MYH13 [The Human Chemical-Genetic Interaction Map Project]

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======= MYH13 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MYH13
  * **<color #00a2e8>Official Name</color>**: myosin heavy chain 13
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8735|8735]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9UKX3|Q9UKX3]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MYH13&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MYH13|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603487|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Fast twitching myosin mediating the high-velocity and low-tension contractions of specific striated muscles. {ECO:0000269|PubMed:23908353}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Myosin N|
|Myosin head|
|Myosin tail 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|muscle myosin complex|
|myosin filament|
|microfilament motor activity|
|myofibril|
|cellular response to starvation|
|response to starvation|
|calmodulin binding|
|actin filament binding|
|cellular response to nutrient levels|
|muscle contraction|
|cellular response to extracellular stimulus|
|muscle system process|
|cellular response to external stimulus|
|response to nutrient levels|
|response to extracellular stimulus|
|ATP binding|
|cellular response to stress|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp189|Temozolomide 200μM R04 exp189]]|-2.24|
|[[:results:exp145|PNU96415E 10μM R03 exp145]]|-2.05|
|[[:results:exp69|Deguelin 0.05μM R02 exp69]]|-2.02|
|[[:results:exp210|LB-100 2μM R05 exp210]]|-1.99|
|[[:results:exp528|TGF-beta1 44ng/ml R08 exp528]]|-1.96|
|[[:results:exp177|Apcin 25μM plus proTAME 2μM R04 exp177]]|-1.9|
|[[:results:exp241|QNZ 0.01μM R05 exp241]]|-1.85|
|[[:results:exp90|WYE-354 6μM R02 exp90]]|-1.83|
|[[:results:exp524|Staurosporine 0.02μM R08 exp524]]|-1.82|
|[[:results:exp538|ZLN024 50μM R08 exp538]]|-1.75|
|[[:results:exp270|Campthothecin 0.001μM R06 exp270]]|-1.73|
|[[:results:exp414|Tozasertib 0.1μM R07 exp414]]|-1.73|
|[[:results:exp215|Colchicine 0.009μM R05 exp215]]|-1.72|
|[[:results:exp18|Doxycycline 10μM R00 exp18]]|1.76|
|[[:results:exp492|iCRT14 30μM R08 exp492]]|1.87|
|[[:results:exp494|Isoniazid 100μM R08 exp494]]|1.93|
|[[:results:exp187|proTAME 5μM R04 exp187]]|2.36|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 9669
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -6.6 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MYH13 Expression in NALM6 Cells: -6.6'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>