MTSS1L [The Human Chemical-Genetic Interaction Map Project]

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======= MTSS1L =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MTSS2
  * **<color #00a2e8>Official Name</color>**: MTSS I-BAR domain containing 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=92154|92154]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q765P7|Q765P7]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MTSS1L&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MTSS1L|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/616951|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Involved in plasma membrane dynamics. Potentiated PDGF- mediated formation of membrane ruffles and lamellipodia in fibroblasts, acting via RAC1 activation (PubMed:14752106). May function in actin bundling (PubMed:14752106). {ECO:0000269|PubMed:14752106}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|IMD|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|ruffle assembly|
|cellular response to platelet-derived growth factor stimulus|
|response to platelet-derived growth factor|
|ruffle organization|
|actin monomer binding|
|lamellipodium organization|
|cortical actin cytoskeleton|
|Rac GTPase binding|
|phosphatidylinositol-4,5-bisphosphate binding|
|plasma membrane organization|
|ruffle membrane|
|activation of GTPase activity|
|lamellipodium|
|GTPase activator activity|
|positive regulation of GTPase activity|
|endomembrane system organization|
|plasma membrane bounded cell projection assembly|
|cell projection assembly|
|regulation of GTPase activity|
|cellular response to growth factor stimulus|
|response to growth factor|
|positive regulation of hydrolase activity|
|membrane organization|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|cellular response to endogenous stimulus|
|regulation of hydrolase activity|
|positive regulation of catalytic activity|
|response to endogenous stimulus|
|positive regulation of molecular function|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp60|Vinblastine 0.002μM R01 exp60]]|-2.48|
|[[:results:exp165|RO-3306 3 to 4μM on day4 R04 exp165]]|-2.34|
|[[:results:exp228|Demecolcine 0.03μM R05 exp228]]|-1.73|
|[[:results:exp123|GSK-LSD1 10μM R03 exp123]]|-1.7|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6118
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.75 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MTSS1L Expression in NALM6 Cells: 3.75'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>