MUC5AC [The Human Chemical-Genetic Interaction Map Project]

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======= MUC5AC =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MUC5AC
  * **<color #00a2e8>Official Name</color>**: mucin 5AC, oligomeric mucus/gel-forming
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4586|4586]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P98088|P98088]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MUC5AC&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MUC5AC|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/158373|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Gel-forming glycoprotein of gastric and respiratoy tract epithelia that protects the mucosa from infection and chemical damage by binding to inhaled microrganisms and particles that are subsequently removed by the mucocilary system.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|VWC|
|C8|
|VWD|
|TIL|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|mucus layer|
|O-glycan processing|
|phosphatidylinositol-mediated signaling|
|inositol lipid-mediated signaling|
|Golgi lumen|
|protein O-linked glycosylation|
|stimulatory C-type lectin receptor signaling pathway|
|innate immune response activating cell surface receptor signaling pathway|
|extracellular matrix structural constituent|
|innate immune response-activating signal transduction|
|activation of innate immune response|
|protein glycosylation|
|macromolecule glycosylation|
|glycosylation|
|glycoprotein biosynthetic process|
|positive regulation of innate immune response|
|positive regulation of response to biotic stimulus|
|glycoprotein metabolic process|
|immune response-activating cell surface receptor signaling pathway|
|regulation of innate immune response|
|positive regulation of defense response|
|immune response-regulating cell surface receptor signaling pathway|
|positive regulation of multi-organism process|
|regulation of response to biotic stimulus|
|immune response-activating signal transduction|
|immune response-regulating signaling pathway|
|positive regulation of response to external stimulus|
|carbohydrate derivative biosynthetic process|
|activation of immune response|
|regulation of defense response|
|regulation of multi-organism process|
|positive regulation of immune response|
|carbohydrate derivative metabolic process|
|regulation of response to external stimulus|
|regulation of immune response|
|positive regulation of immune system process|
|organonitrogen compound biosynthetic process|
|regulation of response to stress|
|extracellular space|
|regulation of immune system process|
|intracellular signal transduction|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: N/A
^Tissue^Fraction Of Cell Lines Where Essential^
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6616
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -7.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MUC5AC Expression in NALM6 Cells: -7.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>