87|
|[[:results:exp13|Chloramphenicol 20μM R00 exp13]]|2.22|
|[[:results:exp183|IU1-C 25μM R04 exp183]]|2.25|
|[[:results:exp211|AICAR 240μM R05 exp211]]|4.37|
|[[:results:exp116|AICAR 240μM R03 exp116]]|5.85|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:m:mtr|MTR]]|0.622|
|[[:human genes:m:mthfd2|MTHFD2]]|0.579|
|[[:human genes:m:mthfd1l|MTHFD1L]]|0.55|
|[[:human genes:s:slc25a32|SLC25A32]]|0.531|
|[[:human genes:m:mmachc|MMACHC]]|0.464|
|[[:human genes:s:shmt2|SHMT2]]|0.417|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5869
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.92 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MTRR Expression in NALM6 Cells: 5.92'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>